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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T9533	BC-LI-0186 4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide	Others	Others
	BC-LI-0186 (4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide) 是选择性抑制亮氨酸 tRNA 合成酶与 Ras 相关的 GTP 结合蛋白 D 相互作用(IC50=46.11 nM)。BC-LI-0186能有效抑制肿瘤相关 MTOR 突变体的特性和雷帕霉素耐药癌细胞的生长，能够用于肺癌的相关研究。
T4045	Epetraborole hydrochloride GSK2251052 hydrochloride	Antibacterial	Microbiology/Virology
	Epetraborole hydrochloride (GSK2251052 hydrochloride) 是一个新型 LeuRS 抑制剂，通过绑定 leucyl-tRNA 合成酶终端的腺苷核糖抑制蛋白合成，可研究 Gram-negative 细菌引起的感染。
T11497	Ganfeborole HCl GSK3036656 HCl,GSK656 HCl	Antibacterial	Microbiology/Virology
	Ganfeborole HCl (GSK3036656 HCl) 是一种具有抗结核活性的小分子化合物，是结核分枝杆菌（Mtb）亮氨酰-tRNA 合成酶（LeuRS；IC50：0.2 μM）的抑制剂。
T71168	Epetraborole R-Mandelate
	Epetraborole R-Mandelate is a potent and selective leucyl-tRNA synthetase inhibitor.
T71458	Epetraborole
	Epetraborole is a potent and selective leucyl-tRNA synthetase inhibitor. Epetraborole was in development for the treatment of infections caused by multidrug-resistant Gram-negative pathogens.
T11841	Leu-AMS R enantiomer	Others	Others
	Leu-AMS R enantiomer 是 Leu-AMS 的 R 对映体。 Leu-AMS 是一种有效的亮氨酰-tRNA 合成酶 (LRS) 抑制剂，可抑制细菌的生长。
T11840	Leu-AMS	Others	Others
	Leu-AMS, a leucine analogue and potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, exhibits cytotoxic effects in both cancer and normal cells and hampers bacterial growth. It specifically inhibits LRS's catalytic activity without impacting the leucine-induced activation of mTORC1.
T60405	GSK-3036656 free base GSK656 HCl,GSK 3036656,GSK656,GSK-3036656,GSK-656,GSK 656
	GSK656 (GSK3036656) 可有效抑制结核分枝杆菌 (Mtb) 亮氨酰-tRNA 合成酶 (LeuRS) (IC50 = 0.20 μM)，具有治疗结核病的潜力。
T39296	DS86760016
	DS86760016 is a highly effective inhibitor of leucyl-tRNA synthetase (LeuRS), demonstrating potent activity against multidrug-resistant (MDR) Gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Notably, DS86760016 effectively inhibits LeuRS enzymes derived from Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, exhibiting IC50 values of 0.38 μM, 0.62 μM, and 0.16 μM, respectively.
T38773	LeuRS-IN-1 hydrochloride
	LeuRS-IN-1 hydrochloride is a potent and orally active inhibitor of M. tuberculosis leucyl-tRNA synthetase (M.tb LeuRS). It has IC 50 and Kd values of 0.06 μM and 0.075 μM, respectively, for M.tb LeuRS. Additionally, LeuRS-IN-1 hydrochloride inhibits human cytoplasmic LeuRS with an IC 50 of 38.8 μM and HepG2 protein synthesis with an EC 50 of 19.6 μM.
T38775	LeuRS-IN-1
	LeuRS-IN-1 is a highly potent and orally active inhibitor of the leucyl-tRNA synthetase enzyme derived from Mycobacterium tuberculosis (M.tb LeuRS). It exhibits significant inhibitory activity against M.tb LeuRS with IC 50 and Kd values of 0.06 μM and 0.075 μM, respectively. Additionally, LeuRS-IN-1 effectively inhibits human cytoplasmic LeuRS with an IC 50 value of 38.8 μM and suppresses protein synthesis in HepG2 cells with an EC 50 value of 19.6 μM.

化合物

BC-LI-0186

Cat.No: T9533

Synonym: 4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide

Target: Others

Epetraborole hydrochloride

Cat.No: T4045

Synonym: GSK2251052 hydrochloride

Target: Antibacterial

Ganfeborole HCl

Cat.No: T11497

Synonym: GSK3036656 HCl,GSK656 HCl

Target: Antibacterial

Epetraborole R-Mandelate

GSK-3036656 free base

Cat.No: T60405

Synonym: GSK656 HCl,GSK 3036656,GSK656,GSK-3036656,GSK-656,GSK 656

LeuRS-IN-1 hydrochloride

Cat. No.	Product Name	Target	Signaling Pathways
TL0005	3,5-O-Dicaffeoylquinic acid Isochlorogenic Acid A,(-)-3,5-二咖啡酰奎宁酸,(-)-3,5-Dicaffeoyl quinic acid,3,5-Dicaffeoylquinic Acid	Others	Others
	3,5-O-Dicaffeoylquinic acid (Isochlorogenic Acid A) 能够改善由三甲基锡诱导的学习和记忆缺陷。

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3,5-O-Dicaffeoylquinic acid

Cat.No: TL0005

Synonym: Isochlorogenic Acid A,(-)-3,5-二咖啡酰奎宁酸,(-)-3,5-Dicaffeoyl quinic acid,3,5-Dicaffeoylquinic Acid

Target: Others

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