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抑制剂 & 化合物

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天然产物

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Cat. No. Product Name Target Signaling Pathways
T5093 Pim1/AKK1-IN-1

LKB1/AAK1 dual inhibitor,MDK-2275

Pim; Hippo pathway Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) 是多种酶抑制剂,能够作用于Pim1、AKK1、MST2 和 LKB1,Kd 值分别为 35、53、75 和 380 nM,还抑制 MPSK1 和 TNIK。
T13173 TMPA

Others; AMPK Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
TMPA 是一种核受体 Nur77 和 LKB1 相互作用的拮抗剂。

化合物

Pim1/AKK1-IN-1
Cat.No: T5093
Synonym: LKB1/AAK1 dual inhibitor,MDK-2275
Target: Pim, Hippo pathway
TMPA
Cat.No: T13173
Synonym:
Target: Others, AMPK
Cat. No. Product Name Target Signaling Pathways
T3904 Gomisin J

Calcium Channel; AMPK Chromatin/Epigenetic; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
Gomisin J 是在五味子中发现的小分子量木脂素,具有血管舒张活性,在非酒精性脂肪性肝病方面有研究潜力。 它通过激活 AMPK、LKB1 和 Ca2+/钙调蛋白依赖性蛋白激酶 II 以及抑制 HepG2 细胞中的胎球蛋白 A 来调节脂肪生成酶和脂肪分解酶以及炎症分子的表达,从而抑制脂质积累。
T2854 Phillyrin

Forsythin,连翘苷

P450; Influenza Virus; AMPK Chromatin/Epigenetic; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling
Phillyrin (Forsythin) 是从连翘中分离出来的一种天然产物,具有抗甲型流感病毒的活性,以及抗菌和消炎作用。
T35624 Ajoene

Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

Gomisin J
Cat.No: T3904
Synonym:
Target: Calcium Channel, AMPK
Phillyrin
Cat.No: T2854
Synonym: Forsythin,连翘苷
Target: P450, Influenza Virus, AMPK
Ajoene
Cat.No: T35624
Synonym:
Target:
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