Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1102 |
Mifepristone
C-1073,RU486,RU 38486,米非司酮 |
Glucocorticoid Receptor; Estrogen/progestogen Receptor; Progesterone Receptor; NO Synthase; Autophagy | Autophagy; Endocrinology/Hormones; Immunology/Inflammation; Others |
Mifepristone (C-1073) 是一种黄体酮受体和糖皮质激素受体拮抗剂,在体外实验中的 IC50值分别为 0.2 nM 和 2.6 nM。 | |||
T71460 | Mifepristone methochloride | ||
Mifepristone methochloride is a glucocorticoid antagonist. This product will be sold for research use only. | |||
T80652 |
N-Demethyl Mifepristone
RU 42633 |
Glucocorticoid Receptor | Endocrinology/Hormones |
N-Demethyl Mifepristone (RU 42633) 为一种Mifepristone的活性代谢产物,其对糖皮质激素受体 (glucocorticoid receptor) 的亲和力相对于Mifepristone (100%) 为61%。 | |||
T20855 |
Gemeprost
SC-37681,SC 37681,Carprost,Gemeprostum,Cervagem,Preglandin |
||
Gemeprost, an analog of prostaglandin E1, is used for the treatment of obstetric bleeding. It is used to terminate pregnancy up to 24 weeks gestation together with mifepristone. | |||
T21132 | Aglepristone | ||
Aglepristone is a synthetic steroidal antiprogestogen related to mifepristone and possesses some antiglucocorticoid activity. It is specifically used as an abortifacient in pregnant animals. | |||
T69895 | Lonaprisan | ||
Lonaprisan is an orally bioavailable pentafluoroethyl derivative of a mifepristone-related steroid with antiprogestagenic activity. Lonaprisan is a pure, highly receptor-selective progesterone receptor (PR) antagonist; binding of this agent to PRs inhibits PR activation and the associated proliferative effects. Unlike many other antiprogestins such as mifepristone, this agent does not appear to convert to an agonist in the presence of protein kinase A (PKA) activators and shows high antiprogesta... |