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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7697 |
BIX-01294
|
Histone Methyltransferase; Autophagy | Autophagy; Chromatin/Epigenetic |
BIX-01294 是高度选择性的G9a 和GLP 组蛋白甲基转移酶可逆抑制剂。它通过与底物赖氨酸残基 N 端的氨基酸竞争结合来抑制 G9a/GLP,可诱导坏死性凋亡和自噬,具有抗肿瘤活性。 | |||
T1959 |
BIX-01294 trihydrochloride
BIX 01294 |
Histone Methyltransferase; Autophagy | Autophagy; Chromatin/Epigenetic |
BIX-01294 trihydrochloride 是可逆且高度选择性的G9a 和GLP 组蛋白甲基转移酶抑制剂,IC50分别为 1.9 μM 和 0.7 μM。它可诱导坏死性凋亡和自噬,具有抗肿瘤活性。它通过与底物赖氨酸残基 N 端的氨基酸竞争结合来抑制 G9a/GLP。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00907 |
GADD45A Protein, Human, Recombinant (His)
GADD45,DDIT1,Growth Arrest and DNA Damage-Inducible... |
Human | E. coli |
Growth Arrest and DNA Damage-Inducible Protein GADD45 α (GADD45A) is a member of the GADD45 family. GADD45A can be induced by UV irradiation, X-rays, growth arrest and alkylating agents, of which can be mediated by some kinases other than PKC. GADD45A can interact with MAPK14, GADD45GIP1, PCNA. In T-cells, GADD45A functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. GADD45A may affect PCNA interaction with some cell division protein kinase complexes, stimulating ... | |||
TMPY-02150 |
GADD45A Protein, Human, Recombinant (His & GST)
GADD45,growth arrest and DNA-damage-inducible, alph... |
Human | Baculovirus Insect Cells |
GADD45A is a member of the GADD45 Family, and has been found to associate with several cytoplasmic and nuclear factors and has been implicated in several cellular functions, including MAPK signaling, cell cycle regulation, DNA repair and genomic stability, apoptosis, and immune responses. The GADD45 Family of genes is rapidly induced by different stressors, including differentiation-inducing cytokines, and there is a large body of evidence that their cognate proteins are key players in cellular ... |