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Search Results for " hsc70 "

Targets Recommended: Apoptosis HSP

抑制剂 & 化合物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T3293	Apoptozole Apoptosis Activator VII	Apoptosis; HSP	Apoptosis; Cytoskeletal Signaling; Metabolism
	Apoptozole (Apoptosis Activator VII) 是一种Hsc70和Hsp70的 ATPase 结构域抑制剂，可诱导凋亡，Kd 值分别为 0.21 和 0.14 μM。
T7010	VER-155008 VER155008	GPR; HSP; Autophagy	Autophagy; Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Metabolism
	VER-155008 是一种Hsp70的抑制剂，对Hsp70、Hsc70 和 Grp7 的IC50值分别为 0.5 μM、2.6 μM 和 2.6 μM，对Hsp70的Kd 值为 0.3 μM，比 HSP90 选择性高 100 倍以上。
TP1616L	Hsp70-derived octapeptide acetate Hsp70-derived octapeptide acetate(736171-62-3 free base)	Others	Others
	Hsp70-derived octapeptide acetate (Hsp70-derived octapeptide acetate)(736171-62-3 free base) 是一组含有四肽重复 (TPR) 的蛋白质，已显示与 70 kDa 热休克同源蛋白 (hsc70) 的 C 末端结构域相互作用。在本研究中，含 TPR 的蛋白质，包括 hsc70 相互作用蛋白 (CHIP)、TPR1 和人富含谷氨酰胺的 TPR 含蛋白 (hSGT) 的 C 端，对 DnaJ 和 hsc70 对荧光素酶重折叠的影响进行了调查。
T27128	DCB-3503 NSC716802,NSC 716802,NSC-716802,DCB3503,DCB 3503
	Tylophorine analog DCB-3503 is a potential anticancer and immunosuppressive agent. DCB-3503 suppresses the translation of cellular regulatory proteins, including cyclin D1, at the elongation step. DCB-3503 allosterically regulates the ATPase and chaperone activities of HSC70 by promoting ATP hydrolysis in the presence of specific RNA binding motifs (AUUUA) of cyclin D1 mRNA.
TP1616	Hsp70-derived octapeptide
	A group of tetratricopeptide repeat (TPR)-containing proteins has been shown to interact with the C-terminal domain of the 70 kDa heat-shock cognate protein (hsc70). In the present study, the effect of the TPR-containing proteins, including the C-terminus
T28266	Org-6906 Org6906,Org 6906,Org-6906 free
	Tylophorine analog Org-6906 is a potential anticancer and immunosuppressive agent. Org-6906 suppresses the translation of cellular regulatory proteins, including cyclin D1, at the elongation step. Org-6906 allosterically regulates the ATPase and chaperone activities of HSC70 by promoting ATP hydrolysis in the presence of specific RNA binding motifs (AUUUA) of cyclin D1 mRNA.

化合物

Apoptozole

Cat.No: T3293

Synonym: Apoptosis Activator VII

Target: Apoptosis, HSP

VER-155008

Cat.No: T7010

Synonym: VER155008

Target: GPR, HSP, Autophagy

Hsp70-derived octapeptide acetate

Cat.No: TP1616L

Synonym: Hsp70-derived octapeptide acetate(736171-62-3 free base)

Target: Others

DCB-3503

Cat.No: T27128

Synonym: NSC716802,NSC 716802,NSC-716802,DCB3503,DCB 3503

Target:

Hsp70-derived octapeptide

Synonym: Org6906,Org 6906,Org-6906 free

Target:

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02217	HSC70 Protein, Human, Recombinant (His) HSP73,HSC54,HSP71,NIP71,LAP-1,HEL-33,HSPA10,HSC...	Human	E. coli
	HSPA8, also known as HSC70, is a member of the heat shock protein family due to homology with other heat shock proteins. The heat shock protein 70 family is comprised of both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. HSPA8 belongs to the heat-shock cognate subgroup. Members of the human heat-shock protein multigene family have several highly conserved proteins with structural and functional properties in common but vary in the extent ...
TMPJ-00717	BAG2 Protein, Human, Recombinant (His) BAG-2,BAG Family Molecular Chaperone Regulator 2,BAG2,Bcl-2-...	Human	E. coli
	BAG Family Molecular Chaperone Regulator 2 (BAG2) is a member of the Bag family whose members compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. BAG2 contains 1 BAG domain and is a important component of the HSC 70/CHIP chaperone-dependent ubiquitin ligase complex. In mammalian cells BAG1, BAG2, and BAG3 bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
TMPJ-00679	SGTA Protein, Human, Recombinant (His) α-SGT,Alpha-SGT,SGT,Small Glutamine-Rich Tetratricopeptide R...	Human	E. coli
	Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein α (SGTA) is an ubiquitously expressed protein which belongs to the SGT Family. SGTA contains three TPR Protein-Protein Interaction Duplicates. SGTA is a co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. SGTA is capable of interacting with the major nonstructural protein of Parvovirus H-1 and 70-kDa heat shock cognate protein. It interacts with NS1 from Parvovirus H-1, with Vpu and Gag from HIV...
TMPJ-00915	HSP40 Protein, Human, Recombinant (His) HDJ1,HSPF1,DNAJ1,Heat Shock 40 kDa Protein 1,HSP40,hDj-1,DNA...	Human	E. coli
	DnaJ Homolog Subfamily B Member 1 (DNAJB1) is a member of the heat shock protein family. Heat shock proteins (HSPs) are a highly conserved family of stress response proteins. HSPs function primarily as molecular chaperones, facilitating the folding of other cellular proteins, preventing protein aggregation, or targeting improperly folded proteins to specific degradative pathways. DNAJB1 regulates cellular processes by aiding in the folding, transport and assembly. DNAJB1 contains a J-domain whic...
TMPJ-01386	STUB1 Protein, Human, Recombinant Carboxy Terminus of Hsp70-Interacting Protein,STIP1...	Human	E. coli
	E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation....