10
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2539 |
Fingolimod hydrochloride
Fingolimod (FTY720) HCl,FTY720,盐酸芬戈莫德 |
TRP/TRPV Channel; S1P Receptor; PAK; LPL Receptor | Cytoskeletal Signaling; GPCR/G Protein; Membrane transporter/Ion channel |
Fingolimod hydrochloride (FTY720) 是一种新型免疫调节剂,是一种 1-磷酸鞘氨醇(S1P) 拮抗剂,作用于 K562 和 NK 细胞,IC50为 0.033 nM。它诱导 S1P1 的内化,从而抑制 S1P 活性。它被鞘氨醇激酶磷酸化,尤其是被 SK2 磷酸化,从而可与 S1PR1、3、4 和 5 结合 | |||
T71393 |
(S)-FTY-720 Vinylphosphonate
|
||
(S)-FTY-720 Vinylphosphonate inhibits sphingosine kinase 1 and promotes its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer cells, and androgen-independent prostate cancer cells. | |||
T37548 |
azido-FTY720
azido-FTY720 |
||
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). Down-regulation of S1P1 recept... | |||
T71392 |
(R)-FTY-720 Vinylphosphonate
|
||
(R)-FTY-720 Vinylphosphonate is a sphingosine 1-phosphate type 1 (S1P1) receptor agonist and lacks anti-apoptotic activity. | |||
T31882 |
FTY720-Mitoxy
FTY 720 Mitoxy,FTY-720-Mitoxy |
||
FTY720-Mitoxy is an FTY720 analog that can be uesd as a novel stimulator of the activity of the protein phosphatase 2A (PP2A), targeting mitochondria. | |||
T20153 |
FTY720-C2
FTY 720 C 2,FTY-720-C-2 |
||
FTY720-C2 is an FTY720 analog. It acts as an effective stimulator of the activity of the protein phosphatase 2A. | |||
T15354 |
FTY720 (S)-Phosphate
(S)-FTY720 phosphate,(S)-FTY720P |
Others | Others |
FTY720 (S)-Phosphate is an S1P receptor 1 (S1PR1) agonist. It is used in the research of acute inflammatory diseases such as acute lung injury. | |||
T78091 |
(S)-FTY720-phosphonate
|
LPL Receptor | GPCR/G Protein |
FTY720 (S)-Phosphate,作为S1P受体1 (S1PR1) 激动剂,可用于研究急性肺损伤等急性炎症。 | |||
T70816 |
(R)-FTY720-OMe
|
||
(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity. | |||
T70789 |
VPC03090
|
||
VPC03090 is a Sphingosine-1-Phosphate Receptor Inhibitor. VPC03090 is an analog of FTY-720, acts as antagonist for S1PR1 and S1PR3. VPC03090-P, converted from VPC03090 through the phosphorylation by SK-2, causes a reduction in tumor growth in mice with mammary cancer, and its oral bioavailability is determined to be 30 hours. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7939 |
Fingolimod
2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇,FTY-720A,FTY-720,芬戈莫德 |
S1P Receptor; PAK; LPL Receptor | Cytoskeletal Signaling; GPCR/G Protein |
Fingolimod (FTY-720A) 是一种 1-磷酸鞘氨醇 (S1P) 拮抗剂,作用于 K562 和 NK 细胞,IC50为 0.033 nM。它还是pak1激活剂和免疫抑制剂。 |