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Cat. No. | Product Name | Target | Signaling Pathways |
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T72319 |
Lewis y tetrasaccharide
Lewis y |
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Lewis Y tetrasaccharide (Lewis Y, LeY) 是Lewis X trisaccharide 的四糖衍生物。Lewis Y tetrasaccharide 是一种与恶性卵巢癌转移和预后不良相关的抗原。 | |||
T35884 |
Sialyl-Lewis X
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Sialyl-Lewis X (sLeX), a sialylated fucosylated tetrasaccharide and endogenous antigen, serves as a high-affinity ligand for selectins (E-, P-, and L-selectin)[1]. It interacts with ELAM-1 and CD62, consequently inhibiting CD62-mediated neutrophil recruitment to inflammation sites[2]. | |||
T77243 | Sialyl lewis x-lactose | ||
Sialyl Lewis X-Lactose 是一种生化试剂,可作为生物材料或有机化合物,用于生命科学相关研究。 | |||
T9616 |
PD-1/PD-L1-IN-10
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PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
PD-1/PD-L1-IN-10 是一种口服有效的PD-1/PD-L1抑制剂 (IC50of 2.7 nM),显示出抗肿瘤活性。 | |||
T73592 |
N′-(2-Chloroethyl)-N-(4-methylcyclohexyl)-N-nitrosourea
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N′-(2-Chloroethyl)-N-(4-methylcyclohexyl)-N-nitrosourea 具有抗肿瘤活性,可用于治疗 Lewis 肺癌和结肠肿瘤。 | |||
TP1358L |
Peptide M acetate
Peptide M acetate(110652-62-5 free base),Peptide M 醋酸盐 |
Others | Others |
Peptide M acetate 是一种合成多肽 (长度为 18 个氨基酸,对应于牛 S 抗原的氨基酸位置303-322: DTNLASSTIIKEGIDKTV),能够在猴子和 Hartley 豚鼠以及 Lewis 大鼠中诱导实验性自身免疫性葡萄膜炎。 | |||
T40925 |
Peripheral Myelin Protein P2 (53-78), bovine
Peripheral Myelin Protein P2 (53-78), bovine |
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Bovine Peripheral Myelin Protein P2 (53-78) is a derivative composed of amino acid residues 53 to 78 from the peripheral myelin P2 protein of bovine origin. It acts as a T cell epitope and is used to induce experimental autoimmune neuritis (EAN) in Lewis rats. | |||
T83334 |
4-(Phenylazo)diphenylamine
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4-(Phenylazo)diphenylamine 是一种用于准确测定强碱、路易斯酸和氢化物还原剂浓度的优异比色指示剂。 | |||
T37542 |
Anguinomycin A
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Anguinomycin A is an antibiotic first isolated from a Streptomyces sp. and analog of leptomycin B that is highly cytotoxic to mouse P388 leukemia cells in vitro (IC50 = 0.1-0.2 ng/ml). It also demonstrates antitumor activity at 62.5 μg/kg/day against Lewis lung carcinoma in mice. | |||
T36040 |
16,16-dimethyl Prostaglandin A1
16,16-dimethyl Prostaglandin A1 |
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16,16-dimethyl Prostaglandin A1 是一种前列腺素类似物,可以抑制 Lewis 肺癌和 B 16无黑色素瘤细胞中的 DNA 合成 (DNA synthesis),以及抑制 HSV 和 HIV-1的病毒复制。 | |||
TP1974 |
Obtustatin
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Highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitum | |||
T68631 | Carbetimer | ||
Carbetimer is a partially imidized copolymer of ethylene & maleic anhydride with average MW approx 1,200 daltons; capable of specific stimulation of immune response. Carbetimer is a low molecular weight polymer derived from ethylene and maleic anhydride with potent antineoplastic activity. Preclinical studies have shown antitumor effects against many tumor cell lines including B 16 melanoma. Its antitumor actions are felt to include both reduction of uridine and cytidine nucleoside triphosphate ... | |||
T36460 |
CAY10736
CAY10736 |
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CAY10736 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM). CAY10736 inhibits migration and epithelial-to-mesenchymal transition (EMT) of A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 2.4 and 1.59 μM, respectively) and increases the production of reactive oxygen species (ROS) in these cells in a ... | |||
T36497 |
CAY10735
CAY10735 |
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CAY10735 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mesenchymal transition (EMT) in A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 3.04 and 1.24 μM, respectively) and increases production of reactive oxygen species (ROS) in these cells ... | |||
T37631 |
tetranor-12(S)-HETE
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12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix. tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE in numerous tissues, and Lewis lung carcinoma cells. No biological function has yet been determined for tetran... | |||
T69966 |
Roxadustat-d5
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Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is selective for HIF-PH over other 2-oxoglutarate-dependent dioxygenases, including lysine-specific demethylase 5A (KDM5A), KDM5B, -5C, -5D, and -6B (IC50s = >100 µM for all). Roxadustat (10-200 µM) stabilizes HIF-1α and ... | |||
T36695 |
TAS-103
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TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells[1]. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103[2]. TAS-103 inhibits the viability ... | |||
T36053 |
D-Lysine lactam
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D-Lysine lactam is a chiral building block.1,2It has been used in the synthesis of a chiral antibiotic synthetic intermediate, as well as in the stereoselective synthesis of neurokinin (NK) receptor antagonists. 1.Kumar, A., Bhashkar, B., Bhavsar, J., et al.Catalytic reduction: Efficient synthesis of chiral key intermediate of besifloxacin hydrochlorideDer Pharma Chemica7(9)297-3000(2015) 2.Gerspacher, M., Lewis, C., Ball, H.A., et al.Stereoselective preparation of N-[(R,R)-(E)-1-(3,4-dichlorobe... | |||
T36373 |
Urocortin II (mouse) (trifluoroacetate salt)
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Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.1 Mouse urocortin II shares 34 and 42% sequence homology with rat CRF and urocortin . It is expressed in mouse paraventricular, supraoptic, and arcuate nuclei of the hypothalamus, the locus coeruleus, and in motor nuclei of the brainstem and spinal ventral horn. Urocortin II selectively binds to CRF... | |||
T35814 |
Urocortin III (human) (trifluoroacetate salt)
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Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin II , frog sauvagine, and piscine urotensin I.1 Human urocortin III shares 90, 40, 37, and 21% identity to mouse urocortin III , mouse urocortin II , human urocortin , and mouse urocortin, respectively. Urocortin III selectively binds to type 2 CRF receptors (Kis = 21.7, 13.5, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively).... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T81937 |
Lewis a trisaccharide
Lewis a |
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Lewis a trisaccharide 是精子聚糖结构和 HL-60 细胞表面聚糖结构的主要组分。 | |||
T7203 |
Oglufanide
奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH |
VEGFR; HCV Protease; Endogenous Metabolite | Angiogenesis; Metabolism; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Oglufanide (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来的二肽免疫调节剂,可抑制血管内皮生长因子,可刺激细胞内细菌感染和对丙型肝炎病毒的免疫反应。 | |||
T75670 | Lacto-N-fucopentaose II | ||
Lacto-N-fucopentaose II (LNFP II)作为人Lewis血型决定因子的半抗原,其单唾液神经节苷/糖脂以及唾液酰衍生物CA 19-9,都是胆胰恶性肿瘤中的分子肿瘤标记物(TM)。 | |||
T81961 |
Lacto-N-difucohexaose I
LDFH I |
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LNDFH I是一种连接子,它能够将含Lewis b糖链的寡糖有效结合形成水不溶性多糖。 | |||
TN4455 |
Lucialdehyde B
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Integrase; HSV | Microbiology/Virology |
Lucialdehyde B exhibits potent inhibitory activity against herpes simplex virus. It shows cytotoxic effects on Lewis lung carcinoma (LLC), T-47D, Sarcoma 180, and Meth-A tumor cell lines. |