Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11205 |
ent-Ezetimibe
ent-SCH 58235,ENT-依折麦布 |
Others | Others |
ent-Ezetimibe (ent-SCH 58235) 是 Ezetimibe 的 RRS 型对映体。其中Ezetimibe 是一种胆固醇吸收 (cholesterol-absorption) 抑制剂,是NPC1L1抑制剂,也是有效的Nrf2激活剂。 | |||
T1593 |
Ezetimibe
依泽替米贝,SCH 58235 |
Others; Nrf2; NPC1L1; Autophagy | Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Others |
Ezetimibe (SCH 58235) 是一种膳食胆固醇吸收抑制剂。它是一种NPC1L1抑制剂,是有效的Nrf2激活剂。 | |||
T11250 |
Ezetimibe-d4
SCH 58235 D4 |
Others | Others |
Ezetimibe D4, a deuterium-labeled variant of Ezetimibe, functions as an inhibitor of Niemann-Pick C1-like1 (NPC1L1) and is recognized for its potent activation of Nrf2. | |||
T70849 | AZD-4121 | ||
AZD-4121 is an oral cholesterol absorption inhibitor targeting NPC1L1 for the treatment of dyslipidaemia. | |||
T70848 |
AZD-4121 tert-butylammonium
|
||
AZD-4121 tert-butylammonium is an oral cholesterol absorption inhibitor targeting NPC1L1 for the treatment of dyslipidaemia. | |||
T11003 |
Desfluoro-ezetimibe
|
Others | Others |
Desfluoro-ezetimibe is the defluorinated impurity of ezetimibe. Ezetimibe is an effective, metabolically stable cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor and an effective Nrf2 activator. | |||
T11251 |
Ezetimibe ketone
EZM-K |
Nrf2; NPC1L1 | Immunology/Inflammation; Membrane transporter/Ion channel |
Ezetimibe, a compound known as a Niemann-Pick C1-like1 (NPC1L1) inhibitor and a potent Nrf2 activator, effectively inhibits cholesterol absorption. Additionally, Ezetimibe ketone (EZM-K) represents a phase-I metabolite of Ezetimibe. | |||
T16322 |
Nicodicosapent
|
Others | Others |
Nicodicosapent is a fatty acid niacin conjugate. It is also an inhibitor of the sterol regulatory element-binding protein (SREBP). The sterol regulatory element-binding protein (SREBP) is a key regulator of cholesterol metabolism proteins such as PCSK9, H |