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9

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T73447	NP10679
	NP10679 是一种选择性、pH 依赖性的GluN2B 亚基特异的 N-methyl-D-aspartate (NMDA) 受体抑制剂，具有较高的口服生物利用度和良好的脑穿透性。NP10679 在 pH 6.9 和 7.6 下，抑制 GluN2B 的IC50分别为 23 和 142 nM。NP10679 是histamine H1的拮抗剂和hERG 通道抑制剂，IC50分别为 73 和 620 nM。NP10679 是一种可逆的人肝脏CYP 酶抑制剂。
T7334	NP118809 39-1B4,1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	NP118809 (39-1B4) 是 N 型钙通道阻滞剂，IC50值为 0.11 μM。它较弱地抑制 L 型钙通道，IC50值为 12.2 μM。
T40067	SENP1-IN-4 SENP1-IN-4
	SENP1-IN-4, a distinct inhibitor of the deSUMOylation protease 1 (SENP1), is designed to enhance tumor radiosensitivity.
T40066	SENP1-IN-3 SENP1-IN-3
	SENP1-IN-3 is a distinct inhibitor of the deSUMOylation protease 1 (SENP1), designed to enhance tumor radiosensitivity.
T73191	LONP1-IN-2
	LONP1-IN-2 是一种有效的选择性 LONP1抑制剂，对 LONP1 和 20S 蛋白酶体的IC50值分别为 0.187 μM 和 >10 μM。LONP1-IN-2可用于癌症研究。
T40068	SENP1-IN-1 SENP1-IN-1
	SENP1-IN-1 is a distinct inhibitor of the deSUMOylation protease 1 (SENP1), designed to enhance tumor radiosensitivity.
T40069	SENP1-IN-2 SENP1-IN-2
	SENP1-IN-2, a distinct inhibitor of the deSUMOylation protease 1 (SENP1), is designed to enhance tumor radiosensitivity.
T36900	PD-1/PD-L1-IN-NP19 PD-1/PD-L1-IN-NP19	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-NP19 是 PD-1/PD-L1 的抑制剂，抑制人类 PD-1/PD-L1 相互作用的 IC50 值为 12.5 nM。PD-1/PD-L1-IN-NP19 可以激活肿瘤的免疫微环境，这可能有助于其抗肿瘤作用。
T83851	Tat-QFNP12 TFA
	Tat-QFNP12 是一种含有转录激活因子 (Tat) 跨膜结构域和抑制N-Myc下游调节基因2 (NDRG2) 与蛋白磷酸酶Mg2+/Mn2+依赖性1A (PPM1A) 蛋白-蛋白相互作用的肽。在以20 mg/kg剂量给药的内脑血管穿刺诱导的小鼠蛛网膜下腔出血模型中，它能减少由基质金属蛋白酶-9 (MMP-9) 浓度增高引起的血脑屏障内皮紧密连接的损失，减轻脑水肿，并且提高自发活动及肢体运动的对称性。

化合物

Cat.No: T73447

Cat.No: T7334

Synonym: 39-1B4,1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮

Target: Calcium Channel

Cat.No: T40067

Synonym: SENP1-IN-4

Cat.No: T40066

Synonym: SENP1-IN-3

Cat.No: T73191

Cat.No: T40068

Synonym: SENP1-IN-1

Cat.No: T40069

Synonym: SENP1-IN-2

PD-1/PD-L1-IN-NP19

Cat.No: T36900

Synonym: PD-1/PD-L1-IN-NP19

Target: PD-1/PD-L1

Cat.No: T83851

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02367	Neuropilin-1 Protein, Human, Recombinant (isoform b, His) neuropilin 1,NRP,VEGF165R,BDCA4,Neuropilin...	Human	HEK293 Cells
	Neuropilin-1 Protein, Human, Recombinant (isoform b, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.3 kDa and the accession number is O14786-2.
TMPY-00891	Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) neuropilin 1,VEGF165R,CD304,NP	Human	HEK293 Cells
	Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.5 kDa and the accession number is O14786-2.
TMPJ-01130	NPTX1 Protein, Human, Recombinant (His) Neuronal pentraxin-1,NPTX1,NP...	Human	HEK293 Cells
	Neuronal Pentraxin (NPTX1, NP1) is a secreted glycoprotein within the Pentraxin family. NPTX1 is co‑expressed and forms heteromultimers with the related secreted protein, NPTX2/NARP, NPTXR (Neuronal Pentraxin Receptor) at excitatory synapses. Mature human NPTX1 shares 97% aa sequence identity with mouse, and rat NPTX1. It is produced by hippocampal, cerebral and cerebellar neurons, retinal ganglia and the inner nuclear layer of the retina. It is enriched on presynaptic axonal membranes where it ...
TMPY-05585	Neuropilin-1 Protein, Human, Recombinant (Avi & His), Biotinylated CD304,BDCA4,neuropilin 1,NRP,Neuropilin-1,...	Human	HEK293 Cells
	Neuropilin-1 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 73.1 kDa and the accession number is O14786-2.
TMPY-06370	Neuropilin-1 Protein, Human, Recombinant (His) BDCA4,NRP,neuropilin 1,Neuropilin-1,VEGF	Human	HEK293 Cells
	Neuropilin-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.33 kDa and the accession number is NP_001019799.2.
TMPY-06477	Neuropilin-1 Protein, Human, Recombinant (aa 1-64, N150Q, His) NRP,neuropilin 1,CD304,VEGF165R,Neuropilin...	Human	HEK293 Cells
	Neuropilin-1 Protein, Human, Recombinant (aa 1-64, N150Q, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.31 kDa and the accession number is NP_001019799.2.
TMPY-05740	Neuropilin-1 Protein, Mouse, Recombinant (His) neuropilin 1,Npn1,Nrp,NP...	Mouse	HEK293 Cells
	Neuropilin-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 95.12 kDa and the accession number is P97333.
TMPY-05519	Neuropilin-1 Protein, Mouse, Recombinant (mFc) NPN-1,neuropilin 1,Nrp,C530029I03...	Mouse	HEK293 Cells
	Neuropilin-1 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 120 kDa and the accession number is P97333.

重组蛋白

Neuropilin-1 Protein, Human, Recombinant (isoform b, His)

Cat.No: TMPY-02367

Species: Human

Expression System: HEK293 Cells

Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)

Cat.No: TMPY-00891

Species: Human

Expression System: HEK293 Cells

NPTX1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01130

Species: Human

Expression System: HEK293 Cells

Neuropilin-1 Protein, Human, Recombinant (Avi & His), Biotinylated

Cat.No: TMPY-05585

Species: Human

Expression System: HEK293 Cells

Neuropilin-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-06370

Species: Human

Expression System: HEK293 Cells

Neuropilin-1 Protein, Human, Recombinant (aa 1-64, N150Q, His)

Cat.No: TMPY-06477

Species: Human

Expression System: HEK293 Cells

Neuropilin-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-05740

Species: Mouse

Expression System: HEK293 Cells

Neuropilin-1 Protein, Mouse, Recombinant (mFc)

Cat.No: TMPY-05519

Species: Mouse

Expression System: HEK293 Cells

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