Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3487 |
HSP70-IN-1
|
Others; HSP | Cytoskeletal Signaling; Metabolism; Others |
HSP70-IN-1是一种热休克蛋白 (HSP) 抑制剂,可抑制 Kasumi-1 细胞的生长,IC50值为2.3 μM。 | |||
T82168 | HSP70/SIRT2-IN-1 | Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
HSP70/SIRT2-IN-1 (Compounds 2a)作为SIRT2与HSP70的双重抑制剂,展示了抗肿瘤活性,其IC50值为17.3±2.0 μM。 | |||
T3515 |
TRC051384 HCl
|
HSP | Cytoskeletal Signaling; Metabolism |
TRC051384 HCl 是热休克蛋白 Hsp70 的诱导剂,可激活热休克因子-1 并增强神经元和神经胶质细胞中 Hsp72 的表达。 | |||
T3527 |
TRC051384
TRC 051384 |
HSP | Cytoskeletal Signaling; Metabolism |
TRC051384 是一种热休克蛋白70 (HSP70) 诱导剂,可减少中风相关的神经元损伤并增加短暂性缺血性中风大鼠模型的存活率,激活热休克因子-1 并导致分子伴侣和抗炎活性升高,增强神经元和神经胶质细胞中 Hsp72 的表达。 | |||
T82167 |
HSP70/SIRT2-IN-2
|
HSP | Cytoskeletal Signaling; Metabolism |
HSP70/SIRT2-IN-2(Compounds 1a)为针对SIRT2与HSP70的双重抑制剂,其IC50值为45.1±5.0 μM,展现了抗肿瘤活性。 | |||
T74278 | HSP70-IN-3 | ||
HSP70-IN-3 是一种有效的热休克蛋白 (HSP70) 抑制剂 (ASZ001 和 C3H10T1/2 的 IC50分别为1.1和1.9 μM)。HSP70-IN-3 具有抗 Hedgehog 信号转导通路活性和抗增殖活性,并降低致癌转录因子 GLI1 的表达。 | |||
T73579 |
YM-1
|
||
YM-1 是稳定的和可溶性的MKT-077 类似物和具有口服活性的Hsp70抑制剂。YM-1 诱导 HeLa 细胞死亡,上调p53和p21的蛋白水平。 | |||
T38045 |
Cholesterol β-D-Glucoside
|
||
Cholesterol β-D-glucoside is a derivative of cholesterol that contains β-D-glucose . It is formed from cholesterol and glucosylceramide by β-glucosidase 1. It activates heat shock transcription factor 1 (Hsf1) in response to heat shock, which increases the expression of heat shock protein 70 (Hsp70) in TIG-3 human fetal lung fibroblasts when used at a concentration of 10 μM. Cholesterol β-D-glucoside (100 mg/kg) prevents ulcer formation following cold-restraint stress and increases Hsf1 activity... | |||
T79487 | MAO A/HSP90-IN-2 | Monoamine Oxidase | Neuroscience |
MAO A/HSP90-IN-2(compound 4-C)是一种针对HSP90和MAO A的双重抑制剂,显示出分别对这两种酶有0.016 μM和4.58 μM的IC50值。该化合物能够上调HSP70,降低HER2和磷酸化AKT的表达,同时能减少GL26细胞中由IFN-γ诱导的PD-L1表达增加。此外,MAO A/HSP90-IN-2能够抑制对Temozolomide敏感或耐药的胶质母细胞瘤(GBM)、结肠癌、白血病和非小细胞肺癌细胞的生长,并可能有助于阻止肿瘤逃避免疫监控。 |