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37

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19596	UDP-GlcNAc Disodium Salt Uridine 5′-diphospho-N-acetylglucosamine,5′-二磷酸尿嘧啶核苷-N-乙酰半乳糖胺二钠盐,UDP-α-D-N-Acetylglucosamine Disodium Salt	Others	Others
	UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) 是一种 O-GlcNAc 转移酶 (OGT) 的供体底物。
T9190	NAG-thiazoline GlcNAc-thiazoline,N-乙酰 - 葡糖胺基噻唑啉	Others	Others
	NAG-thiazoline (GlcNAc-thiazoline) 是一种 O-GlcNAcase 抑制剂，Ki 值为 180 nM。它对 V. campbellii 有效，MIC 值为 0.5 µM。
T38713	Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH Fmoc-Asn(Ac3AcNH-beta-Glc)-OH,Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH
	Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH, also known as Fmoc-Asn(Ac3AcNH-beta-Glc)-OH, is a chemical compound used in the synthesis of silicon-fluoride acceptor (SiFA) derivatized octreotate derivatives. SiFA-octreotate analogues, which serve as tumor imaging agents, are valuable tools for positron emission tomography (PET) research.
T83131	AMC-GlcNAc
	AMC-GlcNAc (compound 1) 作为一款高效荧光探针，主要用于β-己糖胺酶活性的检测与表征。该探针能在连续监测中开启荧光，并且在宽广pH值范围内维持稳定的荧光信号（Ex=325 nm, Em=390 nm）。AMC-GlcNAc还支持高灵敏度与低背景信号的比率荧光检测，适用于筛选大肠杆菌细胞裂解物中重组分散素B的活性。
T75405	GlcNAc kinase (EcNagK)
	GlcNAc kinase (EcNagK) (N-Acetylglucosamine kinase) 为GlcNAc代谢过程中的关键酶。通过将ATP的γ-磷酰基转移到GlcNAc的C-6位羟基，生成GlcNAc-6-P。
T75399	GlcNAc 1-P uridyltransferase (CjGlmU)
	GlcNAc 1-P uridyltransferase (CjGlmU) 为一种糖核苷酸转移酶，以UTP和GlcNAc-1-P为天然底物，负责合成UDP-GlcNAc。此酶展现出潜在的抗菌活性分子研究价值。
T37575	GLcNAc1-b-PNP	Others	Others
	GLcNAc1-b-PNP 是N-乙酰基-β-氨基葡萄糖酶的发色底物，可用于量化人血清和尿液中N-乙酰基-β-D-氨基葡萄糖酶的活性。
T75695	H-Asn(glcnac-beta-D)-OH
	H-Asn(glcnac-beta-D)-OH 是存在于尿中的内源代谢物，可用于研究 NGLY1-CDDG。
T16409	OSMI-1	Others; Acyltransferase	Metabolism; Others
	OSMI-1 是一种 O-GlcNAc 转移酶 (OGT) 抑制剂 (IC50=2.7 μM)，具有口服活性和细胞渗透性。OSMI-1 可以抑制蛋白质 O-GlcNA 酰化，而不会定性地改变细胞表面 N- 或 O- 连接的聚糖。
T78566	GlcNAcstatin
	GlcNAcstatin，一种基于葡萄糖咪唑的选择性细菌O-GlcNAcase抑制剂，其Ki值为4.6 pM，对HexA/B的选择性高出100000倍。
T61662	O-GlcNAcase-IN-4
	O-GlcNAcase-IN-4 is an inhibitor of O-GlcNAcase. It holds potential for researching neurodegenerative diseases and disorders, including Alzheimer's disease [1].
T60571	O-GlcNAcase-IN-1
	O-GlcNAcase-IN-1 是一种有效的新型 O-GlcNAcase(OGA)抑制剂，IC50值为 46 nM。
T10851	CMP-Sialic acid sodium salt CMP-Neu5Ac sodium salt	Others	Others
	CMP-Sialic acid sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. It provides a substrate for Golgi sialyltransferases. UDP-GlcNAc 2-epimerase initiates sialic acid synthesis.
T38722	(Z)-PUGNAc	Others	Others
	(Z)-PUGNAc是一种强效的O-GlcNAcase抑制剂，它比(E)-PUGNAc更有活性，能清除蛋白质上的O-GlcNAc（肽O-GlcNAc-β-N-乙酰氨基葡萄糖苷酶），并可用于增加体内核蛋白和细胞质蛋白上的O-GlcNAc水平。
T12327	OSMI-3	Others	Others
	OSMI-3 是一种高效性和细胞渗透的 O-GlcNAc 转移酶 (OGT) 抑制剂，可用于研究癌症和心血管疾病。
T67760	JNJ-65355394	Others	Others
	JNJ-65355394 是一种有效的 O-GlcNAc 水解酶 (OGA) 抑制剂，是一种 OGA 化学探针。
T12328	OSMI-4	Others	Others
	OSMI-4是一种低纳摩尔的O-GlcNAc 转移酶（OGT）抑制剂（在细胞中的EC50为3μM）,可用来研究不同人类细胞系中的OGT 抑制作用。
T16380	OGT 2115	Others	Others
	OGT 2115是一种肝素酶(IC50 = 0.4µM)抑制剂，肝素酶是一种将硫酸肝素分解成葡萄糖醛酸(GlcUA)和 n -乙酰氨基葡萄糖(GlcNAc)的酶。同时，OGT 2115也具有抗血管生成性能(IC50=1 μM)。
T9711	OGT-IN-2	Others	Others
	OGT-IN-2 是 OGT 抑制剂，抑制 sOGT 和 ncOGT 的 IC50分别为 30 μM 和 53 μM。它在关节疾病方面有研究的价值，如关节软骨疾病、骨关节炎。
T6056	Thiamet G TMG	Others; Autophagy	Autophagy; Others
	Thiamet G 是一种有效选择性O-GlcNAcase 抑制剂，抑制人 OGA 的Ki 值为 20 nM。O-GlcNAcase 的作用是从修饰的蛋白质中去除 O-GlcNAc。
T74160	UDP-glucosamine disodium
	UDP-glucosamine (UDP-GlcNAc) disodium 是一种化合物，作为O-GlcNAc转移酶的底物，负责催化O-GlcNAc与蛋白质的结合。同时，O-GlcNAc酶则负责催化从蛋白质中移除O-GlcNAc。作为己糖胺生物合成途径的终产物，UDP-glucosamine (UDP-GlcNAc) disodium主要受葡萄糖-6-磷酸-谷氨酰胺:果糖-6-磷酸氨基转移酶(GFAT)的调节。
T69343	BZX1
	BZX1 is a novel inhibitor of O-GlcNAc transferase (OGT) activity.
T63871	PG 34
	PG 34 是 OSMI-1 的结构类似物，也是 O-GlcNAc 转移酶 (OGT) 的弱抑制剂，其 IC50 值为 68 μM。
T75420	alpha-1,3/4-Fucosyltransferase (α1,3/4FucT)
	alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) (Hp3/4FT) 存在于幽门螺杆菌中。alpha-1,3/4-Fucosyltransferase (α1,3/4FucT) 催化岩藻糖从供体 GDP-β-l-岩藻糖转移到 GlcNAc。
T75400	N-Acetylhexosamine kinase (NahK)
	N-Acetylhexosamine kinase（NahK）是一种针对葡萄糖型底物的异头激酶，通过催化GlcNAc或GalNAc与ATP在异头C1位置发生磷酸化反应，生成N-乙酰己糖胺1-磷酸（GlcNAc-1P/GalNAc-1P）。
T71958	BZX2
	BZX2 is a novel inhibitor of O-GlcNAc transferase (OGT) activity.
T75412	Peptide-N-Glycosidase F (PNGaseF)
	Peptide-N-Glycosidase F (PNGaseF) 是一种天冬酰胺酰胺酶。Peptide-N-Glycosidase F 催化来自糖蛋白的高甘露糖、杂合和复杂寡糖的内层 GlcNAc 和天冬酰胺残基之间的 N-连接寡糖裂解。Peptide-N-Glycosidase F 可用于糖蛋白的结构和功能研究。
T75411	beta-1, 3-N-Acetylhexaminyltransferase (LgtA)
	Beta-1, 3-N-Acetylhexaminyltransferase (LgtA) 是一种糖基转移酶，在生化研究中常见。该酶主要催化作用为将 N-乙酰葡糖胺从 UDP-GlcNAc 转移到 N-乙酰乳糖胺和乳糖上。
T78352	N-acetylglucosamine-1-P uridyltransferase (AGX1) GlcNAc1pUT
	N-acetylglucosamine-1-P uridyltransferase (AGX1) (GlcNAc1pUT) 是具有双功能乙酰转移酶/尿苷转移酶活性的原核生物专有酶。该酶能结合GlcNAc-1-P与UTP，催化合成UDP-GlcNAc的尿苷酰转移反应。
T37567	4-Methylumbelliferyl β-D-N,N'-diacetylchitobioside
	4-Methylumbelliferyl β-D-N,N'-diacetylchitobioside (4-μU-(GlcNAc)2) is a fluorogenic substrate for chitinases and chitobiosidases. 4-μU-(GlcNAc)2 is cleaved by chitinases and chitobiosidases to release the fluorescent moiety 4-μU. 4-μU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases.
T75397	Hyaluronan synthase (PmHAS)
	Hyaluronan synthase (PmHAS)为膜蛋白，依赖Mg+2及两种糖-UDP底物（GlcUA-UDP与GlcNAc-UDP）合成HA链。该酶负责透明质酸(HA)的生物合成。
T73747	CMP-Sialic acid
	CMP-Sialic acid (CMP-Neu5Ac) 是 UDP-GlcNAc 2-epimerase 的变构抑制剂。CMP-Sialic acid 可为高尔基体唾液酸转移酶提供底物。CMP-Sialic acid 是唾液酸及其结合物的生物合成中的重要糖类核苷酸。
T74549	N-Acetyl-α-D-glucosamine 1-phosphate disodium
	N-acetyl-α-d-glucosamine 1-phosphate disodium (GlcNAc-1-P) 为异位糖磷酸盐，关键中间体于N-糖蛋白生物合成。该化合物同时作为细菌细胞壁组分磷胆酸和鼠胺的代谢前体。
T37574	4-Nitrophenyl-N-acetyl-α-D-galactosaminide
	N-acetyl-D-galactosaminidase catalyzes the cleavage of N-acetylglucosamine (GlcNAc), the monomeric unit of the polymer chitin. 4-Nitrophenyl-N-acetyl-α-D-galactosaminide can be used as a chromogenic substrate for N-acetyl-D-galactosaminidase, generating a yellow solution upon cleavage.
T71525	AB05831
	AB05831, also known as 2-Acetamido-1,2-dideoxynojirimycin, is a highly potent and specific inhibitor of beta-hexosaminidase. N-Acetyl-3-hexosaminidase (HEX) is a member of lysosomal hydrolases, which catalyzes hydrolysis of terminal, non-reducing N-acetyl-\|3-D-glucosamine (GlcNAc) andN-acetyl-(3-D-galactosamine (GalNAc) residues in glycoproteins, gan-gliosides, and glycosaminoglycans (GAGs). HEX, released by chondrocytes into the extracellular compartment, promotes cartilage matrix degradation. ...
T63988	(Rac)-OSMI-1
	(Rac)-OSMI-1 是 OSMI-1 的外消旋体。其中 OSMI-1 是 O-GlcNAc 转移酶 (OGT) 抑制剂 (IC50: 2.7 μM)。OSMI-1 对哺乳动物细胞系中的蛋白 O-连接的 N-乙酰氨基葡萄糖 (O-GlcNAcylation) 具有抑制作用，且不会定性地改变细胞表面 N-或 O-连接的聚糖。
T36577	K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt) K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)
	Histone H2B (108-125) is a peptide fragment of histone H2B that corresponds to amino acid residues 109-126 of the human histone H2B sequence. It contains an N-terminal biotinylated lysine followed by a tryptophan linker. Histone H2B can be modified by addition of an O-linked N-acetylglucosamine (GlcNAc) moiety to the serine residue at position 112, which promotes monoubiquitination of the lysine at position 120.1 Both of these modifications are associated with active transcription. Histone H2B a...

化合物

UDP-GlcNAc Disodium Salt

Cat.No: T19596

Synonym: Uridine 5′-diphospho-N-acetylglucosamine,5′-二磷酸尿嘧啶核苷-N-乙酰半乳糖胺二钠盐,UDP-α-D-N-Acetylglucosamine Disodium Salt

Target: Others

Cat.No: T9190

Synonym: GlcNAc-thiazoline,N-乙酰 - 葡糖胺基噻唑啉

Target: Others

Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH

Cat.No: T38713

Synonym: Fmoc-Asn(Ac3AcNH-beta-Glc)-OH,Fmoc-L-Asn(beta-D-GlcNAc(Ac)3)-OH

Cat.No: T83131

GlcNAc kinase (EcNagK)

Cat.No: T75405

GlcNAc 1-P uridyltransferase (CjGlmU)

Cat.No: T75399

GLcNAc1-b-PNP

Cat.No: T37575

Target: Others

H-Asn(glcnac-beta-D)-OH

Cat.No: T75695

Cat.No: T16409

Target: Others, Acyltransferase

Cat.No: T78566

O-GlcNAcase-IN-4

Cat.No: T61662

O-GlcNAcase-IN-1

Cat.No: T60571

CMP-Sialic acid sodium salt

Cat.No: T10851

Synonym: CMP-Neu5Ac sodium salt

Target: Others

Cat.No: T38722

Target: Others

Cat.No: T12327

Target: Others

Cat.No: T67760

Target: Others

Cat.No: T12328

Target: Others

Cat.No: T16380

Target: Others

Cat.No: T9711

Target: Others

Cat.No: T6056

Synonym: TMG

Target: Others, Autophagy

UDP-glucosamine disodium

Cat.No: T74160

Cat.No: T69343

Cat.No: T63871

alpha-1,3/4-Fucosyltransferase (α1,3/4FucT)

Cat.No: T75420

N-Acetylhexosamine kinase (NahK)

Cat.No: T75400

Cat.No: T71958

Peptide-N-Glycosidase F (PNGaseF)

Cat.No: T75412

beta-1, 3-N-Acetylhexaminyltransferase (LgtA)

Cat.No: T75411

N-acetylglucosamine-1-P uridyltransferase (AGX1)

Cat.No: T78352

Synonym: GlcNAc1pUT

4-Methylumbelliferyl β-D-N,N'-diacetylchitobioside

Cat.No: T37567

Hyaluronan synthase (PmHAS)

Cat.No: T75397

CMP-Sialic acid

Cat.No: T73747

N-Acetyl-α-D-glucosamine 1-phosphate disodium

Cat.No: T74549

4-Nitrophenyl-N-acetyl-α-D-galactosaminide

Cat.No: T37574

Cat.No: T71525

Cat.No: T63988

K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)

Cat.No: T36577

Synonym: K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)

Cat. No.	Product Name	Target	Signaling Pathways
T4514	N-Acetyl-D-Glucosamine N-乙酰-D-氨基葡萄糖,NAG,N-Acetyl-2-amino-2-deoxyglucose,Marine Sweet,N-Acetyl-2-amino-2-deoxy-D-glucose,N-乙酰氨基葡萄糖,GlcNAc	Endogenous Metabolite	Metabolism
	N-Acetyl-D-Glucosamine (NAG) 是葡萄糖的单糖衍生物。
T75685	UDP-3-O-acyl-GlcNAc
	UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine) 是一种E. coli 代谢产物，参与 3-deoxy-D-manno-octulosonate (KDO) 生物合成途径。
T80020	UDP-3-O-acyl-GlcNAc diammonium UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine diammonium	Endogenous Metabolite	Metabolism
	UDP-3-O-acyl-GlcNAc diammonium 是一种E. coli代谢产物，涉及3-deoxy-D-manno-octulosonate (KDO) 生物合成途径。
T13229	Tunicamycin	Influenza Virus; Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Tunicamycin 是一种抗生素的混合物，通过阻断 GlcNAc 磷酸转移酶 (GPT)，抑制 N-连接糖基化。Tunicamycin 具有抗肿瘤活性，还具有抗细菌、抗真菌和抗病毒活性。

天然产物

N-Acetyl-D-Glucosamine

Cat.No: T4514

Synonym: N-乙酰-D-氨基葡萄糖,NAG,N-Acetyl-2-amino-2-deoxyglucose,Marine Sweet,N-Acetyl-2-amino-2-deoxy-D-glucose,N-乙酰氨基葡萄糖,GlcNAc

Target: Endogenous Metabolite

UDP-3-O-acyl-GlcNAc

Cat.No: T75685

UDP-3-O-acyl-GlcNAc diammonium

Cat.No: T80020

Synonym: UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine diammonium

Target: Endogenous Metabolite

Cat.No: T13229

Target: Influenza Virus, Antibacterial, Antibiotic, Antifungal

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