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31

抑制剂 & 化合物

9

天然产物

12

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T20913 Light Green SF Yellowish

Acid Green 5,C.I. Acid Green 5,C.I. 42095

Light Green SF Yellowish (Acid Green 5) 是一种碱性染色剂,可用于动物组织染色,可用于植物组织学中作细胞质和纤维染色。
T61416 Antileishmanial agent-9

Antileishmanial agent-9 (compound 16c) exhibits potent and selective activity against Leishmania donovani (L. donovani) with an IC50 value of 4.01 μM. In addition, this compound demonstrates relatively low cytotoxicity in L-6 cells, with an IC50 value of 40.1 μM [1].
T78963 Antileishmanial agent-16

Parasite Microbiology/Virology
Antileishmanial agent-16 (化合物 14c) 是一种针对Leishmania的抗原虫剂,表现出针对Leishmaniamajor前鞭毛体的高效活性(IC50=0.59 µM)以及对Leishmaniamajor无鞭毛体的有效活性(IC50=0.81 µM)。此外,Antileishmanial agent-16对哺乳动物细胞(VERO 细胞)的毒性低,说明其具有较好的安全性。
T79419 Antileishmanial agent-24

Parasite Microbiology/Virology
Antileishmanial agent-24 (compound 33) Exhibiting an IC50 of 5.39 μM against the amastigote form.
T40117 Antileishmanial agent-1

Antileishmanial agent-1 demonstrates activity against both L. amazonensis promastigotes (IC 50 = 15.52 μM) and intracellular amastigotes (IC 50 = 4.10 μM).
T123912 Rishirilide B

T62210 Antileishmanial agent-10

Antileishmanial agent-10 (Compound 7h) 是一种抗原虫 (antiprotozoal) 剂。
T61100 Antileishmanial agent-4

Antileishmanial agent-4 是一种核糖核苷类似物,作为抗黑热病试剂。
T78459 Leishman's stain

Leishman's stain为外周血和骨髓涂片染色的关键试剂,染色结果呈淡蓝灰色至深蓝色(在油镜下观察)。
T79471 Antileishmanial agent-20

Parasite Microbiology/Virology
Antileishmanial agent-20 显示对利什曼原虫的选择性抑制作用,其针对L. infantum和L. braziliensis的IC50值分别为2.8 μM 和0.2 μM,适用于寄生虫研究领域。
T25158 Bishomoreserpine

Reserpic acid

Bishomoreserpine is a reserpine analog with a potent inhibitory.
T123869 Parishin G

Parishin G 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T123869。
T63281 Antileishmanial agent-11

Antileishmanial agent-11 是有效的抗利什曼原虫剂,能够作用于 Leishmania brazilensis (IC50: 28.3 μM)、Leishmania infantum (IC50: 24.8 μM) 和T. cruzi(IC50: 13.0 μM) 具有出抗原虫作用。
T61710 Antileishmanial agent-7

Antileishmanial agent-7 (compound 23) exhibits strong antileishmanial activity against Leishmania donovani and L-6, with IC50 values of 6.89 and 259 μM, respectively [1].
T83679 Parasin I (catfish) TFA

Parasin I是来自鲶鱼(P. asotus)组蛋白H2A N端区域的一种抗微生物肽片段,参与宿主防御。它通过在受伤P. asotus的皮肤黏膜中的cathepsin D从组蛋白H2A形成。Parasin I对多种革兰氏阳性和阴性细菌以及真菌具有活性(MICs分别为1-2, 1-4, 和1-2 µg/ml)。
T79390 Antileishmanial agent-23

Parasite Microbiology/Virology
Antileishmanial agent-23 (compound G1/9) 作为一种选择性trypanothione reductase (TR)抑制剂效力显著,展现了2.24 ± 0.52 μM的IC50值。该化合物有效抑制了利什曼原虫、克氏锥虫和布氏锥虫的生长。
T61391 Antileishmanial agent-3

Antileishmanial agent-3 (Compound 13) 是一种很有前景的Leishmania major 的生长抑制剂。
T62574 Antileishmanial agent-6

Antileishmanial agent-6 是一种有效的抗利什曼虫剂。Antileishmanial agent-6 对Leishmania donovani 和 L-6 具有抗利什曼虫活性 (IC50: 0.54 μM) 和细胞毒性 (IC50: 10.2 μM) 作用。
T83045 Antileishmanial agent-25

Parasite Microbiology/Virology
Antileishmanial agent-25(compound 24)展现了对胞内无尾线虫的选择性抗力士曼体活性,其半抑制浓度(IC50)为6.63 μM。
TP2331 Leishmania peptide 183

Peptide 183,p183,Leishmania

Leishmania peptide 183 is an antigen.
T79632 Antileishmanial agent-21

Parasite Microbiology/Virology
Antileishmanial agent-21 (compound 4e),是靶向利什曼原虫蝶啶还原酶1 (Lm-PTR1) 的抗利什曼虫试剂。该化合物通过抗叶酸机制发挥作用,且其抗利什曼活性能被叶酸和亚叶酸逆转。Antileishmanial agent-21 还能抑制对 Chloroquine 抗性的恶性疟原虫菌株 (RKL9),IC50 范围为0.0198-0.096 μM。
T79633 Antileishmanial agent-22

Parasite Microbiology/Virology
Antileishmanial agent-22 (compound 15b)是一种抗寄生虫和抗菌化合物,展示了对抗利什曼病、疟疾和结核病的活性。该化合物通过抗叶酸途径抑制利什曼原虫(IC50=0.408 μM)。在100 μM浓度时,Antileishmanial agent-22对叶酸和亚叶酸的抑制率分别达到88%和94%。在体内,以48.4 μM/kg/day剂量对伯氏疟原虫展示96.67%的抑制效果;在体外,其IC50值为0.038 μM。Antileishmanial agent-22还能抑制结核分枝杆菌,MIC值为28.44 μM。
T60638 Antileishmanial agent-8

Antileishmanial agent-8 (compound 18) 对杜氏利什曼原虫 (L. donovani) 显示出有效的和选择性的杀伤活性(IC50 = 5.64 μM),并且对 L-6 细胞显示相对较低的细胞毒性 (IC50=73.9 μM)。
T61560 Antileishmanial agent-5

Antileishmanial agent-4 is a ribonucleoside analogue with potent activity against L.infantum and T.cruzi, having EC 50 values of 0.68 μM and 0.83 μM, respectively [1].
T62330 Antileishmanial agent-12

Antileishmanial agent-12 (compound 5a) 是一种有效的抗利什曼原虫剂,对 Leishmania brazilensis (IC50: 14.9 μM)、Leishmania infantum (IC50: 21.3 μM) 和 T. cruzi (IC50: 9.3 μM) 具有抗原虫作用。
T83666 Kisspeptin-10 (zebrafish) TFA

Tyr-Asn-Leu-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2,Kp-10

Kisspeptin-10是一种在斑马鱼的大脑、卵巢和睾丸中表达的神经肽,参与性腺发育和类固醇表达。在10 ng/ml的浓度下使用时,能提高孤立的斑马鱼卵巢滤泡中编码黄体生成素(luteinizing hormone, Lh)受体,以及孕酮受体a (Progestin receptor a, Pra)和Prb的mRNA水平。在0.1和1 µg/g的剂量下给予时,Kisspeptin-10能在雌性金鱼中增加黄体生成素的血清水平,但在雄性金鱼中则不会。
T78680 Antileishmanial agent-14

Parasite Microbiology/Virology
Antileishmanial agent-14,一种磺胺类类似物,展现了对Leishmaniadonovani promastigotes的潜在活性(IC50=4.1 μM)。该化合物同时对L. donovani amastigotes的感染也具有抑制作用(IC50=11.1 μM)。
T78962 Antileishmanial agent-15

Parasite Microbiology/Virology
Antileishmanial agent-15 (compound 13c) 是针对L. major前鞭毛体和无鞭毛体的高效抗利什曼原虫分子,展现出显著的抗原虫活性和细胞毒性,其IC50值分别为0.78 μM和0.99 μM。
T78964 Antileishmanial agent-17

Parasite Microbiology/Virology
Antileishmanial agent-17是香豆素杂化化合物,展现出优越的抗利什曼原虫活性(IC50<0.78 μM),同时对VERO细胞具备安全性。该化合物通过抑制叶酸代谢途径发挥效用,且在对抗利什曼原虫不同生长阶段表现显著,其IC50值分别对前鞭毛体为0.40 μM,对无鞭毛体为0.68 μM。
T79449 Antileishmanial agent-19

Parasite Microbiology/Virology
Antileishmanial agent-19 (Compound F27)是一种有效的抗利什曼病试剂,其对L. donovani promastigotes的IC50值为3.39 μM。该化合物能够抑制L. donovani promastigotes中的脯氨酰-tRNA合成酶,并干预宿主PI3K/Akt/CREB轴,从而抑制IL-10的分泌。此外,Antileishmanial agent-19能诱导L. donovani promastigotes自噬介导的细胞凋亡(apoptosis)过程,并在感染的动物体内显著减少寄生虫负担。
T72260 Antileishmanial agent-13

Antileishmanial agent-13 是一种喹啉-靛蓝杂交物,可作为抗利什曼病试剂,抑制L. MajorLeishmania 株系。Antileishmanial agent-13 通过抗叶酸机制获得其抗利什曼病活性。Antileishmanial agent-13 对前鞭毛体和无鞭毛体均具有较强的抑制作用,IC50分别为 0.604 μM 和 0.508 μM。

化合物

Light Green SF Yellowish
Cat.No: T20913
Synonym: Acid Green 5,C.I. Acid Green 5,C.I. 42095
Target:
Antileishmanial agent-9
Cat.No: T61416
Synonym:
Target:
Antileishmanial agent-16
Cat.No: T78963
Synonym:
Target: Parasite
Antileishmanial agent-24
Cat.No: T79419
Synonym:
Target: Parasite
Antileishmanial agent-1
Cat.No: T40117
Synonym:
Target:
Rishirilide B
Cat.No: T123912
Synonym:
Target:
Antileishmanial agent-10
Cat.No: T62210
Synonym:
Target:
Antileishmanial agent-4
Cat.No: T61100
Synonym:
Target:
Leishman's stain
Cat.No: T78459
Synonym:
Target:
Antileishmanial agent-20
Cat.No: T79471
Synonym:
Target: Parasite
Bishomoreserpine
Cat.No: T25158
Synonym: Reserpic acid
Target:
Parishin G
Cat.No: T123869
Synonym:
Target:
Antileishmanial agent-11
Cat.No: T63281
Synonym:
Target:
Antileishmanial agent-7
Cat.No: T61710
Synonym:
Target:
Parasin I (catfish) TFA
Cat.No: T83679
Synonym:
Target:
Antileishmanial agent-23
Cat.No: T79390
Synonym:
Target: Parasite
Antileishmanial agent-3
Cat.No: T61391
Synonym:
Target:
Antileishmanial agent-6
Cat.No: T62574
Synonym:
Target:
Antileishmanial agent-25
Cat.No: T83045
Synonym:
Target: Parasite
Leishmania peptide 183
Cat.No: TP2331
Synonym: Peptide 183,p183,Leishmania
Target:
Antileishmanial agent-21
Cat.No: T79632
Synonym:
Target: Parasite
Antileishmanial agent-22
Cat.No: T79633
Synonym:
Target: Parasite
Antileishmanial agent-8
Cat.No: T60638
Synonym:
Target:
Antileishmanial agent-5
Cat.No: T61560
Synonym:
Target:
Antileishmanial agent-12
Cat.No: T62330
Synonym:
Target:
Kisspeptin-10 (zebrafish) TFA
Cat.No: T83666
Synonym: Tyr-Asn-Leu-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2,Kp-10
Target:
Antileishmanial agent-14
Cat.No: T78680
Synonym:
Target: Parasite
Antileishmanial agent-15
Cat.No: T78962
Synonym:
Target: Parasite
Antileishmanial agent-17
Cat.No: T78964
Synonym:
Target: Parasite
Antileishmanial agent-19
Cat.No: T79449
Synonym:
Target: Parasite
Antileishmanial agent-13
Cat.No: T72260
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T4S1820 Parishin

巴利森苷A,派立辛,Parishin A

Others Others
Parishin (Parishin A) A 是一种酚类葡萄糖苷,从天麻中分离得到。Parishin 通过调节 Sir2/Uth1/TOR 信号通路而具有抗衰老作用,并延长酵母寿命。
TMA1603 Parishin C

巴利森苷 C,巴利森苷C

Antioxidant oxidation-reduction
Parishin C 是一种从天麻中分离出的 Parishin 衍生物,可能具有抗氧化作用。
T3S1816 Parishin B

Others Others
Parishin B 是一种分离自天麻中的 Parishin 衍生物,可能具有抗氧化活性。
TN1005 Parishin E

巴利森苷E,巴利森苷 E

Others Others
Parishin E 是一种分离自天麻的 Parishin 衍生物,可能具有抗氧化活性。
TN2452 Parishin D

Others Others
Parishin D is a natural product from Gastrodia elata
T81170 Shishijimicin A

Shishijimicin A是一款从子囊菌Didemnum proliferum中分离出的新型抗肿瘤剂,具备突出的细胞毒性及抗肿瘤活性。作为点击化学试剂,Shishijimicin A内含Alkyne基团,能够与含Azide基团的分子通过铜催化的叠氮-炔环加成反应(CuAAc)进行作用。
T81168 Shishijimicin C

Shishijimicin C 是由子囊菌 Didemnum proliferum 分离得到的一种新型抗肿瘤剂,具有显著的细胞毒性和抗肿瘤活性。作为点击化学试剂,Shishijimicin C 含有Alkyne基团,能够通过铜催化的叠氮-炔环加成反应(CuAAc)与含Azide基团的分子反应。
TN1726 Heishuixiecaoline A

Others Others
Heishuixiecaoline A protects against neurotoxicity in PC12 cells.
T81169 Shishijimicin B

Shishijimicin B为活性的烯二炔类化合物,具有强烈的细胞毒性,IC50值介于2.0 - 3.3 nM。此化合物表现出抗肿瘤活性,常用于癌症研究中。作为点击化学试剂,Shishijimicin B内含Alkyne基团,能通过含Azide基团的分子在铜催化下发生(CuAAc)反应。

天然产物

Parishin
Cat.No: T4S1820
Synonym: 巴利森苷A,派立辛,Parishin A
Target: Others
Parishin C
Cat.No: TMA1603
Synonym: 巴利森苷 C,巴利森苷C
Target: Antioxidant
Parishin B
Cat.No: T3S1816
Synonym:
Target: Others
Parishin E
Cat.No: TN1005
Synonym: 巴利森苷E,巴利森苷 E
Target: Others
Parishin D
Cat.No: TN2452
Synonym:
Target: Others
Shishijimicin A
Cat.No: T81170
Synonym:
Target:
Shishijimicin C
Cat.No: T81168
Synonym:
Target:
Heishuixiecaoline A
Cat.No: TN1726
Synonym:
Target: Others
Shishijimicin B
Cat.No: T81169
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPK-00702 ANTXR2 Protein, Human, Recombinant (His)

cI-35,Antxr2,JHS,CMG-2,CMG2,JHF,HFS,ISH

Human HEK293
The Capillary Morphogenesis Gene 2 (CMG2) gene encodes an Anthrax toxin receptor (ANTXR2),ANTXR2/CMG2 was originally identified as a result of up-regulation during capillary morphogenesis of endothelial cells (ECs) cultured in vitro. ANTXR2/CMG2 functions to promote endothelial proliferation and morphogenesis during sprouting angiogenesis, consistent with the endothelial expression of ANTXR2/CMG2 in several vascular beds.
TMPY-00380 ANTXR2 Protein, Human, Recombinant (hFc)

HFS,JHF,anthrax toxin receptor 2,ISH,CMG-2,CMG2

Human HEK293
Loss-of-function mutations in capillary morphogenesis gene 2 (CMG2/ANTXR2), a transmembrane surface protein, cause hyaline fibromatosis syndrome (HFS), a severe genetic disorder that is characterized by large subcutaneous nodules, gingival hypertrophy and severe painful joint contracture. Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility. A recent genome-wide association study or GWAS ide...
TMPH-03745 TNF-alpha Protein, Zebrafish, Recombinant (His)

Danio rerio (Zebrafish) E. coli
TNF-alpha Protein, Zebrafish, Recombinant (His) is expressed in E. coli with N-terminal 6xHis tag. The predicted molecular weight is 23.6 kDa. Accession number: Q08CQ3
TMPY-03632 EFNB2A Protein, Danio rerio (zebrafish), Recombinant (hFc)

EFNB2A,efnb2,id:ibd572

Danio rerio (zebrafish) HEK293
Efnb2a, also known as ephrin B2a, belongs to the ephrin family. Members of this family are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Efnb2a binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as ...
TMPY-03633 EFNB2A Protein, Danio rerio (zebrafish), Recombinant (His)

efnb2,EFNB2A,id:ibd572

Danio rerio (zebrafish) HEK293
Efnb2a, also known as ephrin B2a, belongs to the ephrin family. Members of this family are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Efnb2a binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as ...
TMPH-03744 IL-1 beta Protein, Zebrafish, Recombinant (His & Myc)

Danio rerio (Zebrafish) E. coli
IL-1 beta Protein, Zebrafish, Recombinant (His & Myc) is expressed in E. coli with N-terminal 10xHis tag and C-terminal Myc tag. The predicted molecular weight is 32.9 kDa. Accession number: E6N152
TMPH-03743 IL-1 beta Protein, Zebrafish, Recombinant (His)

Danio rerio (Zebrafish) E. coli
IL-1 beta Protein, Zebrafish, Recombinant (His) is expressed in E. coli with N-terminal 6xHis tag. The predicted molecular weight is 29.9 kDa. Accession number: E6N152
TMPY-03297 BMP-2 Protein, Danio rerio (zebrafish), Recombinant

bone morphogenetic protein 2

Danio rerio (zebrafish) E. coli
BMP-2 protein, like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. BMP-2 protein is involved in the hedgehog pathway, TGF beta signaling pathway, and cytokine-cytokine receptor interaction. BMP-2 and BMP-7 are osteogenic BMPs that have been demonstrated to potently induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4 and BMP-7 are known to be of major importance in bone formation and repair. In cancerous tissues BMP-2 pr...
TMPH-01189 CISH Protein, Human, Recombinant (GST)

Suppressor of cytokine signaling,Cytokine-inducible SH2-cont...

Human E. coli
CISH Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPY-06725 Jug r 1 Protein, English walnut, Recombinant

English walnut E. coli
Jug r 1 Protein, English walnut, Recombinant is expressed in E. coli. The predicted molecular weight is 17.3 kDa.
TMPY-03080 VEGF165 Protein, Danio rerio (zebrafish), Recombinant

血管内皮生长因子,vascular endothelial growth factor A

Danio rerio (zebrafish) Baculovirus-Insect Cells
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and often exists as a disulfide-linked homodimer. VEGF-A protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular per...
TMPH-02403 JBP1 Protein, Leishmania infantum, Recombinant (His & V5)

Leishmania infantum E. coli
Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Also specifically binds to base J-containing DNA (J-DNA). Involved in propagation and maintenance of DNA base J synthesis i...

重组蛋白

ANTXR2 Protein, Human, Recombinant (His)
Cat.No: TMPK-00702
Species: Human
Expression System: HEK293
ANTXR2 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00380
Species: Human
Expression System: HEK293
TNF-alpha Protein, Zebrafish, Recombinant (His)
Cat.No: TMPH-03745
Species: Danio rerio (Zebrafish)
Expression System: E. coli
EFNB2A Protein, Danio rerio (zebrafish), Recombinant (hFc)
Cat.No: TMPY-03632
Species: Danio rerio (zebrafish)
Expression System: HEK293
EFNB2A Protein, Danio rerio (zebrafish), Recombinant (His)
Cat.No: TMPY-03633
Species: Danio rerio (zebrafish)
Expression System: HEK293
IL-1 beta Protein, Zebrafish, Recombinant (His & Myc)
Cat.No: TMPH-03744
Species: Danio rerio (Zebrafish)
Expression System: E. coli
IL-1 beta Protein, Zebrafish, Recombinant (His)
Cat.No: TMPH-03743
Species: Danio rerio (Zebrafish)
Expression System: E. coli
BMP-2 Protein, Danio rerio (zebrafish), Recombinant
Cat.No: TMPY-03297
Species: Danio rerio (zebrafish)
Expression System: E. coli
CISH Protein, Human, Recombinant (GST)
Cat.No: TMPH-01189
Species: Human
Expression System: E. coli
Jug r 1 Protein, English walnut, Recombinant
Cat.No: TMPY-06725
Species: English walnut
Expression System: E. coli
VEGF165 Protein, Danio rerio (zebrafish), Recombinant
Cat.No: TMPY-03080
Species: Danio rerio (zebrafish)
Expression System: Baculovirus-Insect Cells
JBP1 Protein, Leishmania infantum, Recombinant (His & V5)
Cat.No: TMPH-02403
Species: Leishmania infantum
Expression System: E. coli
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