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7

抑制剂 & 化合物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T36577	K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt) K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)
	Histone H2B (108-125) is a peptide fragment of histone H2B that corresponds to amino acid residues 109-126 of the human histone H2B sequence. It contains an N-terminal biotinylated lysine followed by a tryptophan linker. Histone H2B can be modified by addition of an O-linked N-acetylglucosamine (GlcNAc) moiety to the serine residue at position 112, which promotes monoubiquitination of the lysine at position 120.1 Both of these modifications are associated with active transcription. Histone H2B a...
T11563	Histone Acetyltransferase Inhibitor II	Epigenetic Reader Domain; Histone Acetyltransferase	Chromatin/Epigenetic
	Histone Acetyltransferase Inhibitor II 是一种选择性的细胞渗透性 p300 组蛋白乙酰转移酶抑制剂，IC50值为 5 µM。它在哺乳动物细胞中具有抗乙酰化酶活性，可用于癌症研究。
T36095	Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt) Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)
	Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt) 可用于生命科学领域的相关研究，其产品编号为 T36095。
T38814	BocNH-PEG5-CH2CH2Br BocNH-PEG5-CH2CH2Br
	BocNH-PEG5-CH2CH2Br is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
TP1903	PKG inhibitor peptide cGMP Dependent Kinase Inhibitor Peptide
	Competitive inhibitor of cGMP-dependent protein kinase (PKG); analog of a substrate peptide corresponding to a phosphorylation site of histone H2B. Competes with synthetic substrates (Ki = 86 mM) but does not inhibit phosphorylation of intact histones by
T36856	UA 62784
	Inhibitor of microtubule polymerization in vitro. Interacts with tubulin dimers and promotes the accumulation of mammalian cells in apoptosis. Potentiates antiproliferative effects of vinblastine in H2B-GFP HeLa cells. Originally thought to inhibit CENP-E ATPase activity. Tcherniuk et al (2011) UA62784 is a cytotoxic inhibitor of microtubules, not CENP-E. Chem.Biol. 18 631 PMID:21609844 \|Maiato and Logarinho et al (2011) Motor-dependent and -independent roles of CENP-E at kinetochores: the cauti...
T75810	AKTide-2T TFA
	AKTide-2T TFA 是一个优良的体外AKT 底物，可竞争性抑制组蛋白 H2B 磷酸化，其Ki 值为 12 nM。AKTide-2T TFA 模拟Akt 的磷酸化序列，是一种抑制肽，是 S22 位置中缺失了野生型 AKTide。

化合物

K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)

Cat.No: T36577

Synonym: K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)

Histone Acetyltransferase Inhibitor II

Cat.No: T11563

Target: Epigenetic Reader Domain, Histone Acetyltransferase

Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)

Cat.No: T36095

Synonym: Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt)

BocNH-PEG5-CH2CH2Br

Cat.No: T38814

Synonym: BocNH-PEG5-CH2CH2Br

PKG inhibitor peptide

Cat.No: TP1903

Synonym: cGMP Dependent Kinase Inhibitor Peptide

Cat.No: T36856

Cat.No: T75810

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02510	HIST2H2BE Protein, Human, Recombinant MGC129734,H2BGL105,H2B.1,histone cluster 2...	Human	E. coli
	Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. Histone proteins exhibit two levels of diversity: 1. evolutionary diversity between species and 2. subtype diversity in a class(H1, H2A, H2B, H3 or H4) within a species. It has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enz...
TMPH-01481	H2BC12 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	H2BC12 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-02711	HIST1H2BM Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. HIST1H2BM Protein, Mouse, Recombinant (His) is expressed in E...
TMPH-02710	HIST1H2BA Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	HIST1H2BA Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli.
TMPH-01480	H2BC3 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	H2BC3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-01985	ASAH2B Protein, Human, Recombinant (His) ASAH2L,ASAH2B,Putative inactive non-lysosomal ceram...	Human	E. coli
	N/A. ASAH2B Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.0 kDa and the accession number is P0C7U1.
TMPY-02521	HIST3H2A Protein, Human, Recombinant histone cluster 3, H2a,MGC3165	Human	E. coli
	Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enzymatic machinery that set them are crucial regulators that can control cellular proliferation, differentiation,...
TMPH-00095	HDT2 Protein, Arabidopsis thaliana, Recombinant (His)	Arabidopsis thaliana	P. pastoris (Yeast)
	Probably mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDT2 Protein, Arabidopsis thaliana, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 34.3 kDa and the accession number is Q56WH4.
TMPH-01472	HDAC11 Protein, Human, Recombinant (GST)	Human	E. coli
	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC11 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 66....
TMPY-02496	Rad6/UBE2A Protein, Human, Recombinant (His) UBC2,HHR6A,MRXS30,MRXSN,RAD6A,ubiquitin-conjugating enzyme E...	Human	E. coli
	Ubiquitin-conjugating enzyme E2 A (also known as HHR6A or UBE2A), encoded by human DNA repair genes HHR6A, belongs to the ubiquitin-conjugating enzymes (E2 enzymes) family and is likely to be involved in postreplication repair and induced mutagenesis. UBE2A is described as a CDK2 substrate. It is the human homologue of the product of the Saccharomyces cerevisiae RAD6 / UBC2 gene, a member of the family of ubiquitin-conjugating enzymes. In vivo, HHR6A phosphorylation peaks during the G2/M phase o...
TMPY-01332	HIST1H3A Protein, Human, Mouse, Recombinant Histone H3.1,histone cluster 1, H3a,Histone H3	Human,Mouse	E. coli
	Histone H3.1, also known as HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, is a member of the histone H3 family which is a core component of nucleosome. It is expressed during the S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machinery which requires DNA as a template. Histones thereby pla...
TMPH-01267	RNF13 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of hist...

重组蛋白

HIST2H2BE Protein, Human, Recombinant

Cat.No: TMPY-02510

Species: Human

Expression System: E. coli

H2BC12 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01481

Species: Human

Expression System: E. coli

HIST1H2BM Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02711

Species: Mouse

Expression System: E. coli

HIST1H2BA Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02710

Species: Mouse

Expression System: E. coli

H2BC3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01480

Species: Human

Expression System: E. coli

ASAH2B Protein, Human, Recombinant (His)

Cat.No: TMPH-01985

Species: Human

Expression System: E. coli

HIST3H2A Protein, Human, Recombinant

Cat.No: TMPY-02521

Species: Human

Expression System: E. coli

HDT2 Protein, Arabidopsis thaliana, Recombinant (His)

Cat.No: TMPH-00095

Species: Arabidopsis thaliana

Expression System: P. pastoris (Yeast)

HDAC11 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01472

Species: Human

Expression System: E. coli

Rad6/UBE2A Protein, Human, Recombinant (His)

Cat.No: TMPY-02496

Species: Human

Expression System: E. coli

HIST1H3A Protein, Human, Mouse, Recombinant

Cat.No: TMPY-01332

Species: Human,Mouse

Expression System: E. coli

RNF13 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01267

Species: Human

Expression System: E. coli

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