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Cat. No.	Product Name	Target	Signaling Pathways
T60306	NMDA receptor antagonist 4
	NMDA receptor antagonist 4 (IIc) 是一个非竞争性、电压依赖的、口服活性的 NMDAR 阻断剂，IC50值为1.93 μM。NMDA receptor antagonist 4 可透过血脑屏障，可用于研究阿兹海默症。
T22674	Co 101244 hydrochloride Co 101244盐酸盐,4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride	NMDAR	Neuroscience
	Co 101244 hydrochloride (4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride) 是一种含有 NR2B 的 NMDA 受体拮抗剂。
T26686	AV-101 L-4-Cl-KYN,L-4-chlorokynurenine,4-Cl-KYN,4ClKYN,4-Chlorokynurenine,(S)-4-Chlorokynurenine	NMDAR	Neuroscience
	AV-101 (4-Cl-KYN) 是 NMDA 受体甘氨酸位点的前药拮抗剂，具有抗抑郁活性，可减少 MPTP 猴子中左旋多巴诱导的运动障碍。
T22513	4-PPBP maleate	Sigma receptor; NMDAR	GPCR/G Protein; Neuroscience
	4-PPBP maleate 是一种有效的 σ1 受体（配体）激动剂。4-PPBP maleate 在Xenopus oocytes 表达的情况下可被认为是一种具有选择性、非竞争性的 NR1a/2B NMDA 受体拮抗剂。4-PPBP maleate 具有神经保护特性。
T60330	Metapramine
	Metapramine (19560 RP) 是一种三环类抗抑郁剂。Metapramine 抑制去甲肾上腺素 (norepinephrine) 的再摄取，而不影响血清素或多巴胺的再摄取。Metapramine 是 N-methyl-D-aspartic acid (NMDA) 受体复合物通道的低亲和力拮抗剂。
T23217	(R)-4-Carboxyphenylglycine	Others	Others
	(R)-4-Carboxyphenylglycine is a NMDA receptor antagonist.
T23036	N-(4-Hydroxyphenylacetyl)spermine	Others	Others
	N-(4-Hydroxyphenylacetyl)spermine is a NMDA receptor antagonist.
T19863	AP-4 AP4
	AP-4 is an antagonist of the NMDA glutamate receptor.
T71760	4-Chlorokynurenine
	4-Chlorokynurenine is a prodrug of 7-Cl-kynurenic acid (7-Cl-KYNA), a potent, selective antagonist of the NMDA/glycine receptor.
T70063	GYKI 52466 HCl
	GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 µM).2 GYKI 52466 (10 µM) reduces the amplitude of spontaneous excitatory postsynaptic currents (EPSCs) in the same cells. It increases the latency to seizure onset and reduces mortality in a rat model of general...

化合物

NMDA receptor antagonist 4

Cat.No: T60306

Synonym:

Target:

Co 101244 hydrochloride

Cat.No: T22674

Synonym: Co 101244盐酸盐,4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride

Target: NMDAR

AV-101

Cat.No: T26686

Synonym: L-4-Cl-KYN,L-4-chlorokynurenine,4-Cl-KYN,4ClKYN,4-Chlorokynurenine,(S)-4-Chlorokynurenine

Target: Sigma receptor, NMDAR

(R)-4-Carboxyphenylglycine

Cat.No: T23217

Synonym:

Target: Others

N-(4-Hydroxyphenylacetyl)spermine

Cat. No.	Product Name	Target	Signaling Pathways
T10191L	7-Chlorokynurenic acid 7-chloro-4-hydroxy-2-carboxyquinoline,7-氯犬尿酸,7-CKA	GluR; NMDAR	Neuroscience
	7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) 是一种有效的选择性 NMDA 受体拮抗剂，对甘氨酸 B 激动剂位点的 IC50 为 0.56 μM。 7-Chlorokynurenic acid 抑制谷氨酸再摄取到突触小泡中，Ki 为 0.59 μM，并在神经轴输送后显示出镇痛作用。

天然产物

7-Chlorokynurenic acid

Cat.No: T10191L

Synonym: 7-chloro-4-hydroxy-2-carboxyquinoline,7-氯犬尿酸,7-CKA

Target: GluR, NMDAR

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