Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T79079 |
JAK1-IN-11
|
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
JAK1-IN-11(compound 11)是一种针对JAK1和JAK2具有显著抑制效果的化合物,其中对JAK1的IC50为0.02 nM,对JAK2的IC50为0.44 nM,表现出对JAK1较高的选择性。 | |||
T1849 |
Momelotinib
CYT11387,CYT387,LM-1149 |
Apoptosis; JAK; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Momelotinib (LM-1149) 是一种 ATP 竞争性的 JAK1/JAK2抑制剂,IC50值分别为 11 nM/18 nM。 | |||
T2636 |
Decernotinib
VX-509,VRT-831509 |
Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Decernotinib (VRT-831509) 是一种可口服的JAK3抑制剂,对JAK3、JAK1、JAK2 和 TYK2 的Ki 值分别为 2.5、11、13 和 11 nM。 | |||
T61658 |
TYK2-IN-11
|
||
TYK2-IN-11 (Compound 5B) is a potent and selective inhibitor of Tyk-2, providing inhibition to TYK2-JH2 and JAK1-JH2 with IC50 values of 0.016 nM and 0.31 nM, respectively. This compound demonstrates potential for advancing research in the area of inflammatory and autoimmune diseases [1]. |