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Cat. No.	Product Name	Target	Signaling Pathways
T36880	NHC-diphosphate
	NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a diphosphate form[1]. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV)[1]. Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC.Intracellular levels of the parental compounds and ...
T36881	NHC-diphosphate triammonium
	NHC-triphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form[1]. NHC-triphosphate triammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2]. In an intracellular metabolism assay, HCV replicon cells are treated with 10 μM 3H-labeled NHC, and intracellular nucleotide levels are determined after 1, 2 and 8 hours incubations. NHC is rapidly convered into the mono...
T19476	NHC-triphosphate	Others	Others
	NHC-triphosphate is a weak alternative substrate for the viral polymerase and changes the mobility of the product in polyacrylamide electrophoresis gels.
T74070	NHC-triphosphate tetrasodium
	NHC-triphosphate tetrasodium 是 NHC 的活性胞内磷酸盐代谢物 (intracellular metabolite)，以三磷酸盐的形式存在。NHC-triphosphate tetrasodium 是病毒聚合酶 (viral polymerase) 的弱底物替代物，会被并入HCV 复制子 RNA 中。
T8498	EIDD-1931 Beta-d-N4-hydroxycytidine	Virus Protease; HCV Protease; SARS-CoV; Topoisomerase	DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	EIDD-1931 (Beta-d-N4-hydroxycytidine) 是一种核苷类抗病毒试剂，可抑制丙型肝炎病毒、基孔肯亚病毒和委内瑞拉马脑炎病毒的复制活性。
T18794	Tetrazine-Ph-NHCO-C3-NHS ester	Others; PROTAC Linker	Others; PROTAC
	Tetrazine-Ph-NHCO-C3-NHS ester是一种源于PEG的PROTACs合成连接剂。
T17763	DBCO-NHCO-PEG2-amine	Others	Others
	DBCO-NHCO-PEG2-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17768	DBCO-NHCO-PEG3-acid	Others	Others
	DBCO-NHCO-PEG3-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15061	DBCO-NHCO-PEG4-acid	Others	Others
	DBCO-Amide-PEG5-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T18795	Tetrazine-Ph-NHCO-PEG3-alcohol	Others	Others
	Tetrazine-Ph-NHCO-PEG3-alcohol is a polyethylene glycol (PEG) derived linker specifically designed for use in the synthesis of proteolysis targeting chimeras (PROTACs)[1].
T39186	Boc-NHCH2CH2-PEG1-azide Boc-NHCH2CH2-PEG1-azide
	Boc-NHCH2CH2-PEG1-azide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17761	DBCO-NHCO-PEG13-acid	Others	Others
	DBCO-NHCO-PEG13-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17773	DBCO-NHCO-PEG7-acid	Others	Others
	DBCO-NHCO-PEG7-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17759	DBCO-NHCO-PEG12-biotin	Others	Others
	DBCO-NHCO-PEG12-biotin is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T15064	DBCO-NHCO-PEG4-NHS ester	Others	Others
	DBCO-NHCO-PEG4-NHS ester ester is a MMP-2- and cathepsin B- (CatB) cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T18798	Tetrazine-Ph-NHCO-PEG6-NH-Boc	Others	Others
	Tetrazine-Ph-NHCO-PEG6-NH-Boc is a PEG-based PROTAC linker utilized for PROTACs synthesis[1].
T17774	DBCO-NHCO-S-S-NHS ester	Others	Others
	DBCO-NHCO-S-S-NHS ester is a cleavable linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].
T17757	DBCO-NHCO-C4-NHS ester	Others	Others
	DBCO-NHCO-C4-NHS ester is an alkyl chain-derived PROTAC linker applicable for PROTACs synthesis[1].
T17758	DBCO-NHCO-PEG12-amine	Others	Others
	DBCO-NHCO-PEG12-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17770	DBCO-NHCO-PEG6-amine	Others	Others
	DBCO-NHCO-PEG6-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18796	Tetrazine-Ph-NHCO-PEG4-alkyne	Others	Others
	Tetrazine-Ph-NHCO-PEG4-alkyne is a PEG4-based linker for PROTACs synthesis[1].
T40049	MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin
	MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (compound 21a), is a camptothecin payload which can be utilized in the synthesis of a camptothecin antibody-drug conjugate (ADC) by conjugation to a monoclonal antibody (mAb).
T15062	DBCO-NHCO-PEG4-amine	Others	Others
	DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively)[1].
T17771	DBCO-NHCO-PEG6-Biotin	Others	Others
	DBCO-NHCO-PEG6-Biotin is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17760	DBCO-NHCO-PEG12-maleimide	Others	Others
	DBCO-NHCO-PEG12-maleimide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs[1].
T17767	DBCO-NHCO-PEG2-NHS ester	Others	Others
	DBCO-NHCO-PEG2-NHS ester, a PEG-based PROTAC linker, enables the synthesis of PROTACs[1].
T17766	DBCO-NHCO-PEG2-maleimide	Others	Others
	DBCO-NHCO-PEG2-maleimide is a polyethylene glycol (PEG) derived PROTAC linker utilized during PROTAC synthesis[1].
T15065	DBCO-NHCO-PEG5-NHS ester	Others	Others
	DBCO-NHCO-PEG5-NHS ester is a polyethylene glycol (PEG)-based linker utilized in the synthesis of PROTACs[1].
T17772	DBCO-NHCO-PEG6-maleimide	Others	Others
	DBCO-NHCO-PEG6-maleimide is a polyethylene glycol (PEG)-based linker compound employed in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T17764	DBCO-NHCO-PEG2-Biotin	Others	Others
	DBCO-NHCO-PEG2-Biotin is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17765	DBCO-NHCO-PEG2-CH2COOH	Others	Others
	DBCO-NHCO-PEG2-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T17769	DBCO-NHCO-PEG3-Fmoc	Others	Others
	DBCO-NHCO-PEG3-Fmoc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
T18797	Tetrazine-Ph-NHCO-PEG4-NH-Boc	Others	Others
	Tetrazine-Ph-NHCO-PEG4-NH-Boc is a PEGylated PROTAC linker suitable for PROTAC synthesis[1].
T17762	DBCO-NHCO-PEG13-NHS ester	Others	Others
	DBCO-NHCO-PEG13-NHS ester is a pegylated PROteolysis-TArgeting Chimera (PROTAC) linker, serving as a valuable tool for PROTAC synthesis[1].
T15063	DBCO-NHCO-PEG4-NH-Boc	Others	Others
	DBCO-NHCO-PEG4-NH-Boc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T40048	MC-AAA-NHCH2OCH2COOH MC-AAA-NHCH2OCH2COOH
	MC-AAA-NHCH2OCH2COOH (compound 20) is a cleavable antibody-drug conjugate (ADC) linker. Its primary application lies in the synthesis of ADCs.
T82934	AuM1Phe	Topoisomerase	DNA Damage/DNA Repair
	AuM1Phe是一种N-杂环卡宾(NHC)金属络合物，其作用机制包括抑制人类拓扑异构酶I活性和阻碍肌动蛋白聚合。在MDA-MB-231乳腺癌细胞上，AuM1Phe展现了抑制细胞生长的效果，具有1.2 μM的IC50值。
T74225	ROS-ERS inducer 1
	ROS-ERS inducer 1 是一种基于4,5-二芳基咪唑的Pt(II)-N-杂环卡宾 (Pt(II)-NHC) 复合物，属于 II 型免疫原性细胞死亡(ICD)诱导剂。它能促使内质网应激(ERS)并伴随活性氧(ROS)的生成，进而在HCC细胞中触发损伤相关分子模式(DAMP)的释放。相比Cisplatin，ROS-ERS inducer 1 表现出更高的抗癌效能。

化合物

NHC-diphosphate

Cat.No: T36880

NHC-diphosphate triammonium

Cat.No: T36881

NHC-triphosphate

Cat.No: T19476

Target: Others

NHC-triphosphate tetrasodium

Cat.No: T74070

Cat.No: T8498

Synonym: Beta-d-N4-hydroxycytidine

Target: Virus Protease, HCV Protease, SARS-CoV, Topoisomerase

Tetrazine-Ph-NHCO-C3-NHS ester

Cat.No: T18794

Target: Others, PROTAC Linker

DBCO-NHCO-PEG2-amine

Cat.No: T17763

Target: Others

DBCO-NHCO-PEG3-acid

Cat.No: T17768

Target: Others

DBCO-NHCO-PEG4-acid

Cat.No: T15061

Target: Others

Tetrazine-Ph-NHCO-PEG3-alcohol

Cat.No: T18795

Target: Others

Boc-NHCH2CH2-PEG1-azide

Cat.No: T39186

Synonym: Boc-NHCH2CH2-PEG1-azide

DBCO-NHCO-PEG13-acid

Cat.No: T17761

Target: Others

DBCO-NHCO-PEG7-acid

Cat.No: T17773

Target: Others

DBCO-NHCO-PEG12-biotin

Cat.No: T17759

Target: Others

DBCO-NHCO-PEG4-NHS ester

Cat.No: T15064

Target: Others

Tetrazine-Ph-NHCO-PEG6-NH-Boc

Cat.No: T18798

Target: Others

DBCO-NHCO-S-S-NHS ester

Cat.No: T17774

Target: Others

DBCO-NHCO-C4-NHS ester

Cat.No: T17757

Target: Others

DBCO-NHCO-PEG12-amine

Cat.No: T17758

Target: Others

DBCO-NHCO-PEG6-amine

Cat.No: T17770

Target: Others

Tetrazine-Ph-NHCO-PEG4-alkyne

Cat.No: T18796

Target: Others

MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin

Cat.No: T40049

Synonym: MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin

DBCO-NHCO-PEG4-amine

Cat.No: T15062

Target: Others

DBCO-NHCO-PEG6-Biotin

Cat.No: T17771

Target: Others

DBCO-NHCO-PEG12-maleimide

Cat.No: T17760

Target: Others

DBCO-NHCO-PEG2-NHS ester

Cat.No: T17767

Target: Others

DBCO-NHCO-PEG2-maleimide

Cat.No: T17766

Target: Others

DBCO-NHCO-PEG5-NHS ester

Cat.No: T15065

Target: Others

DBCO-NHCO-PEG6-maleimide

Cat.No: T17772

Target: Others

DBCO-NHCO-PEG2-Biotin

Cat.No: T17764

Target: Others

DBCO-NHCO-PEG2-CH2COOH

Cat.No: T17765

Target: Others

DBCO-NHCO-PEG3-Fmoc

Cat.No: T17769

Target: Others

Tetrazine-Ph-NHCO-PEG4-NH-Boc

Cat.No: T18797

Target: Others

DBCO-NHCO-PEG13-NHS ester

Cat.No: T17762

Target: Others

DBCO-NHCO-PEG4-NH-Boc

Cat.No: T15063

Target: Others

MC-AAA-NHCH2OCH2COOH

Cat.No: T40048

Synonym: MC-AAA-NHCH2OCH2COOH

Cat.No: T82934

Target: Topoisomerase

ROS-ERS inducer 1

Cat.No: T74225

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