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Cat. No. Product Name Target Signaling Pathways
T37807 JTV 519 fumarate

Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo. Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J. 404 431 PMID:17313373 |Chen et al (2008) Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol. 153 915 PMID:17994112 |...
T24239 K201

K-201,JTV 519,JTV-519,K 201

Calcium Channel Membrane transporter/Ion channel; Metabolism
K201 (JTV-519) 是一种 Ca2+ 依赖性阻滞剂,通过稳定兰尼碱受体来防止缺血性心脏和骨骼肌 (SkM) 中的肌质网异常 Ca(2+) 泄漏。
T11732 JTV-519 hemifumarate

K201 hemifumarate

MELK PI3K/Akt/mTOR signaling
JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle.
T11731 JTV-519 free base

K201 free base

FLT Angiogenesis; Tyrosine Kinase/Adaptors
JTV-519 free base (K201 free base), recognized for its antiarrhythmic and cardioprotective properties, functions as a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and serves as a partial agonist of ryanodine receptors in striated muscle.
T11731L JTV-519 Formate

JTV-519 Formate (145903-06-6 Free base)

Others; Calcium Channel Membrane transporter/Ion channel; Metabolism; Others
JTV-519 Formate 是一种 Ca2+ 依赖性的肌质网 Ca2+ 刺激的 ATP 酶 (SERCA) 阻断剂,同时也是横纹肌中兰尼碱受体 (ryanodine receptors) 的部分激动剂。JTV-519 Formate 显示出抗心律失常作用,是一种心脏保护剂。

化合物

JTV 519 fumarate
Cat.No: T37807
Synonym:
Target:
K201
Cat.No: T24239
Synonym: K-201,JTV 519,JTV-519,K 201
Target: Calcium Channel
JTV-519 hemifumarate
Cat.No: T11732
Synonym: K201 hemifumarate
Target: MELK
JTV-519 free base
Cat.No: T11731
Synonym: K201 free base
Target: FLT
JTV-519 Formate
Cat.No: T11731L
Synonym: JTV-519 Formate (145903-06-6 Free base)
Target: Others, Calcium Channel
TargetMol Loading
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