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Cat. No.	Product Name	Target	Signaling Pathways
T6897	Monomethyl auristatin E 一甲基澳瑞他汀E,Vedotin,MMAE	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Monomethyl auristatin E (MMAE) 是海兔毒素 10 的合成衍生物，是一种抗有丝分裂剂，通过阻断微管蛋白的聚合来抑制细胞分裂，并且还具有抑制抗体-药物偶联物的活性。
T10948	MMAE-d8 D8-MMAE,D8-Monomethyl auristatin E	Others	Others
	D8-MMAE (D8-Monomethyl auristatin E) is an effective mitotic inhibitor and tubulin inhibitor, deuterated MMAE.
T18312	Mc-MMAE Maleimidocaproyl-monomethylauristatin E,马来酰亚胺基己酰-单甲基澳瑞他汀 E	Microtubule Associated	Cytoskeletal Signaling
	Mc-MMAE (Maleimidocaproyl-monomethylauristatin E) 是保护基团 (马来酰亚氨基己酰) 与 MMAE 共轭连接得到的化合物。它是微管蛋白抑制剂，可用于偶联抗体。
T40568	Fmoc-MMAE
	Fmoc-MMAE, a protective group-conjugated variant of monomethyl auristatin E (MMAE), serves as a powerful inhibitor of tubulin. It finds application in the synthesis of antibody-drug conjugates (ADC).
T18736	SuO-Val-Cit-PAB-MMAE	Others	Others
	SuO-Val-Cit-PAB-MMAE is an ADC (antibody-drug conjugate) linker comprising the anti-mitotic monomethyl auristatin E (MMAE, a tubulin inhibitor) connected through the SuO-Val-Cit-PAB peptide.
T18679	SC-VC-PAB-MMAE	Others	Others
	SC-VC-PAB-MMAE is a potent antitumor drug-linker conjugate for antibody-drug conjugates (ADCs), comprising the anti-mitotic agent monomethyl auristatin E (MMAE, a tubulin inhibitor) connected through the cleavable linker SC-VC-PAB[1].
T17817	DBCO-(PEG)3-VC-PAB-MMAE	Others	Others
	DBCO-(PEG)3-VC-PAB-MMAE is a chemical compound where monomethyl auristatin E (MMAE), a potent tubulin inhibitor acting as a toxin payload in antibody-drug conjugates, is conjugated to a DBCO-(PEG)3-vc-PAB linker.
T39307	Azido-PEG4-Val-Cit-PAB-MMAE Azido-PEG4-Val-Cit-PAB-MMAE
	Azido-PEG4-Val-Cit-PAB-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADCs), comprising the anti-mitotic agent monomethyl auristatin E (MMAE, a tubulin inhibitor), connected through the cleavable linker Azido-PEG4-Val-Cit-PAB-OH.
T70958	Dov-Val-Dil-OH TFA
	Dov-Val-Dil-OH is a useful chemical intermediate for synthesis of auristatin-related compounds, such as Monomethyl auristatin E (MMAE), Auristatins are antimitotic agents which inhibits cell division by blocking the polymerisation of tubulin.
T77838	Telisotuzumab vedotin ABBV-399
	Telisotuzumab vedotin (ABBV-399) 是一种靶向c-Met的抗体-药物偶联物（ADCs），由Monomethyl Auristatin E (MMAE)、Telisotuzumab抗体和mc-val-cit-PABC可裂解型linker组合而成，主要用于癌症研究。
T82384	Fmoc-Gly3-VC-PAB-MMAE
	Fmoc-Gly3-VC-PAB-MMAE 是一款用于 ADC 的药物-连接子偶联物，由 MonomethylauristatinE 和连接子构成。
T18303	Mal-Phe-C4-VC-PAB-MMAE	Others	Others
	Mal-Phe-C4-VC-PAB-MMAE is a chemical compound resulting from the conjugation of monomethyl auristatin E (MMAE), a potent tubulin inhibitor serving as a toxin payload in antibody-drug conjugates, with a Mal-Phe-C4-VC-PAB linker.
T81753	mp-dLAE-PABC-MMAE
	mp-dLAE-PABC-MMAE 是构成抗体药物偶联物 (ADC) 活性部分的化合物。它包括微管蛋白抑制剂 Monomethylauristatin E，并用于ADC的合成。
T82380	Fmoc-VAP-MMAE
	Fmoc-VAP-MMAE是一种含有微管蛋白抑制剂MMAE的ADC活性分子-linker偶联物，配备了Fmoc保护基团。该复合物由ADC Linker和MMAE构成。
T18473	N3-PEG3-vc-PAB-MMAE	Others	Others
	N3-PEG3-vc-PAB-MMAE, a drug-linker conjugate designed for Antibody-Drug Conjugates (ADC), features the integration of monomethyl auristatin E (MMAE), a tubulin inhibitor, via a 3-unit polyethylene glycol (PEG) linker. This compound demonstrates significant antitumor activity.
T79039	GGGDTDTC-Mc-vc-PAB-MMAE
	GGGDTDTC-Mc-vc-PAB-MMAE为一种ADC药物-连接物偶联物，主要由微管蛋白抑制剂Monomethylauristatin E (MMAE)组成。
T77883	Val-Ala-PAB-MMAE
	Val-Ala-PAB-MMAE是一种用于抗体药物偶联物(ADC)的药物连接物缀合物，由ADC连接子(Val-Ala-PAB)与微管抑制剂MMAE构成。
T17789	DBCO-(PEG2-VC-PAB-MMAE)2	Others	Others
	DBCO-(PEG2-VC-PAB-MMAE)2 consists of Monomethyl auristatin E (MMAE), a toxin payload in antibody-drug conjugate [1], conjugated to the cleavable linker DBCO-(PEG2-VC-PAB)2. MMAE, a potent tubulin inhibitor, serves as the cytotoxic component in this formulation.
T77853	MC-VA-PABC-MMAE
	MC-VA-PABC-MMAE是一种ADC(Linker为peptide MC-VA-PABC)的活性分子，由Linker与高效微管蛋白抑制剂MMAE通过偶联反应形成。
T81361	PSMA-Val-Cit-PAB-MMAE
	PSMA-Val-Cit-PAB-MMAE是一种靶向前列腺特异性膜抗原（PSMA）的小分子化合物，用MMAE作为药效基团进行前列腺癌治疗。
T77823	Polatuzumab vedotin
	Polatuzumab vedotin是一种抗体药物偶联物，靶向CD79b。该化合物结合了人源化抗CD79b IgG1单克隆抗体和微管抑制剂monomethyl auristatin E (MMAE)，展现出针对大B细胞淋巴瘤（LBCL）的治疗潜力。
T81133	Sofituzumab vedotin DMUC5754A
	Sofituzumab vedotin (DMUC5754A) 是一种抗MUC16的ADC，其含有MMAE并配备蛋白酶切割连接子。该化合物主要应用于癌症研究领域。
T77881	Tisotumab vedotin
	Tisotumab vedotin是一种针对组织因子（tissue factor, TF）的抗体-药物偶联物（ADC），由全人源单克隆抗体(TF-011)与Monomethyl Auristatin E (MMAE)耦合而成，具有显著抗肿瘤活性，适用于晚期或转移性实体瘤的治疗研究。
T15872	m-PEG4-Br	Others	Others
	m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab. m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in v
T80609	Mecbotamab
	Mecbotamab是一款针对AXL受体酪氨酸激酶的人源化IgG1-κ抗体。作为条件活性生物制剂(CAB)，Mecbotamab通过一个可降解连接子与MMAE结合，组成ADC（抗体-药物偶联物）产品Mecbotamab vedotin (BA3011)。
T82582	Depatuxizumab MMAE
	Depatuxizumab MMAE 是抗EGFR抗体 (Depatuxizumab) 与 Monomethylauristatin E (MMAE) 结合形成的抗体-活性分子偶联物 (ADC)，能够抑制EGFRvIII突变型以及野生型EGFR在异种移植瘤模型中的生长。
T77856	Ac-Lys-Val-Cit-PABC-MMAE
	Ac-Lys-Val-Cit-PABC-MMAE作为一种抗体偶联药物(ADC)的活性分子部分，由ADC连接子（肽 Ac-Lys-Val-Cit-PABC）与微管蛋白聚合抑制剂MMAE经偶联形成。
T77857	Ac-Lys-Val-Cit-PABC-MMAE formic
	Ac-Lys-Val-Cit-PABC-MMAE (formic) 为一种抗体药物偶联物（ADC）的活性组分。该化合物是由ADC链接子（肽类Ac-Lys-Val-Cit-PABC）与微管蛋白聚合抑制剂Monomethylauristatin E (MMAE) 结合而得。
T77186	Zilovertamab vedotin
	Zilovertamab vedotin (VLS-101) 是一种抗体-活性分子偶联物 (ADC), 主要由人源化单克隆抗体 zilovertamab 和单甲基 vedotin 组成的抗微管细胞毒素。该药物通过与肿瘤细胞表面的ROR1结合, 触发快速内化及向溶酶体的转运, 进而裂解释放单甲基 vedotin, 诱导细胞凋亡。适用于癌症的研究领域。

化合物

Monomethyl auristatin E

Cat.No: T6897

Synonym: 一甲基澳瑞他汀E,Vedotin,MMAE

Target: Apoptosis, Microtubule Associated

Cat.No: T10948

Synonym: D8-MMAE,D8-Monomethyl auristatin E

Target: Others

Cat.No: T18312

Synonym: Maleimidocaproyl-monomethylauristatin E,马来酰亚胺基己酰-单甲基澳瑞他汀 E

Target: Microtubule Associated

Cat.No: T40568

SuO-Val-Cit-PAB-MMAE

Cat.No: T18736

Target: Others

Cat.No: T18679

Target: Others

DBCO-(PEG)3-VC-PAB-MMAE

Cat.No: T17817

Target: Others

Azido-PEG4-Val-Cit-PAB-MMAE

Cat.No: T39307

Synonym: Azido-PEG4-Val-Cit-PAB-MMAE

Dov-Val-Dil-OH TFA

Cat.No: T70958

Telisotuzumab vedotin

Cat.No: T77838

Synonym: ABBV-399

Fmoc-Gly3-VC-PAB-MMAE

Cat.No: T82384

Mal-Phe-C4-VC-PAB-MMAE

Cat.No: T18303

Target: Others

mp-dLAE-PABC-MMAE

Cat.No: T81753

Cat.No: T82380

N3-PEG3-vc-PAB-MMAE

Cat.No: T18473

Target: Others

GGGDTDTC-Mc-vc-PAB-MMAE

Cat.No: T79039

Val-Ala-PAB-MMAE

Cat.No: T77883

DBCO-(PEG2-VC-PAB-MMAE)2

Cat.No: T17789

Target: Others

MC-VA-PABC-MMAE

Cat.No: T77853

PSMA-Val-Cit-PAB-MMAE

Cat.No: T81361

Polatuzumab vedotin

Cat.No: T77823

Sofituzumab vedotin

Cat.No: T81133

Synonym: DMUC5754A

Tisotumab vedotin

Cat.No: T77881

Cat.No: T15872

Target: Others

Cat.No: T80609

Depatuxizumab MMAE

Cat.No: T82582

Ac-Lys-Val-Cit-PABC-MMAE

Cat.No: T77856

Ac-Lys-Val-Cit-PABC-MMAE formic

Cat.No: T77857

Zilovertamab vedotin

Cat.No: T77186

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