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Search Results for " gas6 "

Targets Recommended: TAM Receptor

抑制剂 & 化合物

天然产物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T7425	RU-301	TAM Receptor	Tyrosine Kinase/Adaptors
	RU-301 是一种新型 pan-TAM 受体抑制剂，能够在 TAM 的 Gas6 和 Ig1 结构域之间的界面处结合发挥 pan-TAM 抑制活性，Kd=12 μM，IC50=10 μM。
T16806	RU-302 [2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]phenyl]-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone	TAM Receptor	Tyrosine Kinase/Adaptors
	RU-302 是一种 TAM 受体泛抑制剂，可阻断 TAM Ig1 胞外域和 Gas6 Lg 域之间的界面。 RU-302 有效阻断 Gas6 诱导的 AXL 的激活并抑制肺癌肿瘤的生长。
T73310	AXL-IN-14	TAM Receptor	Tyrosine Kinase/Adaptors
	AXL-IN-14为有效的口服活性AXL抑制剂，具IC50值0.8 nM。该化合物能抑制Gas6/AXL介导的细胞迁移与侵袭，并降低p-AXL与p-AKT蛋白表达，表现出抗肿瘤活性。
T76723	Tilvestamab
	Tilvestamab (BGB149) 是一种人源化抗AXL 抗体，阻断AXL 介导的细胞信号传导。Tilvestamab 在体外能显著抑制Gas6刺激诱导的AXL 激活，并抑制 786-0-Luc RCC 细胞中下游AXL 的磷酸化。Tilvestamab 可用于癌症，尤其是AXL 过度表达肾细胞癌的研究。

化合物

RU-301

Cat.No: T7425

Synonym:

Target: TAM Receptor

RU-302

Cat.No: T16806

Synonym: [2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]phenyl]-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone

Target: TAM Receptor

AXL-IN-14

Cat.No: T73310

Synonym:

Target: TAM Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T8181	Poricoic acid A Poricoic acid A(F),茯苓新酸 A	Others	Others
	Poricoic acid A (Poricoic acid A(F)) 是提取于 Poria cocos 中，拥有抗肿瘤作用。它通过调节Gas6/AxlNFκB/Nrf2 轴提高AKI-to-CKD 的褪黑激素抑制。

天然产物

Poricoic acid A

Cat.No: T8181

Synonym: Poricoic acid A(F),茯苓新酸 A

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00517	GAS6 Protein, Cynomolgus, Recombinant (His) FLJ34709,AXLLG,GAS6,DKFZp66	Cynomolgus	HEK293 Cells
	Growth arrest-specific 6, also known as Gas6, is a human gene encoding the Gas6 protein, which was originally found to be upregulated in growth-arrested fibroblasts. Gas6 is a member of the vitamin K-dependent family of proteins expressed in many human tissues and regulates several biological processes in cells, including proliferation, survival and migration, by binding to its receptors Tyro3, Axl and Mer (TAM).
TMPY-04830	GAS6 Protein, Mouse, Recombinant (His) growth arrest-specific 6,Gas-6	Mouse	HEK293 Cells
	The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation. Growth arrest-specific 6 (GAS6), plays a role in tumor...
TMPJ-00366	GAS6 Protein, Human, Recombinant (hFc) AXLLG,Gas6,GAS-6,AXLLGAX...	Human	HEK293 Cells
	GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification ...
TMPJ-00365	GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated AXLLG,Growth arrest-specific protein 6,AXL receptor...	Human	HEK293 Cells
	Human Growth arrest-specific protein 6 (GAS6) is ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, plat...
TMPY-04999	GAS6 Protein, Human, Recombinant (His)	Human	HEK293
	GAS6 (Growth arrest-specific protein 6) is also known as AXL receptor tyrosine kinase ligand, AXLLG, is a multimodular protein that is up-regulated by a wide variety of cell types in response to growth arrest. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification ...
TMPJ-01081	Dtk Protein, Human, Recombinant (His) RSE,SKY,DTK,Tyrosine-protein kinase DTK,Tyrosine-protein kin...	Human	HEK293 Cells
	Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to th...