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4

抑制剂 & 化合物

4

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T29662 Adipiplon

NG-273,NG2-73,NG 2-73,NG 273,NG273,NG-2-73

Adipiplon(NG2-73, NG273) is a novel selective gamma-aminobutyric acid (GABA) partial agonist.
T5643 NG25

MAPK MAPK
NG25 是TAK1(IC50:149 nM)和MAP4K2(IC50:21.7 nM)的双抑制剂。
T69898 NG25 trihydrochloride

NG25 trihydrochloride is a type II kinase inhibitor that inhibits MAP4K2 and TAK1. It also inhibits the Src family kinases Src and LYN and Abl family kinases as well as CSK, FER, and p38α. NG 25 prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectively. NG 25 decreases cell viability of HCT116KRASWT, and to a greater degree of HCT116KRASG13D, colorectal cancer cells in a concentration...
T73520 TNG260

TNG260 是一种CoREST 选择性脱乙酰酶(CoreDAC) 抑制剂。 TNG260 抑制HDAC1的选择性是HDAC3的 10 倍。 TNG260 导致HDAC1抑制,逆转由 STK11 缺失驱动的抗 PD1 耐药性。 TNG260 减少嗜中性粒细胞的瘤内浸润。 TNG260 表现出免疫介导的细胞杀伤。

化合物

Adipiplon
Cat.No: T29662
Synonym: NG-273,NG2-73,NG 2-73,NG 273,NG273,NG-2-73
Target:
NG25
Cat.No: T5643
Synonym:
Target: MAPK
NG25 trihydrochloride
Cat.No: T69898
Synonym:
Target:
TNG260
Cat.No: T73520
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPK-01381 CSPG4/MCSP Protein, Cynomolgus, Recombinant (His)

MCSPG,CSPG4,MCSP,NG2

Cynomolgus HEK293
The chondroitin sulfate proteoglycan-4 (CSPG4) is a cell surface proteoglycan overexpressed in a huge range of human and canine neoplastic lesions by tumor cells, tumor microenvironment and cancer initiating cells. CSPG4 plays a central role in the oncogenic pathways required for malignant progression and metastatization.
TMPH-01086 CSPG4 Protein, Human, Recombinant (His & Myc)

MCSP,Melanoma chondroitin sulfate proteoglycan,Chondroitin s...

Human HEK293
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and ...
TMPJ-00303 ANG2 Protein, Mouse, Recombinant (hFc)

angiopoietin 2,Angiopoietin-2...

Mouse Human Cells
Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Both Ang-2 and the related Angiopoietin-1 (Ang-1) are ligands for the receptor tyrosine kinase Tie-2. While Ang-1 is a potent Tie 2 agonist, Ang-2 may act as either a Tie-2 antagonist or agonist, depending upon its state of multimerization. The higher the order of oligomer, the more effective Ang-2 becomes as a Tie-2 agonist. The short isoform appears to block the binding of...
TMPJ-01435 ANG2 Protein, Rhesus macaque, Recombinant (hFc)

ANG-2,Angiopoietin-2,AGP...

Rhesus Macaque Human Cells
Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Both Ang-2 and the related Angiopoietin-1 (Ang-1) are ligands for the receptor tyrosine kinase Tie-2. While Ang-1 is a potent Tie 2 agonist, Ang-2 may act as either a Tie-2 antagonist or agonist, depending upon its state of multimerization. The higher the order of oligomer, the more effective Ang-2 becomes as a Tie-2 agonist. The short isoform appears to block the binding of...

重组蛋白

CSPG4/MCSP Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-01381
Species: Cynomolgus
Expression System: HEK293
CSPG4 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01086
Species: Human
Expression System: HEK293
ANG2 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-00303
Species: Mouse
Expression System: Human Cells
ANG2 Protein, Rhesus macaque, Recombinant (hFc)
Cat.No: TMPJ-01435
Species: Rhesus Macaque
Expression System: Human Cells
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