首页工具

登录

搜索结果

Search Results for " mdp "

Targets Recommended: NOD

20

抑制剂 & 化合物

2

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T16159	Muramyl dipeptide MDP	NOD	Immunology/Inflammation; NF-κB
	Muramyl dipeptide (MDP) 是合成的免疫反应肽，由 N-乙酰壁酸与 L-Ala-D-isoGln 的短氨基酸链相连。它通过MAPK 途径上调 Runx2 基因表达，直接促进成骨细胞分化，通过降低 RANKL/OPG 比值间接抑制破骨细胞分化。它是通过Runx2诱导骨形成的诱导因子，也是NLRP1激动剂。
T74731	L18-MDP
	L18-MDP，一种胞壁酰二肽衍生的抗菌剂，展现了抗菌活性，可能在细菌及真菌感染中应用。
TP2405	Romurtide MDP-lys(L18),CCRIS 1220,DJ-7041,Nopia
	Romurtide is a synthetic muramyl dipeptide analog and can be used for the prophylaxis of leukocytopenia during radiation therapy.
T38361	GSK717	IL Receptor; NOD	Immunology/Inflammation; NF-κB
	GSK717 是 NOD2(核苷酸结合寡聚结构域 2) 的选择性抑制剂。它抑制壁酰二肽 (MDP) 诱导的 NOD2 介导的信号转导，抑制 MDP 刺激的 HEK293/hNOD2 细胞分泌 IL-8 (IC50为 400 nM)。
T37804	8MDP
	Potent equilibrative nucleoside transporter 1 (ENT1) inhibitor (IC50 = 0.43 nM). Inhibits hENT1 and hENT2 uptake of [H3]uridine in K562 cells and K15NTD cells respectively. Lin et al (2011) Design, synthesis, and evaluation of 2-diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein conjugate (8MDP-fluor), as a novel equilibrativ Bioconjug.Chem. 22 1221 PMID:21539390 \|Lin et al (2007) Synthesis, flow cytometric evaluat...
T76219	MDP1
	MDP1是一种源自蜂毒肽(melittin)的衍生肽，具有破坏革兰氏阳性及阴性细菌膜完整性的能力，能够通过膜损伤方式杀灭细菌。该化合物对金黄色葡萄球菌、大肠杆菌以及铜绿假单胞菌的耐多药(MDR)和参考菌株显示出高度的抗菌活性。
T76219L	MDP1 acetate
	MDP1 acetate为一种基于蜂毒肽(melittin)的衍生肽，能够破坏革兰氏阳性及革兰氏阴性细菌的膜完整性，进而通过膜损伤机制杀灭细菌。该化合物对金黄色葡萄球菌、大肠杆菌及铜绿假单胞菌等耐多药(MDR)与标准菌株表现出显著的抗菌活性。
T13856	(R)-DNMDP	Others	Others
	(R)-DNMDP is a potent and selective agent of cancer cell cytotoxic.
T27344	FMDP
	FMDP is a glucosamine-6-phosphate synthase inhibitor.
T28007	MDPD
	MDPD is an enhancer of the N-acylethanolamine degrading enzyme, fatty acid amide hydrolase, in Arabidopsis. MDPD alleviates the growth inhibitory effects of NAE 12:0, in part by enhancing the enzymatic activity of Arabidopsis FAAH (AtFAAH).
T15147	DNMDP	Others	Others
	DNMDP is a phosphodiesterase 3A inhibitor with clear cell-selective cytotoxicity. DNMDP binding to PDE3A promotes interaction between PDE3A and Schlafen 12.
T18333	mDPR(Boc)-Val-Cit-PAB	Others	Others
	mDPR(Boc)-Val-Cit-PAB is a cleavable linker employed in antibody-drug conjugates (ADCs) [1]. This chemical compound serves as a reliable linker in the formation of ADCs, which are biopharmaceuticals that combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs for targeted cancer therapy [1].
T67428	mDPR-Val-Cit-PAB-MMAE
	mDPR-Val-Cit-PAB-MMAE consists the ADCs linker (mDPR-Val-Cit-PAB) and potent tubulin inhibitor (MMAE), mDPR-Val-Cit-PAB-MMAE is an antibody drug conjugate.
T79600	Zharp2-1	RIP kinase	Apoptosis; NF-κB
	Zharp2-1是一种 RIPK2 抑制剂，抑制了 MDP 诱导或单核细胞增生李斯特菌感染诱导的炎症细胞因子的转录，缓解MDP诱导的小鼠腹膜炎症状，可用于研究炎症性肠病 (IBD)。
T77644	AJ2-30	Others	Others
	AJ2-30是一种 SLC15A4 抑制剂，抑制 TLR9 介导的 B 细胞活化，抑制 MDP 转运。AJ2-30 抑制人和小鼠巨噬细胞中的内源性 NOD 信号传导。AJ2-30 可用于研究炎症。
T77782	MOTS-c
	MOTS-c为源于线粒体的多肽（MDP），它通过激活AMPK途径并抑制MAP激酶-c-fos信号通路，具有抗损伤和抗炎效应。
T63088	NOD2 antagonist 1
	NOD2 antagonist 1 (compound 32) 是一种有效的、选择性的 NOD2 拮抗剂 (IC50: 5.23 μM)。NOD2 antagonist 1 在 THP-1 细胞，对 Muramyl dipeptide (MDP) 诱导的 IL-8 分泌表现出抑制作用。NOD2 antagonist 1 在 PBMCs 细胞，可以抑制 MDP 诱导的 IL-6、IL-10 和 TNF-α 的水平升高。
T83152	AJ2-71
	AJ2-71为SLC15A4抑制剂，具有抑制IFN-α产生的能力，并能阻断SLC15A4介导的MDP转运，适用于炎症研究。
T74089	Mifamurtide TFA
	Mifamurtide TFA (MTP-PE TFA) 是穆拉基二肽 (MDP) 的类似物，一种非特异性免疫调节剂，通过刺激激活巨噬细胞和单核细胞的免疫应答而发挥作用。Mifamurtide TFA 是一种孤儿药，是 NOD2的特异性配体，用作胰岛素增敏剂。Mifamurtide TFA 具有用于骨肉瘤研究的潜力。
T73862	Almurtide
	Almurtide (nor-MDP)是一种来源于胞壁酰二肽的化合物，展现出抗炎及抗肿瘤的特性。此外，Almurtide可有效防护小鼠免受铜绿假单胞菌腹腔内感染和白色念珠菌静脉感染，亦对致癌性Friend白血病病毒表现出抑制力。

化合物

Muramyl dipeptide

Cat.No: T16159

Synonym: MDP

Target: NOD

Cat.No: T74731

Cat.No: TP2405

Synonym: MDP-lys(L18),CCRIS 1220,DJ-7041,Nopia

Cat.No: T38361

Target: IL Receptor, NOD

Cat.No: T37804

Cat.No: T76219

Cat.No: T76219L

Cat.No: T13856

Target: Others

Cat.No: T27344

Cat.No: T28007

Cat.No: T15147

Target: Others

mDPR(Boc)-Val-Cit-PAB

Cat.No: T18333

Target: Others

mDPR-Val-Cit-PAB-MMAE

Cat.No: T67428

Cat.No: T79600

Target: RIP kinase

Cat.No: T77644

Target: Others

Cat.No: T77782

NOD2 antagonist 1

Cat.No: T63088

Cat.No: T83152

Mifamurtide TFA

Cat.No: T74089

Cat.No: T73862

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01205	MDP1 Protein, Human, Recombinant (His) Magnesium-dependent phosphatase 1,MDP-1,EC=3.1.3.48	Human	HEK293 Cells
	MDP1, which is short for nesium-dependent phosphatase 1, is a 176 aa. protein. It has 3 forms by different alternative splicing. This protein belongs to the HAD-like hydrolase superfamily, and usually takes its function with Magnesium. It can be inhibited by vanadate and zinc, and slightly by calcium. MDP1 is a Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.
TMPY-03329	DPEP1 Protein, Human, Recombinant (His) MBD1,dipeptidase 1,MDP,RDP	Human	HEK293 Cells
	Dehydropeptidase-I, also known as DPEP1, is a kidney membrane enzyme. Its expression in normal colonic mucosa is very low, but it is highly expressed in colorectal adenoma and cancer specimens and is negatively correlated with parameters of pathological aggressiveness and poor prognosis. The overexpression of DPEP1 suppressed tumor cells invasiveness and increased sensitivity to chemotherapeutic agent Gemcitabine. Growth factor EGF treatment decreased DPEP1 expression. Dehydropeptidase-I m...

重组蛋白

MDP1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01205

Species: Human

Expression System: HEK293 Cells

DPEP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03329

Species: Human

Expression System: HEK293 Cells

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼