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Cat. No.	Product Name	Target	Signaling Pathways
T6252	Ipatasertib GDC-0068,RG7440,帕他色替	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Ipatasertib (GDC-0068) 是选择性的，ATP 竞争性的pan-Akt 抑制剂，能够抑制Akt1 (IC50:5 nM)，Akt2 (IC50:18 nM)，Akt3 (IC50:8 nM)。
T15374	Ipatasertib dihydrochloride GDC-0068 dihydrochloride,RG-7440 dihydrochloride	Akt; PKA	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) 是ATP 竞争性的pan-Akt 选择性抑制剂，抑制Akt1，Akt2，Akt3，IC50分别为 5，18，8 nM。
T38393	Ipatasertib-NH2 dihydrochloride RG7440-NH2 dihydrochloride,Ipatasertib-NH2 dihydrochloride,GDC-0068-NH2 dihydrochloride
	Ipatasertib-NH2 dihydrochloride is a ligand for the target protein AKT in PROTAC INY-03-041. INY-03-041 consists of Ipatasertib-NH2, a ten-hydrocarbon linker, and the CRBN ligand Lenalidomide, which acts as an E3 ubiquitin ligase.
T70552	Ipatasertib tosylate
	Ipatasertib, also known as GDC0068, is an orally active, potent and selective Akt inhibitor. GDC-0068 blocked Akt signaling both in cultured human cancer cell lines and in tumor xenograft models. Inhibition of Akt activity by GDC-0068 resulted in blockade of cell-cycle progression and reduced viability of cancer cell lines. Markers of Akt activation, including high-basal phospho-Akt levels, PTEN loss, and PIK3CA kinase domain mutations, correlate with sensitivity to GDC-0068. In multiple tumor...
T18053	Ipatasertib-NH2 RG7440-NH2,GDC-0068-NH2	Others	Others
	Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 to degrade AKT[1].
T27621	Ipatasertib HCl GDC0068,RG 7440,GDC 0068,RG-7440,GDC-0068,RG7440
	Ipatasertib is an orally active, potent and selective Akt inhibitor with antitumor activity. Inhibition of Akt activity by Ipatasertib resulted in blockade of cell-cycle progression and reduced viability of cancer cell lines. Markers of Akt activation, in
T70550	BMS-986034
	BMS-986034 is a GPR119 agonist.
T74001	INY-03-041 trihydrochloride
	INY-03-041 trihydrochloride 是一种有效的、高选择性的、基于PROTAC 的泛-AKT 降解剂，由ATP 竞争性AKT 抑制剂Ipatasertib 结合Lenalidomide 组成。INY-03-041 trihydrochloride 可抑制AKT1，AKT2和AKT3，IC50分别为 2.0 nM，6.8 nM 和 3.5 nM。