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Search Results for " h5n1 "

18

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9231	Mbx2329	Antiviral	Immunology/Inflammation
	MBX2329 是一种流感病毒抑制剂，能特异性地抑制血凝素介导的病毒进入，HIV/HA(H5) 的 IC90值为8.6 μM。它能够有效地抑制多种甲型流感病毒。
T74774	Neuraminidase-IN-16
	Neuraminidase-IN-16 (Compound 43b) 是一种有效的神经氨酸酶 (neuraminidase) 抑制剂，对 H5N1、H5N8、H1N1、H3N2、H5N1–H274Y 和 H1N1–H274Y 的神经氨酸酶抑制作用的 IC50分别为 0.031、0.15、0.25、0.60、0.63 和 10.08 μM。
T27038	CL385319 HCl CL-385319,CL385319 hydrochloride,CL 385319,CL385319
	CL385319 is a potent inhibitor of H5N1 avian influenza A virus infection by blocking viral entry. CL-385319 is effective in inhibiting infection of highly pathogenic H5N1 influenza A virus in Madin-Darby Canine Kidney (MDCK) cells with an IC50 of 27.03±2.
T37466	CAY10766
	CAY10766 is an antiviral compound.1It inhibits entry of influenza virus-like particles pseudotyped with hemagglutinin A (HA) from H5N1 influenza A virus into A549 cells (EC50= 0.24 μM). CAY10766 (1 μM) reduces H1N1 and H5N1 influenza A viral titers in infected MDCK cells. It also exhibits synergy with oseltamivir carboxylate in MDCK cells infected with the influenza A reporter PR8-NS1-Gluc virus.
T71856	FA-613
	FA-613 is a pyrimidine synthesis inhibitor which exhibits low micromolar antiviral activity against various influenza A and B virus strains, including the highly pathogenic influenza A strains H5N1 and H7N9, enterovirus A71, respiratory syncytial virus, human rhinovirus A, SARS- and MERS-coronavirus.
T63233	Neuraminidase-IN-10
	Neuraminidase-IN-10 是神经氨酸酶 (neuraminidase) 抑制剂，表现出抗流感作用，能够作用于 H1N1 (IC50: 2.6 nM)、H5N1 (IC50: 5.1 nM) 和 H5N8 (IC50: 1.65 nM)。
T63175	Neuraminidase-IN-3
	Neuraminidase-IN-3 (compound 23d) 是一种流感神经氨酸酶 (NA) 的有效抑制剂，能够作用于 H1N1 (IC50: 0.73 nM)、H5N1 (IC50: 0.26 nM) 和 H5N8 NAs (IC50: 0.63 nM)。
T62345	Neuraminidase-IN-4
	Neuraminidase-IN-4 (Compound 4b) 是一种 neuraminidase 的有效抑制剂 (EC50: 1.59 μM)。神经氨酸酶（NA）是治疗流感的重要靶点。Neuraminidase-IN-4 对 A/chicken/Hubei/327/2004 (H5N1-DW) 表现出显著的抗病毒作用。
T63754	Neuraminidase-IN-9
	Neuraminidase-IN-9 (Compound 6l) 是流感病毒神经氨酸酶 (influenzaneuraminidase) 的有效抑制剂，能够作用于 H5N1 (IC50: 0.12 μM)、H5N2 (IC50: 0.049 μM) 和 H5N6 (IC50: 0.16 μM)。
T64274	Neuraminidase-IN-11
	Neuraminidase-IN-11 (15e) 是一种选择性的、有效的神经氨酸酶 (NA) 抑制剂，能够作用于 H1N1 病毒的神经氨酸酶 (IC50: 4.7 nM)、H5N1 病毒的神经氨酸酶 (IC50: 8.46 nM) 和 H5N8 病毒的神经氨酸酶 (IC50: 1.5 nM)。
T62837	Influenza virus-IN-3
	Influenza virus-IN-3 (compound 9) 是一种选择性流感病毒的有效抑制剂，能够作用于 H5N1 (IC50: 0.88 μM)、H5N2 (IC50: 0.10 μM)、H5N6 (IC50: 5.5 μM)、H5N8 (IC50: 0.51 μM)。Influenza virus-IN-3 具有抗病毒和 NA (神经氨酸酶) 抑制作用，且细胞毒性低 (CC50>200 μM)。
T73347	BCX-1898
	BCX-1898 是一种环戊烷衍生物，是口服有效的，选择性的流感病毒神经氨酸酶 (influenza virus neuraminidase) 抑制剂。BCX-1898 具有抗病毒活性，对 MDCK 细胞中的甲型流感病毒 (H1N1、H3N2、H5N1) 和乙型流感病毒复制的 EC50值为 <0.01-21 μM。BCX-1898 显示出对小鼠流感模型的保护作用。
T77009	Firivumab
	Firivumab (CT-P22; CT120)是一种针对人类IgG1单克隆的抗甲型流感病毒血凝素（Anti-IAV HA）抗体。该抗体能有效中和多种亚型，包括H1N1、H5N1、H6N1、H6N2、H8N4、H8N8、H9N2和H12N7。研究发现，Firivumab在小鼠模型中对H1N1病毒展现出显著的保护效果。
T62197	Influenza virus-IN-4
	Influenza virus-IN-4 (compound 11e) 是一种流感病毒神经氨酸酶的有效抑制剂，能够作用于 H5N1 (IC50: 3.4 μM)、H5N2 (IC50: 0.094 μM)、H5N6 (IC50: 0.79 μM)、H5N8 (IC50: 0.077 μM)。Influenza virus-IN-4 能够抑制 NA（神经氨酸酶），并具有低细胞毒性(CC50>200 μM)。Influenza virus-IN-4 在1500 mg/kg 时，对小鼠没有明显的毒性。
T69398	LUN15104
	LUN15104 is a novel hemagglutinin (HA) protein inhibitor, inhibiting entry and replication of diverse influenza viruses via the HA protein, showing potent antiviral activity against diverse H1N1, H5N1, and H3N2 influenza viruses encoding HA proteins from both groups 1 and 2. This product has no formal name. For the convenience of scientific communication, we named it by combining its InChi Key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKo...
T70207	Pimodivir tosylate
	Pimodivir, also known as VX-787, JNJ-872, is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. VX-787 binds the cap-binding domain of the PB2 subunit with a KD (dissociation constant) of 24 nM as determined by isothermal titration calorimetry (ITC). The cell-based EC50 (the concentration of compound that ensures 50% cell viability of an uninfected control) for VX-787 is 1.6 nM in a cytopathic effect (CPE) assay...
T62346	Neuraminidase-IN-7
	Neuraminidase-IN-7 (compound 4b) 是一种噻吩衍生物，是一种神经氨酸酶 (neuraminidase) 的有效抑制剂 (IC50: 0.03 μM)。Neuraminidase-IN-7 对 A/chicken/Hubei/327/2004 (H5N1-DW) 表现出显著的抗病毒作用 (EC50: 1.59 μM)。Neuraminidase-IN-7 具有潜力进行流感的研究。
T62812	RdRP-IN-4
	RdRP-IN-4 (compound 11q) 是一种芳基苯甲酰肼类似物，是一种口服具有活力的甲型流感病毒 RNA 依赖性 RNA 聚合酶 (RdRp) 抑制剂，能够直接结合 RdRp 的 PB1 亚基。RdRP-IN-4 可有效抑制 H5N1 禽流感病毒株，在 MDCK 细胞的 EC50=18 nM。RdRP-IN-4 对 H1N1 (A/PR/8/34) Flu A 株和 Flu B 株 (B/Lee/1940) 具有抑制作用，其 EC50 值分别为 53 nM 和 20 nM。RdRP-IN-4 以剂量依赖性方式显著抑制病毒核蛋白 (NP) 的表达水平。RdRP-IN-4 在受感染的小鼠中具有明显的抗病毒作用。

化合物

Cat.No: T9231

Target: Antiviral

Neuraminidase-IN-16

Cat.No: T74774

Cat.No: T27038

Synonym: CL-385319,CL385319 hydrochloride,CL 385319,CL385319

Cat.No: T37466

Cat.No: T71856

Neuraminidase-IN-10

Cat.No: T63233

Neuraminidase-IN-3

Cat.No: T63175

Neuraminidase-IN-4

Cat.No: T62345

Neuraminidase-IN-9

Cat.No: T63754

Neuraminidase-IN-11

Cat.No: T64274

Influenza virus-IN-3

Cat.No: T62837

Cat.No: T73347

Cat.No: T77009

Influenza virus-IN-4

Cat.No: T62197

Cat.No: T69398

Pimodivir tosylate

Cat.No: T70207

Neuraminidase-IN-7

Cat.No: T62346

Cat.No: T62812

Cat. No.	Product Name	Target	Signaling Pathways
T4S1114	Dryocrassin ABBA 东北贯众素,Dryocrassin	Influenza Virus; Antibacterial	Microbiology/Virology
	Dryocrassin ABBA (Dryocrassin) 是一种从苦参中提取的黄酮类天然产物，具有抗病毒和抗菌活性。它抑制树突状细胞的免疫刺激功能，延长同种异体皮肤移植成活率。
TN1262	3-Feruloylquinic acid 3-O-阿魏酰奎尼酸,3-O-Feruloylquinic acid	Proteasome; Antifection	Microbiology/Virology; Proteases/Proteasome; Ubiquitination
	3-O-Feruloylquinic acid is a protease inhibitor, it exerts moderate inhibitory effect against AIV (H5N1) in vitro.
T26288	Clovamide trans-Clovamide,N-trans-Caffeoy-L-dopa	Apoptosis; Influenza Virus; ROS; Antibacterial	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Clovamide (trans-Clovamide) 是一种天然存在的咖啡酰结合物，具有抗菌、抗炎、抗氧化和神经保护作用。它是一种极好的活性氧和氧自由基清除剂。
T11364	Ganoderic acid TR	Others	Others
	Ganoderic acid TR is a broad-spectrum inhibitor against influenza neuraminidases (NAs), particularly H1N1 and H5N1 neuraminidases. The IC50 values of 4.6 and 10.9 μM, respectively.
TN4105	Ganoderic acid T-Q	Others	Others
	Ganoderic acid T-Q and TR are two inhibitors of H5N1 and H1N1 NAs.
TN1066	Filixic acid ABA	Influenza Virus	Microbiology/Virology
	Filixic acid ABA exhibits inhibitory effects on neuraminidase of influenza virus H5N1 with IC50 as 29.57 ± 2.48 μM, it may have anti-influenza virus activity.
TN3461	Asebotin	Influenza Virus	Microbiology/Virology
	Asebotin shows anti-influenza A virus activity, it also possesses potent antiviral activity (100% inhibition at the concentration of 1 ug /mL) against highly pathogenic avian influenza strain H5N1. Asebotin can inhibit the proliferation of murine B cells.

天然产物

Dryocrassin ABBA

Cat.No: T4S1114

Synonym: 东北贯众素,Dryocrassin

Target: Influenza Virus, Antibacterial

3-Feruloylquinic acid

Cat.No: TN1262

Synonym: 3-O-阿魏酰奎尼酸,3-O-Feruloylquinic acid

Target: Proteasome, Antifection

Cat.No: T26288

Synonym: trans-Clovamide,N-trans-Caffeoy-L-dopa

Target: Apoptosis, Influenza Virus, ROS, Antibacterial

Ganoderic acid TR

Cat.No: T11364

Target: Others

Ganoderic acid T-Q

Cat.No: TN4105

Target: Others

Filixic acid ABA

Cat.No: TN1066

Target: Influenza Virus

Cat.No: TN3461

Target: Influenza Virus

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