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Cat. No.	Product Name	Target	Signaling Pathways
T8741	MitoBloCK-10 3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m	Others	Others
	MitoBloCK-10 (3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m) 是第一个能够减弱PAM 复合体活性的小分子调节剂，对 C 末端结构域的Tim44与前体和 Hsp70 结合具有抑制作用。
T7535	RGX-202 胍基丙酸,β-GPA,3-Guanidinopropionic Acid	AMPK; PPAR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
	RGX-202 (β-GPA) 是口服有活性的SLC6A8转运蛋白抑制剂。它在体内外均能够强烈地抑制肌酸输入，降低细胞内磷酸肌酸和 ATP 水平，诱导肿瘤凋亡，可于研究肿瘤。
T3445	Importazole	Apoptosis; Others	Apoptosis; Others
	Importazole 是一种核转运受体 importin-β 小分子抑制剂。
T3445L	Importazole HCl (662163-81-7 free base) Importazole hydrochloride,Importazole HCl,Importazole
	Importazole specifically inhibits the importin-β likely by altering its interaction with RanGTP.
T27612	INI-43 INI 43,INI43	Others	Others
	INI-43 是Nuclear Import-43 的抑制剂，通过靶向 Kpnβ1 对各种宫颈和食管癌细胞系显示出显着的细胞毒性作用，并干扰 Kpnβ1 和已知的 Kpnβ1 cargo 蛋白、NFAT、NFκB、AP-1和NFY 的核定位。
T8782	MitoBloCK-11 (MB-11)	Others	Others
	MitoBloCK-11 (MB-11) 是线粒体蛋白输入的小分子抑制剂，可能通过转运蛋白 Seo1 起作用，但不通过 Tom70 或 Tom20；抑制含有疏水片段的前体蛋白，以特定方式在缺乏尿嘧啶的培养基中促进生长，并影响斑马鱼的发育。
T60165	VB124	Monocarboxylate transporter	Membrane transporter/Ion channel
	VB124 是一种具有口服活性的、有效且选择性的MCT4抑制剂。VB124 可特异性抑制 MDA-MB-231 细胞中乳酸的涌入和流出，IC50分别为 8.6 nM 和 19 nM。VB124 对 MCT4 的选择性高于 MCT1。VB124可用于心脏肥大、心力衰竭和代谢的研究。
T81675	NICE-01 AP1867-PEG2-JQ1,AP-PEG2-JQ1
	NICE-01 (AP1867-PEG2-JQ1; AP-PEG2-JQ1)是一款具有双功能的化合物，它通过特异性结合到细胞内特定亚细胞区室中的蛋白质，并以BRD4蛋白的核定位含溴结构域作为诱导，实现将胞浆中的货物输送至细胞核。
T38153	NF-κB Inhibitor (trifluoroacetate salt)
	NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.1It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.1In this way, NF-κB inhibitor blocks gene expression that is regulated by NF-κB.2,3This peptide is commonly used to evaluate the role of NF-κB signaling in cellular responses.4,5
T37559	NF-κB Control
	NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells. It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α. NF-κB control is a peptide that is identical in sequence to NF-κB inhibitor, except two essential, basic residues of the p105 NLS are substituted with non-basic amino acids...
TP1830	SV40 large T antigen NLS
	SV40 large T antigen NLS is from Large T antigen residue 47 to 55, enables protein import into cell nucleus. This peptide is generated from Large T antigen residue 47 to 55.
T76419	Protein Kinase C γ Peptide
	Protein Kinase C γ Peptide，Protein Kinase Cγ 的肽片段，为显性共济失调的致病蛋白，能够负向调节隐性共济失调相关失联蛋白的核输入。
TP1830L	SV40 large T antigen NLS acetate	Others	Others
	SV40 large T antigen NLS acetate 是从大 T 抗原残基 47 到 55，使蛋白质进入细胞核。
T24692	QAQ dichloride
	QAQ dichloride is a photoswitchable compound that blocks voltage-gated Na v and K v channels. Its channel-blocking activity is observed in the trans form of the azobenzene photoswitch, while the cis form does not exhibit this effect. This compound is membrane-impermeant and selectively enters pain-sensing neurons expressing endogenous import channels. QAQ dichloride functions as a light-sensitive analgesic and provides a valuable tool for investigating signaling mechanisms involved in acute and ...
T60511	Theophylline sodium glycinate
	Theophylline (1,3-Dimethylxanthine) sodium glycinate 是一种有效的磷酸二酯酶 (PDE) 抑制剂，可抑制 PDE3 活性以松弛气道平滑肌。Theophylline sodium glycinate 可用于研究哮喘和慢性阻塞性肺疾病 (COPD) 。Theophylline sodium glycinate 也是一种腺苷受体拮抗剂和组蛋白脱乙酰酶 (HDAC) 激活剂。 Theophylline sodium glycinate 通过增加 IL-10 和抑制 NF-κB 的核输入而具有抗炎活性。Theophyllin sodium glycinate 可诱导细胞凋亡。

化合物

Cat.No: T8741

Synonym: 3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m

Target: Others

Cat.No: T7535

Synonym: 胍基丙酸,β-GPA,3-Guanidinopropionic Acid

Target: AMPK, PPAR

Cat.No: T3445

Target: Apoptosis, Others

Importazole HCl (662163-81-7 free base)

Cat.No: T3445L

Synonym: Importazole hydrochloride,Importazole HCl,Importazole

Cat.No: T27612

Synonym: INI 43,INI43

Target: Others

MitoBloCK-11 (MB-11)

Cat.No: T8782

Target: Others

Cat.No: T60165

Target: Monocarboxylate transporter

Cat.No: T81675

Synonym: AP1867-PEG2-JQ1,AP-PEG2-JQ1

NF-κB Inhibitor (trifluoroacetate salt)

Cat.No: T38153

Cat.No: T37559

SV40 large T antigen NLS

Cat.No: TP1830

Protein Kinase C γ Peptide

Cat.No: T76419

SV40 large T antigen NLS acetate

Cat.No: TP1830L

Target: Others

Cat.No: T24692

Theophylline sodium glycinate

Cat.No: T60511

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