Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6500 |
Ferrostatin-1
Ferrostatin 1,Ferrostatin-1 (Fer-1) |
Ferroptosis; Antifungal | Apoptosis; Microbiology/Virology |
Ferrostatin-1 (Fer-1) 是一种铁死亡抑制剂,具有强效性和选择性。Ferrostatin-1 有效抑制 Erastin 诱导的 HT-1080 细胞铁死亡 (EC50=60 nM)。Ferrostatin-1 还具抗氧化和抗真菌活性。 | |||
T64167 |
Ifebemtinib
IN-10018,BI-853520 |
FAK | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Ifebemtinib (BI-853520) 是一种具有口服活性和强效性的粘附斑激酶 (FAK) 抑制剂 (IC50=1 nM),具有抗肿瘤活性,可抑制恶性胸膜间皮瘤中的球状体形成和原位肿瘤生长,可用于研究乳腺癌和卵巢癌。 | |||
T64167L |
Ifebemtinib FA
BI-853520 FA(1227948-82-4 Free base) |
FAK | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Ifebemtinib FA (BI-853520 FA) 是一种具有口服活性和高效性的粘附斑激酶 (FAK) 抑制剂,具有抗癌抗增殖活性,可用于研究卵巢癌和肺癌。 | |||
T74642 |
DB1113
|
PROTACs | PROTAC |
DB1113 (Example 24) 是一种靶向蛋白激酶降解的双功能化合物。DB1113 可降解 ABL1,ABL2,BLK,CDK11B,CDK4,CSK,EPHA3,FER,GAK,LIMK1,MAP3K20,MAP4K1,MAP4K2,MAP4K3,MAP4K5,MAPK14,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK3,NLK,PDIK1L,PTK2B,RIPK1,RPS6KA1,RPS6KA3,SIK2,SIK3,STK35,TNK2 和 ULK1。DB1113 可用于研究异常激酶活性介导的疾病或紊乱。 | |||
T74644 |
DB0614
|
PROTACs | PROTAC |
DB1113 (Example 24) 是一种靶向蛋白激酶降解的双功能化合物。DB1113 可降解ABL1,ABL2,BLK,CDK11B,CDK4,CSK,EPHA3,FER,GAK,LIMK1,MAP3K20,MAP4K1,MAP4K2,MAP4K3,MAP4K5,MAPK14,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK3,NLK,PDIK1L,PTK2B,RIPK1,RPS6KA1,RPS6KA3,SIK2,SIK3,STK35,TNK2 和ULK1。DB1113 可用于研究异常激酶活性介导的疾病或紊乱。 | |||
T36779 |
NG 25 (hydrochloride hydrate)
|
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NG 25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively).1It also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinases (IC50s = 75.2 nM), as well as CSK, FER, and p38α (IC50s = 56.4, 82.3, and 102 nM, respectively). NG 25 (100 nM) prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectiv... |