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Cat. No.	Product Name	Target	Signaling Pathways
T17311	(+)-JQ1 PA	Epigenetic Reader Domain	Chromatin/Epigenetic
	(+)-JQ1 PA 是一种溴结构域和末端外 (BET) 抑制剂 JQ1 的衍生物，IC50 为 10.4 nM。
T10526	β-NF-JQ1	Others	Others
	β-NF-JQ1是一种PROTAC，可将芳烃受体E3 （AhR E3）连接酶招募到目标蛋白上。β-NF-JQ1使用β-NF 作为AhR 配体靶向含溴odomain（BRD）的蛋白，诱导AhR 和BRD 蛋白相互作用。β-NF-JQ1显示出与蛋白敲除活性相关的强大的抗癌活性。
T19618	(R)-(-)-JQ1 Enantiomer (R)-(-)2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂环庚烷-6-基)乙酸叔丁酯	Epigenetic Reader Domain	Chromatin/Epigenetic
	(R)-(-)-JQ1 Enantiomer 是 (+)-JQ1 的立体异构体。 (+)-JQ1 是一种 BET 溴结构域抑制剂，对BRD4(1/2)的IC50 为 77 和 33 nM。
T2110	(+)-JQ-1 JQ1	Epigenetic Reader Domain; Autophagy; Ligands for Target Protein for PROTAC	Autophagy; Chromatin/Epigenetic; PROTAC
	(+)-JQ-1 (JQ1) 是一种 BET 溴结构域抑制剂，抑制 BRD4(1/2) (IC50=77/33 nM)，具有特异性和可逆性。(+)-JQ-1 可以诱导细胞自噬，抑制细胞增殖。
T18060	KB02-JQ1	Others	Others
	KB02-JQ1 is a potent and specific proteolysis targeting chimera (PROTAC) that specifically degrades BRD4, acting as a molecular glue. It does not degrade BRD2 or BRD3. The mechanism of action involves covalent modification of the E3 ligase DCAF16, thereby promoting BRD4 degradation. Importantly, KB02-JQ1 demonstrates enhanced stability and durability in facilitating protein degradation within biological systems. The compound forms a complex with the ubiquitin E3 ligase ligand KB02 through a link...
T70702	JQ1-Acid HCl
	(+)-JQ-1 carboxylic acid is a potent bromodomain and extra terminal domain (BET) inhibitor. (+)-JQ-1 carboxylic has potential to be used as a precursor to synthesize PROTACs and other conjugates.
T81675	NICE-01 AP1867-PEG2-JQ1,AP-PEG2-JQ1
	NICE-01 (AP1867-PEG2-JQ1; AP-PEG2-JQ1)是一款具有双功能的化合物，它通过特异性结合到细胞内特定亚细胞区室中的蛋白质，并以BRD4蛋白的核定位含溴结构域作为诱导，实现将胞浆中的货物输送至细胞核。
T83929	(+)-JQ1 maleimide
	(+)-JQ1 maleimide是一种探针，由一个与BRD4配体JQ1通过PEG2连接器相连的含有活性的maleimide组成。它可用于COFFEE方法（COvalent Functionalization Followed by E3 Electroporation），在该方法中，(+)-JQ1 maleimide与VHL共价连接后通过电穿孔导入活细胞。E3连接酶在细胞内与BRD4形成复合物，引导其降解。
T74753	JQ1-TCO
	JQ1-TCO (JQ1-trans-cycloctene) 是一种 BET 抑制剂 JQ1 的衍生物。JQ1-TCO 适用于点击化学，可作为体外和体内的分子探针。
T83931	JQ1-FITC
	JQ1-FITC是一种荧光BET溴结构域探针。它与BRD4(BD1)和BRD4(BD2)具有高亲和力绑定（KD,app值分别为6.5 nM和5.8 nM，使用GST标签的BRD4蛋白，通过CoraFluorTR-FRET实验测定；在荧光偏振实验中，对于BRD4(BD1)的值为58.7 nM）。激发和发射峰（λ）分别为495 nm和525 nm。
T74428	Biotinylated-JQ1
	Biotinylated-JQ1 (Biotin-JQ1)为JQ1的一种生物素化衍生物，具有高亲和力地结合至BRD4溴域的能力。该化合物能有效抑制MM1.S多发性骨髓瘤细胞的增殖，其EC50值为0.4 μM。
T5443	JQ-1 (carboxylic acid) JQ-1 carboxylic acid	Epigenetic Reader Domain	Chromatin/Epigenetic
	JQ-1 (carboxylic acid) 是一种细胞渗透性 BRD4 抑制剂，对 BRD4(1) 和 BRD4(2) 的 IC50 分别为 77 和 33 nM。它是一种 (+)-JQ1 衍生物，可作为合成 PROTACs 的前体。
T62357	ET-JQ1-OH
	ET-JQ1-OH 是一种等位基因特异性的 BET 抑制剂。
T70700	Calanolide B
	Calanolide B is one of a novel class of HIV-inhibiting coumarins from the tropical rainforest tree, Calophyllum lanigerum.
T4495	dBET1	Epigenetic Reader Domain	Chromatin/Epigenetic
	dBET1 是一种由 BRD4 抑制剂 JQ1 与 NSC 527179 衍生物通过 linker 产生的 PROTAC，可诱导 BRD4 降解。它是由Cereblon 配体和BRD4配体相连的PROTAC，其EC50值为 430 nM。
T12513	PNZ5	Epigenetic Reader Domain	Chromatin/Epigenetic
	PNZ5 是一个有效的、异恶唑类的、BET 的广泛抑制剂，有着类似(+)-JQ1 的高选择性和强效作用，其对 BRD4(1) 的 KD 值为 5.43 nM。
T4247	I-CBP112 hydrochloride	Epigenetic Reader Domain	Chromatin/Epigenetic
	I-CBP112 hydrochloride 是含溴结构域转录因子的选择性抑制剂，靶向 CBP/p300 溴结构域。在体内外，它以剂量依赖性方式显着降低 MLL-AF9(+) 急性髓细胞白血病细胞的白血病起始潜力，还增加 BET 溴结构域抑制剂 JQ1 以及阿霉素的细胞毒活性。
T16312	NH2-PEG3 PROTAC Linker 35	Others	Others
	NH2-PEG3 (PROTAC Linker 35) is a polyethylene glycol (PEG) linker utilized in the synthesis of PROTAC (β-NF-JQ1)[1].
T13981	β-Naphthoflavone-CH2-Br β-NF-CH2-Br	Others	Others
	β-Naphthoflavone-CH2-Br is an arylhydrocarbon receptor (AhR) ligand. β-Naphthoflavone-CH2-Br used to synthesize the PROTAC β-NF-JQ1.
T18600	VH032 thiol VHL ligand 6	Others	Others
	VH032 thiol (VHL ligand 6) is a VHL ligand that interacts with pan-BET inhibitor JQ1 through a linker to create a PROTAC[1] compound.
T35412	(+)-JQ-1-aldehyde
	(+)-JQ-1-aldehyde is the aldehyde derivative of (+)-JQ1, commonly used as a precursor for the synthesis of PROTACs targeting the BET bromine domain[1].
T75170	BI01826025
	BI01826025 (pArg-JQ1) 是BRDTbromodomain1 (BRDTBD1)PROTAC 降解剂。BI01826025 可用于检测 ClpC2 对 ClpC1P1P2 蛋白酶的调控作用。
T75169	SRG-II-19F
	SRG-II-19F (dCym-JQ1) 是 BRDTbromodomain1 (BRDTBD1) 降解剂。SRG-II-19F 可用于检测 ClpC2 对 ClpC1P1P2 蛋白酶的调控作用。
T13105	TD-428	Epigenetic Reader Domain	Chromatin/Epigenetic
	TD-428 is a highly specific degrader of BRD4(DC50 of 0.32 nM). TD-428 is a BET PROTAC, which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD-428 efficiently induce BET protein degradation.
T70593	GW-841819X
	GW841819X is an analogue of (+)-JQ1 and a novel inhibitor of BET bromodomains. GW841819X displayed activity in vivo against NUT-midline carcinoma, multiple myeloma, mixed-lineage leukemia, and acute myeloid leukemia. Bromodomain and extra-terminal (BET) proteins belong to a class of proteins collectively called epigenetic readers". BET bromodomains have emerged as promising drug targets for treatment of cancers
T17363	β-Naphthoflavone-CH2-OH β-NF-CH2-OH	Others	Others
	β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) serves as an AhR E3 ligase ligand, forming chimeric molecules when connected to a protein ligand through a linker, resulting in PROTACs or SNIPERs (e.g., β-naphthoflavone-JQ1). These chimeric molecules recruit the AhR E3 ligase complex by incorporating AhR ligands. By inducing ubiquitination-mediated degradation, PROTACs effectively target and degrade cancer-promoting proteins [1].
T36574	GW841819X GW841819X
	GW841819X is an analogue of (+)-JQ1 and a novel inhibitor of BET bromodomains. GW841819X was a single enantiomer but of undefined chirality at the 4-position of the benzodiazepine ring3. GW841819X and JQ1 were recently discovered that bind to the acetyl-lysine binding pocket of BET bromodomains with Kd ranges from 50 to 370 nM [1]. GW841819X bounded to both the individual BD1 and BD2 domains with affinities of 46 and 52.5 nM, respectively. GW841819X-Brd3 interaction was estimated to be around 70...
T41198	BRD PHOTAC-I-3
	BRD PHOTAC-I-3 is a photoswitchable BET bromodomain degrader (PHOTAC, PHOtochemically TArgeting Chimera). BRD PHOTAC-I-3 comprises a ligand for an E3 ligase, a photoswitch, and the BET bromodomain targeting ligand (+)-JQ1. Exhibits cytotoxicity and degrades BRD4, BRD3 and to a lesser extent BRD2 in lymphoblast cells upon irradiation with 390 nm light, but not in the dark.
T39923	KB02-COOH KB02-COOH
	KB02-COOH is a synthetic fragment derived from ubiquitin E3 ligase ligand KB02, which possesses potential utility in the synthesis of PROTAC compounds. Notably, KB02-COOH can be employed in the generation of PROTAC constructs like KB02-JQ1 and KB02-SLF.
T36800	EN219
	EN219 is a synthetic recruiter of the E3 ubiquitin ligase RNF114.1It binds to cysteine 8 (C8) in the intrinsically disordered region of RNF114 (RNF114-C8; IC50= 470 nM) and inhibits RNF114-induced autoubiquitination and p21 ubiquitination in a cell-free assay when used at a concentration of 50 μM. EN219 (1 μM) also interacts with cysteine residues in the tubulin β1 chain (TUBB1), heat shock protein 60 (Hsp60), also known as Hsp family D member 1 (HspD1), and histone H3.1 (HIST1H3A) in 231MFP hum...

化合物

Cat.No: T17311

Target: Epigenetic Reader Domain

Cat.No: T10526

Target: Others

(R)-(-)-JQ1 Enantiomer

Cat.No: T19618

Synonym: (R)-(-)2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂环庚烷-6-基)乙酸叔丁酯

Target: Epigenetic Reader Domain

Cat.No: T2110

Synonym: JQ1

Target: Epigenetic Reader Domain, Autophagy, Ligands for Target Protein for PROTAC

Cat.No: T18060

Target: Others

Cat.No: T70702

Cat.No: T81675

Synonym: AP1867-PEG2-JQ1,AP-PEG2-JQ1

(+)-JQ1 maleimide

Cat.No: T83929

Cat.No: T74753

Cat.No: T83931

Biotinylated-JQ1

Cat.No: T74428

JQ-1 (carboxylic acid)

Cat.No: T5443

Synonym: JQ-1 carboxylic acid

Target: Epigenetic Reader Domain

Cat.No: T62357

Cat.No: T70700

Cat.No: T4495

Target: Epigenetic Reader Domain

Cat.No: T12513

Target: Epigenetic Reader Domain

I-CBP112 hydrochloride

Cat.No: T4247

Target: Epigenetic Reader Domain

Cat.No: T16312

Synonym: PROTAC Linker 35

Target: Others

β-Naphthoflavone-CH2-Br

Cat.No: T13981

Synonym: β-NF-CH2-Br

Target: Others

Cat.No: T18600

Synonym: VHL ligand 6

Target: Others

(+)-JQ-1-aldehyde

Cat.No: T35412

Cat.No: T75170

Cat.No: T75169

Cat.No: T13105

Target: Epigenetic Reader Domain

Cat.No: T70593

β-Naphthoflavone-CH2-OH

Cat.No: T17363

Synonym: β-NF-CH2-OH

Target: Others

Cat.No: T36574

Synonym: GW841819X

Cat.No: T41198

Cat.No: T39923

Synonym: KB02-COOH

Cat.No: T36800

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