Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2643 |
MI-3
Menin-MLL Inhibitor,Menin-MLL inhibitor 3,MI 3 |
Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase | Apoptosis; Chromatin/Epigenetic |
MI-3 (Menin-MLL Inhibitor)是一种有高亲和力的 menin-MLL 抑制剂,IC50值为 648 nM,Kd 值为 201 nM。 | |||
T15831 |
M-525
|
Others | Others |
M-525 binds to menin (IC50: 3 nM) and achieves low nanomolar potencies in cell growth inhibition and in the suppression of MLL regulated gene expression in MLL leukemia cells. M-525 is a first-in-class, highly potent, irreversible, and covalent menin-MLL |