Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T76653 |
Polybia-MP1
|
||
Polybia-MP1 是一种抗菌素乳苦菌肽。 | |||
T80585 |
Anti-Mouse GM-CSF Antibody (MP1-22E9)
|
c-Fms | Tyrosine Kinase/Adaptors |
Anti-MouseGM-CSFAntibody 为特异性针对小鼠GM-CSF的IgG2a类免疫球蛋白抗体,由大鼠血清中提取。 | |||
T69977 |
BC-1485
|
||
BC-1485 is a first-in-class inhibitor of Fibrosis-inducing E3 ligase 1 (FIEL1 ), which disrupts FIEL1-directed PIAS4 ubiquitination. | |||
T71901 |
MP-1
|
||
MP-1 is a covalent inhibitor of fumarate hydratase (FH) that exhibits cytotoxicity dependent on FH. MP-1 engages a functional cysteine in the Zn-finger domain of the tRNA methyltransferase enzyme TRMT1. | |||
T16124 |
MMP13-IN-3
|
MMP | Proteases/Proteasome |
MMP13-IN-3 是口服有效的MMP-13选择性抑制剂,IC50为 1 nM,比其他 MMP 的选择性高 1000倍多。MMP13-IN-3在用于骨关节炎方面有研究的价值。 | |||
T3983 |
TMP195
TFMO 2,TMP 195 |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
TMP195 (TFMO 2) 是一种选择性 IIa 类组蛋白脱乙酰酶 (HDAC) 抑制剂。对 HDAC4、HDAC5、HDAC7,HDAC9的 Ki 值分别为59、60、26,5 nM。 | |||
T78269 |
Anti-Mouse PD-1 Antibody (RMP1-14)
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
RMP1-14 是一种 IgG1 样免疫球蛋白抗小鼠 PD-1 抗体,可阻断 PD-1/PD-L1 信号传导。 | |||
T41079 |
MMP13-IN-2
MMP13-IN-2 |
||
MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases. | |||
T76244 |
Amp1EP9
|
||
Amp1EP9为一抗菌肽,作为开发有效无毒抗菌活性分子的强大工具,具备针对多重耐药细菌感染进行研究的潜力。 | |||
T80282 |
cPcAMP1/26
|
||
cPcAMP1/26 是一款抗菌肽,能高效清除A.Hydrophila及金黄色葡萄球菌 (S. aureus)。该化合物通过诱导细菌质膜去极化作用并提升细胞内ROS水平,展示其抗菌机制。 | |||
T78775 |
MMP13-IN-5
|
MMP | Proteases/Proteasome |
MMP13-IN-5 (compound 13m) 作为具有针对性的MMP-2/MMP-13 抑制剂,显示出高效的抑制活性(IC50=3.6 μM/14.6 μM),适用于骨关节炎疼痛的研究。 | |||
T83487 |
[Pmp1,Tyr(OEt)2] AVP
|
||
[Pmp1,Tyr(OEt)2] AVP为环状加压素(AVP)的线性拮抗剂,具备相似结构。 | |||
T78774 | MMP13-IN-4 | MMP | Proteases/Proteasome |
MMP13-IN-4(compound 13)作为MMP-13抑制剂,具备强效性和选择性,其IC50值为14.6 μM,可用于骨关节炎疼痛的研究。 | |||
T72306 |
Mycobacterial Zmp1-IN-1
|
||
Mycobacterial Zmp1-IN-1 是一种分枝杆菌锌金属蛋白酶-1(Zmp1)抑制剂。Mycobacterial Zmp1-IN-1 对 MtbH37Ra 具有剂量依赖性抑制的抗分枝杆菌活性。Mycobacterial Zmp1-IN-1 可用于结核病 (TB) 的研究。 | |||
T80336 |
DFTamP1
|
||
DFTamP1为抗菌肽,针对金黄色葡萄球菌USA300表现出活性,其最小抑菌浓度(MIC)为3.1 μM。 | |||
T82063 |
Integrin signaling inhibitor, mP13
|
||
Integrinsignaling inhibitor, mP13 是抑制整合素信号传导,阻止内向外和外向内信号传递,涉及纤维蛋白原结合、血小板粘附及凝块收缩的化合物。 |