Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Leu-AMS, a leucine analogue and potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, exhibits cytotoxic effects in both cancer and normal cells and hampers bacterial growth. It specifically inhibits LRS's catalytic activity without impacting the leucine-induced activation of mTORC1.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | Leu-AMS, a leucine analogue and potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, exhibits cytotoxic effects in both cancer and normal cells and hampers bacterial growth. It specifically inhibits LRS's catalytic activity without impacting the leucine-induced activation of mTORC1. |
靶点活性 | LRS:22.34 nM |
体外活性 | Leu-AMS does not affect S6 kinase (S6K) phosphorylation at all.?Leu-AMS inhibits the catalytic activity of LRS but does not affect the leucine-induced mTORC1 activation[1].Leu-AMS is proved to be a potent inhibitor of Leucyl-tRNA Synthetase (LRS) with an IC50 value of 22.34 nM.?Leu-AMS is highly cytotoxic in both cancer cells and normal cells. |
分子量 | 459.48 |
分子式 | C16H25N7O7S |
CAS No. | 288591-93-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 49.17 mg/mL (107.01 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1764 mL | 10.8819 mL | 21.7637 mL | 54.4093 mL |
5 mM | 0.4353 mL | 2.1764 mL | 4.3527 mL | 10.8819 mL | |
10 mM | 0.2176 mL | 1.0882 mL | 2.1764 mL | 5.4409 mL | |
20 mM | 0.1088 mL | 0.5441 mL | 1.0882 mL | 2.7205 mL | |
50 mM | 0.0435 mL | 0.2176 mL | 0.4353 mL | 1.0882 mL | |
100 mM | 0.0218 mL | 0.1088 mL | 0.2176 mL | 0.5441 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Leu-AMS 288591-93-5 Others Leu AMS LeuAMS Inhibitor inhibitor inhibit