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11

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T14342	Atorvastatin lactone	HMG-CoA Reductase	Metabolism
	Atorvastatin lactone 是一种 Atorvastatin 的前药。其中 Atorvastatin 是口服具有活力的 3- 羟基 -3- 甲基戊二酰辅酶 A 还原酶抑制剂。
T28009	ME-3221 ME3221
	Apomine is an inhibitor of HMG-CoA-reductase. It promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo. Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-meth
T26644	Apomine SK&F-99085,APB-231-A2,APB-231-A-2,SR-9223i,SK&F-99085,SR-45023A	HMG-CoA Reductase	Metabolism
	Apomine (SR-9223i) 是一种 HMG-CoA-还原酶抑制剂，可在体外促进骨髓瘤细胞的凋亡，并与体内骨髓瘤的调节有关。 Apomine 加速 3-羟基-3-甲基戊二酰-CoA 还原酶的降解并刺激低密度脂蛋白受体活性。 Apomine 通过下调 3-羟基-3-甲基戊二酰-CoA 还原酶来增强洛伐他汀对骨髓瘤细胞的抗肿瘤作用。
T10132	(3S,5S)-Pitavastatin calcium	Others	Others
	(3S,5S)-Pitavastatin calcium is the 3-epimer of Pitavastatin which is a potent HMG-CoA reductase inhibitor.
T72155	(Rac)-3′-Hydroxy simvastatin
	(Rac)-3′-Hydroxy simvastatin 是一种 Simvastatin 代谢物。Simvastatin 是一种竞争性的 HMG-CoA 还原酶抑制剂，Ki 值为 0.2 nM。
T10120	3-Oxo Atorvastatin	Others	Others
	3-Oxo Atorvastatin is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.
T12283	O-Methyl Atorvastatin hemicalcium	Others	Others
	O-Methyl Atorvastatin is an impurity of Atorvastatin that is an orally active inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, has the ability to effectively decrease blood lipids.
T10399	Atorvastatin 3-Deoxyhept-2E-Enoic Acid (2E)-2,3-Dehydroxy Atorvastatin	Others	Others
	Atorvastatin 3-Deoxyhept-2E-Enoic Acid is an impurity of Atorvastatin. Atorvastatin is an HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.
T36827	Acetoacetyl Coenzyme A (sodium salt hydrate) Acetoacetyl-CoA
	Acetoacetyl-coenzyme A (acetoacetyl-CoA) is a precursor to HMG-CoA in the isoprenoid pathway.[1],[2] It is reversibly converted to acetyl-CoA by acetoacetyl-CoA thiolase in the mitochondria. Acetoacetyl-CoA thiolase (T2) deficiency results in a build-up of ketone bodies leading to intermittent ketoacidosis.[3],[4] Acetoacetyl-CoA is also an intermediate in the microbial biosynthesis of polyhydroxybutyrate.[5]
T36863	Geranylgeranyl Pyrophosphate (ammonium salt) Geranylgeranyl Pyrophosphate (ammonium salt),GGPP
	Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids.[1] It is also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.[2] This post-translational modification is necessary for correct localization of proteins to intracellular membranes for proper functionality and has become a focus of anticancer drug disco...
T35718	N-desmethyl Rosuvastatin (sodium salt hydrate)
	N-desmethyl Rosuvastatin is an active metabolite of the HMG-CoA reductase inhibitor rosuvastatin .1,2N-desmethyl Rosuvastatin is formed when rosuvastatin undergoes demethylation, primarily by the cytochrome P450 (CYP) isoform CYP2C9 and to a lesser extent by CYP2C19 and CYP3A4.1 1.Macwan, J.S., Ionita, I.A., and Akhlaghi, F.A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tand...

化合物

Atorvastatin lactone

Cat.No: T14342

Target: HMG-CoA Reductase

Cat.No: T28009

Synonym: ME3221

Cat.No: T26644

Synonym: SK&F-99085,APB-231-A2,APB-231-A-2,SR-9223i,SK&F-99085,SR-45023A

Target: HMG-CoA Reductase

(3S,5S)-Pitavastatin calcium

Cat.No: T10132

Target: Others

(Rac)-3′-Hydroxy simvastatin

Cat.No: T72155

3-Oxo Atorvastatin

Cat.No: T10120

Target: Others

O-Methyl Atorvastatin hemicalcium

Cat.No: T12283

Target: Others

Atorvastatin 3-Deoxyhept-2E-Enoic Acid

Cat.No: T10399

Synonym: (2E)-2,3-Dehydroxy Atorvastatin

Target: Others

Acetoacetyl Coenzyme A (sodium salt hydrate)

Cat.No: T36827

Synonym: Acetoacetyl-CoA

Geranylgeranyl Pyrophosphate (ammonium salt)

Cat.No: T36863

Synonym: Geranylgeranyl Pyrophosphate (ammonium salt),GGPP

N-desmethyl Rosuvastatin (sodium salt hydrate)

Cat.No: T35718

Cat. No.	Product Name	Target	Signaling Pathways
T1664	Meglutol Dicrotalic acid,3-Hydroxy-3-methylglutaric acid,美格鲁托	Endogenous Metabolite; HMG-CoA Reductase; Autophagy	Autophagy; Metabolism
	Meglutol (3-Hydroxy-3-methylglutaric acid) 是一种抗血脂剂，可降低胆固醇、甘油三酯、血清 β-脂蛋白和磷脂。它抑制胆固醇生物合成中的限速酶羟甲基戊二酰辅酶 A 还原酶的活性。
T35400	β-Muricholic Acid β-MCA,5β-Cholanic Acid-3α,6β,7β-triol,β-Muricholic Acid
	β-Muricholic acid (β-MCA) is a murine-specific primary bile acid.[1],[2] Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.[3] Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.[4]

天然产物

Cat.No: T1664

Synonym: Dicrotalic acid,3-Hydroxy-3-methylglutaric acid,美格鲁托

Target: Endogenous Metabolite, HMG-CoA Reductase, Autophagy

β-Muricholic Acid

Cat.No: T35400

Synonym: β-MCA,5β-Cholanic Acid-3α,6β,7β-triol,β-Muricholic Acid

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