Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T27405 |
GAT211
AZ4,GAT-211,AZ 4,GAT 211,AZ-4 |
cAMP; Cannabinoid Receptor; Arrestin | GPCR/G Protein |
GAT211 (AZ-4) 是一种具有选择性和高效性的大麻素 1 受体 (CB1R) 正变构调节剂 (PAM),对 cAMP 和 β-arrestin2 具有较高的亲和力。GAT211 具有降眼压和抗精神病的作用,可用于研究癫痫。 | |||
T61105 |
GAT228
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GAT228 是 GAT211 的对映体,是大麻素受体 1(CB1)的配体。 | |||
T38204 |
GAT229
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GAT229 is a positive allosteric modulator of cannabinoid receptor 1 (CB1) and the S-(-) enantiomer of the CB1 modulator GAT211. It does not activate the receptor on its own but enhances the binding and activity of CB agonists. GAT229 (1 μM) enhances the binding of the CB1 full agonist CP 55,940 to CHO cells expressing human recombinant CB1 (hCB1), as well as the activity of 2-arachidonoyl glycerol , arachidonoyl ethanolamide , and CP 55,940 in arrestin2 recruitment assays and increases ERK1/2 an... |