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Cat. No. | Product Name | Target | Signaling Pathways |
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TP1261 |
Alexamorelin Met 1
(D-Mrp)-Ala-Trp-(D-Phe) |
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Alexamorelin Met 1 is one of the metabolites of alexamorelin. The heptapeptide Ala-His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2 (Alexamorelin) is a synthetic molecule which inhibits growth hormone secretagogue binding in vitro. | |||
T27946 |
LY-329146
LY 329146 |
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LY-329146 is a selective estrogen receptor modulator (SERM). LY-329146 prevents doxorubicin resistance in tumor cells expressing multidrug resistance-associated protein (MRP) by inhibiting the binding of MRP substrates to the estrogen receptor. | |||
T14616 |
Biricodar
VX-710 |
Others | Others |
Biricodar is a P-glycoprotein and MRP-1 modulator. | |||
T26339L |
XR-11576 HCl
XR-11576 HCl(346689-77-8 Free base) |
Topoisomerase | DNA Damage/DNA Repair |
XR-11576 HCl 是一种新型口服活性拓扑异构酶I 和II 双重抑制剂,具有抗肿瘤活性。 | |||
T36807 |
Estradiol 17-(β-D-Glucuronide) (sodium salt hydrate)
|
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Estradiol 17-(β-D-glucuronide) (E217G) is an estrogen metabolite formed in the liver and subsequently excreted in bile.1It acts as a substrate of the multidrug resistance protein 2 (MRP2; Km= 75 μM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow.1,2In addition to binding to the MRP2 transport site, E217G has been shown to bind to an allosteric site that through positive cooperativity activates its own transportviaMRP2 and the transport of other MRP2 ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1863 |
Licoisoflavone A
Phaseoluteone |
MRP | Immunology/Inflammation |
Licoisoflavone A (Phaseoluteone) 是一种 MRP 抑制剂,可抑制脂质过氧化,IC50 为 7.2 μM。 | |||
T19866 |
Indican
NSC-87517,3-Indoxyl-beta-D-glucopyranoside,3-吲哚基-beta-D-吡喃葡萄糖苷,NSC 87517,NSC87517,Indoxyl-β-D-glucoside |
OAT; MRP | Immunology/Inflammation; Membrane transporter/Ion channel |
Indican (Indoxyl-β-D-glucoside) 是吲哚酚的一种糖苷,染料靛蓝和靛玉红的前体。它的主要代谢物是硫酸吲哚酚 (IS)。其中 IS 是尿毒症毒素,是有机阴离子转运蛋白1 (OAT 1)、OAT 3 和多药耐药相关蛋白4 (MRP 4) 的底物/抑制剂。 | |||
T4A2399 |
Cinobufotalin
华蟾毒它灵,华蟾素 |
IL Receptor; Akt; MRP; P-gp | Cytoskeletal Signaling; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; PI3K/Akt/mTOR signaling |
Cinobufotalin 是一种从蟾蜍的皮肤分泌物中提取的强心类固醇或丁二烯内酯。它已被用作强心药,利尿药和止血药,也是潜在的抗肺癌药物。 | |||
TN2219 |
Sophoraisoflavone A
鲁冰花,砂生槐异黄酮 A |
MRP; Antifection | Immunology/Inflammation; Microbiology/Virology |
Sophoraisoflavone A is a potential MRP inhibitor; it is also an inhibitor of germ tube growth in the AM fungus Gigaspora margarita, it strongly inhibited germ tube growth at 1.25 ug/disc. Sophoraisoflavone A shows inhibitory effects on copper-induced prot | |||
T15097 |
Deoxynivalenol
Vomitoxin,4-Deoxynivalenol |
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Deoxynivalenol (Vomitoxin) 是一种单端孢菌素家族镰刀菌属产生的霉菌毒素,常见于受到污染的食物和饲料中。Deoxynivalenol 通过紧密连接处的细胞旁路来穿过肠粘膜。Deoxynivalenol 转运不受P-糖蛋白 (PgP) 或多药耐药相关蛋白 (MRP) 抑制剂的影响。Deoxynivalenol 通常会导致人类和动物腹泻、呕吐和胃肠道炎症。 |