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Cat. No.	Product Name	Target	Signaling Pathways
T2043	Mutant IDH1-IN-1 IDH1-IN-1	Dehydrogenase; Isocitrate Dehydrogenase (IDH)	Metabolism
	Mutant IDH1-IN-1 是 IDH1突变体的选择性抑制剂，能够作用于突变体 IDH1 R132C/R132C (IC50:4 nM) ，IDH1 R132H/R132H (IC50:42 nM) ，IDH1 R132H/WT (IC50:80 nM) 和野生型 IDH1 (IC50:143 nM)。
T12128	Mutant IDH1-IN-2	Isocitrate Dehydrogenase (IDH)	Metabolism
	Mutant IDH1-IN-2是突变型异柠檬酸脱氢酶蛋白抑制剂, 在荧光生物化学检测中IC50为16.6 nM，LS-MS 生物化学检测中IC50为＜22 nM,。
T12129	Mutant IDH1-IN-4	Others	Others
	Mutant IDH1-IN-4 is an mutant Isocitrate dehydrogenase 1 (IDH 1) inhibitor.
T39716	Mutant IDH1-IN-6 Mutant IDH1-IN-6
	Mutant IDH1-IN-6 is an orally active compound that effectively inhibits mutant isocitrate dehydrogenase (IDH) enzymes. It demonstrates potency and selectivity, with IC50 values of 6.27, 3.71, 36.9, and 11.5 nM for IDH1 R132H, IDH1 R132C, IDH2 R140Q, and IDH2 R172K mutants, respectively. Notably, Mutant IDH1-IN-6 exhibits lower activity in inhibiting wild-type IDH enzymes.
T16384	Olutasidenib FT-2102	Dehydrogenase; Isocitrate Dehydrogenase (IDH)	Metabolism
	Olutasidenib (FT-2102) 是一种可透过血脑屏障的、具有口服活性的、突变型异柠檬酸脱氢酶(IDH)1的选择性有效抑制剂，对IDH1- R132H 和 IDH1- R132C 的IC50分别为 21.2 nM 和 114 nM，可用于急性髓性白血病或骨髓增生异常综合征的研究。

化合物

Mutant IDH1-IN-1

Cat.No: T2043

Synonym: IDH1-IN-1

Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH)

Mutant IDH1-IN-2

Cat.No: T12128

Target: Isocitrate Dehydrogenase (IDH)

Mutant IDH1-IN-4

Cat.No: T12129

Target: Others

Mutant IDH1-IN-6

Cat.No: T39716

Synonym: Mutant IDH1-IN-6

Cat.No: T16384

Synonym: FT-2102

Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH)

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