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Cat. No. | Product Name | Target | Signaling Pathways |
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T29662 |
Adipiplon
NG-273,NG2-73,NG 2-73,NG 273,NG273,NG-2-73 |
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Adipiplon(NG2-73, NG273) is a novel selective gamma-aminobutyric acid (GABA) partial agonist. | |||
T5643 |
NG25
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MAPK | MAPK |
NG25 是TAK1(IC50:149 nM)和MAP4K2(IC50:21.7 nM)的双抑制剂。 | |||
T69898 | NG25 trihydrochloride | ||
NG25 trihydrochloride is a type II kinase inhibitor that inhibits MAP4K2 and TAK1. It also inhibits the Src family kinases Src and LYN and Abl family kinases as well as CSK, FER, and p38α. NG 25 prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectively. NG 25 decreases cell viability of HCT116KRASWT, and to a greater degree of HCT116KRASG13D, colorectal cancer cells in a concentration... | |||
T73520 |
TNG260
|
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TNG260 是一种CoREST 选择性脱乙酰酶(CoreDAC) 抑制剂。 TNG260 抑制HDAC1的选择性是HDAC3的 10 倍。 TNG260 导致HDAC1抑制,逆转由 STK11 缺失驱动的抗 PD1 耐药性。 TNG260 减少嗜中性粒细胞的瘤内浸润。 TNG260 表现出免疫介导的细胞杀伤。 |
Cat. No. | Product Name | Species | Expression System |
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TMPK-01381 |
CSPG4/MCSP Protein, Cynomolgus, Recombinant (His)
MCSPG,CSPG4,MCSP,NG2 |
Cynomolgus | HEK293 |
The chondroitin sulfate proteoglycan-4 (CSPG4) is a cell surface proteoglycan overexpressed in a huge range of human and canine neoplastic lesions by tumor cells, tumor microenvironment and cancer initiating cells. CSPG4 plays a central role in the oncogenic pathways required for malignant progression and metastatization. | |||
TMPH-01086 |
CSPG4 Protein, Human, Recombinant (His & Myc)
MCSP,Melanoma chondroitin sulfate proteoglycan,Chondroitin s... |
Human | HEK293 |
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and ... | |||
TMPJ-00303 |
ANG2 Protein, Mouse, Recombinant (hFc)
angiopoietin 2,Angiopoietin-2... |
Mouse | Human Cells |
Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Both Ang-2 and the related Angiopoietin-1 (Ang-1) are ligands for the receptor tyrosine kinase Tie-2. While Ang-1 is a potent Tie 2 agonist, Ang-2 may act as either a Tie-2 antagonist or agonist, depending upon its state of multimerization. The higher the order of oligomer, the more effective Ang-2 becomes as a Tie-2 agonist. The short isoform appears to block the binding of... | |||
TMPJ-01435 |
ANG2 Protein, Rhesus macaque, Recombinant (hFc)
ANG-2,Angiopoietin-2,AGP... |
Rhesus Macaque | Human Cells |
Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Both Ang-2 and the related Angiopoietin-1 (Ang-1) are ligands for the receptor tyrosine kinase Tie-2. While Ang-1 is a potent Tie 2 agonist, Ang-2 may act as either a Tie-2 antagonist or agonist, depending upon its state of multimerization. The higher the order of oligomer, the more effective Ang-2 becomes as a Tie-2 agonist. The short isoform appears to block the binding of... |