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抑制剂 & 化合物

1

天然产物

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Cat. No. Product Name Target Signaling Pathways
T8766 GOT1 inhibitor-1

GOT1 inhibitor 2c

Others Others
GOT1 inhibitor-1 (GOT1 inhibitor 2c) 是一种新型的、非共价的谷氨酸草酰乙酸转氨酶 1 (GOT1) 抑制剂(IC50:8.2 uM),是一种戊酸衍生物。 它可用于以及胰腺导管腺癌 (PDAC) 。
T8765 iGOT1-01

Others Others
iGOT1-01 是一种天冬氨酸转氨酶 1 (谷氨酸草酰乙酸转氨酶 1GOT1) 抑制剂,在 GOT1/GLOX/HRP 测定中IC50为 11.3 μM,在 MDH 偶联 GOT1 酶法测定中IC50为 85 μM。它显示出抗癌活性。
T1093 Adapalene

CD271,阿达帕林

Apoptosis; Retinoid Receptor; Autophagy Apoptosis; Autophagy; Metabolism
Adapalene (CD271) 是一种合成类视黄醇,局部应用于痤疮。它以非竞争性方式抑制 GOT1的酶活性,具有抗肿瘤活性。它是一种 RAR 激动剂,对 RARβ、RARγ、RARα的AC50值分别为 2.3 nM、9.3 nM 和 22 nM。
T69068 Aspulvinone H

Aspulvinone H is a natural inhibitor of glutamic oxaloacetate transaminase 1 (GOT1), suppressing glutamine metabolism, making PDAC cells sensitive to oxidative stress and inhibiting cell proliferation, exhibiting potent in vivo antitumor activity in an SW1990-cell-induced xenograft model.

化合物

GOT1 inhibitor-1
Cat.No: T8766
Synonym: GOT1 inhibitor 2c
Target: Others
iGOT1-01
Cat.No: T8765
Synonym:
Target: Others
Adapalene
Cat.No: T1093
Synonym: CD271,阿达帕林
Target: Apoptosis, Retinoid Receptor, Autophagy
Aspulvinone H
Cat.No: T69068
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T36179 Aspulvinone O

Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 11.6 μM).1 Aspulvinone O inhibits aspartate transaminase 1 (GOT1; Kd = 3.32 μM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (IC50s = 20.54-26.8 μM).2 It reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Aspulvinone O (2.5 and 5 mg/kg) redu...

天然产物

Aspulvinone O
Cat.No: T36179
Synonym:
Target:
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