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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T78264	Anti-Mouse IL-1b Antibody (B122)
	Anti-Mouse IL-1b Antibody为针对小鼠IL-1b的IgG类抗体抑制剂，其宿主为Armenian Hamster。
T62959	LRH-1 modulator-1
	LRH-1 modulator-1 是一种有效的 LRH-1 (肝受体同源物 -1) 调节剂/激动剂。LRH-1 modulator-1 能够诱导抗炎细胞因子 IL-10，对炎症细胞因子 IL-1b 和 TNFa 表现出抑制作用。LRH-1 modulator-1 在肠道类器官中具有抗炎活性。
T38159	STING Agonist 12b
	STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 μM, respectively). STING agonist 12b (40 μM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells. 1.Hou, S., Lan, X.-j., Li, W., et al.Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonistsBioorg. Chem.95103556(2020)
T75812	MMK1 TFA
	MMK1 TFA 是一种有效的选择性人甲酰肽受体样 1 (FPRL-1/FPR2) 激动剂，对 FPRL-1 和 FPR1 的 EC50值分别为 <2 nM 和 >10000 nM。MMK1 TFA 是一种有效的趋化剂和钙动员 (calcium-mobilizing) 激动剂。MMK1 TFA 可有效激活吞噬性白细胞，并可增强人单核细胞对百日咳毒素敏感的促炎细胞因子 IL-1b 和IL-6的产生。MMK1 TFA 发挥抗焦虑样活性。
T68225	Fc 11a-2
	Fc 11a-2 是一种苯并咪唑化合物，一种具有口服活性且有效的NLRP3炎症小体 (NLRP3inflammasome) 抑制剂。Fc 11a-2 通过抑制caspase-1的激活进而抑制 IL-1b/IL-18 的激活来抑制NLRP3炎性体的形成。Fc 11a-2 可防止Dextran sulfate sodium(DSS) 诱导的小鼠实验性结肠炎。

化合物

Anti-Mouse IL-1b Antibody (B122)

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02134	IL-1 beta/IL-1F2 Protein, Mouse, Recombinant Il-1b,IL-1beta,白细胞介素,int...	Mouse	E. coli
	IL-1 beta/IL-1F2 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P10749.
TMPY-01999	IL-1 beta/IL-1F2 Protein, Human, Recombinant (His) IL-1,IL1-β,白介素,IL1-BETA,白细胞介素,	Human	E. coli
	IL-1 beta/IL-1F2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 32.3 kDa and the accession number is P01584.
TMPY-01049	IL-1 beta/IL-1F2 Protein, Human, Recombinant IL-1 beta,interleukin 1, beta,IL-1B	Human	E. coli
	IL-1 beta/IL-1F2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17 kDa and the accession number is P01584.
TMPK-00515	IL-1 beta/IL-1F2 Protein, Cynomolgus, Recombinant (His) Interleukin-1 β,IL-1 beta,IL1B,	Cynomolgus	E. coli
	Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta/IL-1F2 Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with C-His tag. The p...
TMPK-00162	IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi), Biotinylated IL-1 β,IL-1β,IL-1 β/IL-1...	Human	E. coli
	Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with C...
TMPK-00161	IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi) Interleukin-1 beta,IL-1 β,IL-1β,IL	Human	E. coli
	Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi) is expressed in E. coli expression system with C-His-Avi tag. ...
TMPK-01414	Qa-1b&B2M&Qdm (AMAPRTLLL) Monomer Protein, Mouse, MHC (His & Avi) Qa-1b,Qdm,MHC,H2-T23	Mouse	HEK293 Cells
	Qa-1b binds a peptide (AMAPRTLLL), referred to as Qdm (for Qa-1 determinant modifier), derived from the signal sequence of murine class Ia molecules. This peptide binds with high affinity and accounts for almost all of the peptides associated with this molecule. Human histocompatibility leukocyte antigen (HLA)-E, a homologue of Qa-1b, binds similar peptides derived from human class Ia molecules and interacts with CD94/NKG2 receptors on natural killer cells.