3
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15572 |
IN-1130
|
ALK | Angiogenesis; Tyrosine Kinase/Adaptors |
IN-1130 是一种选择性的 ALK5 抑制剂,对 ALK5 介导的 Smad3 磷酸化、酪蛋白和 p38α 丝裂原活化蛋白激酶的 ALK5 磷酸化,IC50 值为 5.3 nM、36 nM 和 4.3 μM。 | |||
T11765 |
KPLH1130
|
Dehydrogenase; PDK | Metabolism; PI3K/Akt/mTOR signaling |
KPLH1130,一种选择性丙酮酸脱氢酶激酶(PDK)抑制剂,在高脂饮食(HFD)喂养的小鼠中提高了糖耐量。KPLH1130 抑制巨噬细胞极化并减轻了炎症反应。 | |||
TP1130 |
β-CGRP, human
CGRP-II (Human),Human β-CGRP |
||
β-CGRP, human ,a 37-amino acid peptide,is the beta form of Calcitonin-gene-related peptide (β-CGRP), involved extensively in regulation of the cardiovascular and nervous systems. β-CGRP contains a disulphide bridge at the N-terminus, a C-terminal phenylal |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMA1130 |
2,4-Dihydroxyphenylacetic acid
|
Others | Others |
2,4-Dihydroxyphenylacetic acid is a functional moiety in the toxin molecule and the biological action of spider toxin is explained by direct interaction with an Fe-S center which is known to play an important role for the glutamate binding. |