10
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T79974 |
HIV-IN-8
|
||
HIV-IN-8(Compound 9)为抗HIV药物,通过抑制HIV复制发挥作用,其半抑制浓度(EC50)为13 μg/mL。 | |||
T78950 | HIV-1 protease-IN-8 | HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-1protease-IN-8(compound 34b)是一款高效的HIV-1蛋白酶抑制剂,其IC50为0.32 nM。该化合物对野生型HIV-1(HIV-1NL4-3)及耐药变体(HIV-1MDR)的IC50分别为0.29 μM与1.90 μM,表明其对这两种型别均展现出显著的抗病毒效果。 | |||
T60742 |
HIV-1 integrase inhibitor 8
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-1 integrase inhibitor 8 是一种 HIV-1 整合酶抑制剂,整合是HIV 复制的必要步骤。 | |||
T12818 |
S119-8
|
Influenza Virus | Microbiology/Virology |
S119-8 是一种广谱甲型和乙型流感病毒抑制剂,抑制多种乙型流感病毒和耐奥司他韦的甲型流感病毒。 | |||
T11549 |
Helioxanthin 8-1
Helioxanthin analogue 8-1 |
Others | Others |
Helioxanthin 8-1, an analogue of helioxanthin, exhibits significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 μM. | |||
T78737 |
NNRTIs-IN-3
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
NNRTIs-IN-3(化合物8)作为一种HIV-1非核苷逆转录酶抑制剂,表现出较高的效力(EC50=0.01 µM)。 | |||
T79828 |
DGKα-IN-8
|
||
DGKα-IN-8(Example 51)是DGKα的高效抑制剂,其IC50值为22.491 nM,EC50值为0.256 nM。该化合物主要用于癌症(含实体瘤)及HIV和乙型肝炎病毒感染的研究领域。 | |||
T70856 |
3-Oxobetulin Acetate
|
||
3-Oxobetulin acetate is a derivative of the cholesterol biosynthesis inhibitor betulin. It inhibits the growth of P388 murine lymphocytic leukemia cells (EC50 = 0.12 µg/ml), as well as human MCF-7 breast, SF-268 CNS, H460 lung, and KM20L2 colon cancer cells (GI50s = 8, 10.6, 5.2, and 12.7 µg/ml, respectively), but not BxPC-3 pancreas or DU145 prostate cancer cells (GI50s = >10 µg/ml for both). 3-Oxobetulin acetate inhibits replication of X4 tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblasto... | |||
T35762 | MC1742 | ||
MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).1 It is selective for class I and class IIb over class IIa HDACs (IC50s = >50 μM for HDAC4, -5, -7, and -9). MC1742 reduces proliferation of HOS, MG-63, RD, A204, SK-ES-1, and A673 sarcoma cancer stem cells (CSCs). It increases levels of acetylated histone H3 and acetylated tubulin... | |||
T35406 |
α-MSH TFA
|
||
α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC50s = 0.16 and 56 nM, respectively).2α-MSH (100 pM) reducesS. aureuscolony formation andC. albicansgerm tube fo... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5429 |
Theaflavin 3,3'-digallate
茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG |
Virus Protease; Antioxidant; HIV Protease; HSV | Microbiology/Virology; oxidation-reduction; Proteases/Proteasome |
Theaflavin 3,3'-digallate (8-Gingerol) 是一种寨卡病毒蛋白酶抑制剂,IC50为 2.3 μM。它直接与 ZIKVpro 结合并抑制 ZIKV 复制,可抑制 gp41 和 NS2B-3 蛋白酶的活性,并具有抗 HSV 和 HIV-1病毒活性。它是红茶中的主要多酚,有抗肿瘤作用。 | |||
T36000 |
3-Hydroxyterphenyllin
|
||
3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi... |