Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7791 |
Iberdomide
CC-220 |
Apoptosis; Ligand for E3 Ligase | Apoptosis; PROTAC |
Iberdomide (CC-220) 是一种口服有效的 cereblon E3 连接酶调节剂,对 cereblon 结合亲和力的 IC50约为150 nM。它是沙利度胺的衍生物,具有抗肿瘤和免疫刺激活性。 | |||
T14918 |
CDK9-IN-2
N2'-(反式-4-氨基环己基)-5'-氯-N6-[(3-氟苯基)甲基]-[2,4'-联吡啶]-2',6-二胺 |
Others; CDK | Cell Cycle/Checkpoint; Others |
CDK9-IN-2 是一种特异性CDK9抑制剂。它在 A2058 皮肤细胞系(72 小时)和 H929 多发性骨髓瘤细胞系(72小时)的IC50分别为 7 nM 和 5 nM。 | |||
T7522 |
GI254023X
GI 254023X |
MMP; Immunology/Inflammation related | Immunology/Inflammation; Proteases/Proteasome |
GI254023X 是MMP9和ADAM10抑制剂,它们的IC50s 分别为 2.5 和 5.3 nM。 | |||
T69766 | Gusacitinib HCl | ||
Gusacitinib, also known as ASN-002 and EN-3351, is a potent dual inhibitor of SYK/JAK kinases. ASN002 showed strong antitumor activity in both hematological and solid tumor xenograft models. ASN002 strongly suppressed the SYK and JAK family kinase signaling pathways as measured in pLAT and pSTAT assays, respectively. When profiled in a panel of 178 cell lines, ASN002 showed strong anti-proliferative activity in many lymphoid/leukemia cell lines, including SU-DHL-6, SU-DHL-4, OCI-LY10, H929 and... | |||
T28498L |
rac-CCT-250863 HCl
rac-CCT-250863 HCl(1364269-06-6 Free base) |
Apoptosis | Apoptosis |
rac-CCT-250863 HCl 是一种具有选择性和可逆性的 NEK 2 抑制剂。rac-CCT-250863 HCl 能诱导细胞周期停滞,对癌细胞有较好的抗增殖活性,与 Pomalidomide 联用能诱导细胞凋亡,可用于联合抗癌的研究。 |