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Cat. No.	Product Name	Target	Signaling Pathways
T40870	Leukotriene E4 LTE4	Endogenous Metabolite	Metabolism
	Leukotriene E4 (LTE4)（LTE4）通过二肽酶对LTD4 上的作用生成，是过敏性休克慢反应物质（SRS-A）的成分之一。LTE4 存在于血浆和尿液中，可用于检测哮喘。
T38062	N-acetyl Leukotriene E4 N-acetyl Leukotriene E4
	N-acetyl LTE4 is the major inactive metabolite of LTE4 found in bile. This route of metabolism is prominent in the rat, but of minor importance in humans. N-acetyl LTE4 is 100 times less potent than LTC4 as a vasoconstricting agent. In healthy human subjects urinary excretion of N-acetyl LTE4 is about 1.5 nmol/mol creatinine, which is considerably less than that of LTE4 (12 nmol/mol creatinine).
T37494	11-trans Leukotriene E4 11-trans Leukotriene E4
	Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.
T32680	Leukotriene E-4 sulfone
	Leukotriene E-4 sulfone is a synthetic leukotriene.
T37262	14,15-Leukotriene E4 14,15-Leukotriene E4
	Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. These metabolites are classified as eoxins because they are formed mostly by eosinophils...
T23390	SR 2640 hydrochloride	Leukotriene Receptor	GPCR/G Protein
	SR 2640 hydrochloride 是白三烯 D4 和 E4 的竞争性拮抗剂，可用于研究人类哮喘中的白三烯。
T2583	Cilastatin 西司他丁,MK0791	Proteasome; Antibacterial; Antibiotic	Microbiology/Virology; Proteases/Proteasome; Ubiquitination
	Cilastatin (MK0791) 是一种可逆的竞争性的肾脏脱氢肽酶 I 抑制剂，IC50为 0.1 μM。它抑制细菌金属叶内酰胺酶CphA 的IC50为 178 μM，可用作抗菌辅助剂。
T67959	Pirodomast	Thrombin; Serine Protease	Proteases/Proteasome
	Pirodomast 是血栓素 A（TXA2）合成酶抑制剂。Pirodomast 能抑制白三烯（LT）D4、C4、E4 的形成和血栓素 B2（TXB2）的活性，但对组胺、甲氧胆碱、血清素、LTC4 或血小板活化因子诱导的豚鼠支气管痉挛的拮抗作用较弱或无效。Pirodomast 在体外对豚鼠气管只有微弱的松弛活性。Pirodomast 是一种潜在的抗过敏化合物，在体外可抑制胰蛋白酶的蛋白水解活性，在体内可阻止抗原诱发过敏绵羊的即时和晚期哮喘反应，抑制抗原诱导的过敏绵羊对组胺和卡巴胆碱的气道高反应性。
T27893	LY 203647 LY203647,LY-203647
	LY 203647 is a antagonist of leukotriene D4 and E4 receptor.
T27904	LY 245769 LY-245769,LY245769
	LY 245769 is an inhibitor of leukotriene E4 (LTE4).