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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1908	MHY1485	mTOR; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	MHY1485 是一种 mTOR 激活剂。它通过抑制自噬体和溶酶体之间的融合来抑制自噬过程，导致 LC3II 蛋白的积累和自噬体增大。
T76566	Fsh receptor-binding inhibitor fragment(bi-10)
	FSHreceptor-binding inhibitor fragment(bi-10) 是一种有效的 FSH 拮抗剂。FSHreceptor-binding inhibitor fragment(bi-10) 阻断 FSH 与 FSHR 的结合，并在受体水平上改变 FSH 的作用。FSHreceptor-binding inhibitor fragment(bi-10) 导致小鼠排卵抑制和卵泡闭锁。FSHreceptor-binding inhibitor fragment(bi-10) 通过下调卵巢中 FSHR 和 ERβ的过度表达来抑制卵巢癌发生。
T3630	Relugolix RVT-601,瑞卢戈利,TAK-385	GNRH Receptor	GPCR/G Protein
	Relugolix (RVT-601) 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比，它对人和猴子的受体具有高亲和力和强拮抗活性，它们的 IC50值分别为0.33 nM 和0.32 nM。它可用于研究性激素依赖性疾病，如子宫肌瘤、子宫内膜异位症、前列腺癌等。
T21308	Histrelin Supprelin LA,组氨瑞林,Histrelin Acetate	Others	Others
	Histrelin (Supprelin LA) 是促性腺激素释放激素 (GnRH) 的九肽类似物，具有增加的效力。它被认为是 GnRH 激动剂。 Histrelin 用于治疗对激素敏感的男性前列腺癌和女性子宫肌瘤。
T76222	hFSH-β-(33-53) (TFA)
	hFSH-β-(33-53) TFA 是一种含有硫醇的肽，对应于第二个 FSH 受体结合域，是 FSHR(卵泡刺激素受体) 拮抗剂。hFSH-β-(33-53) TFA 抑制 FSH 与受体的结合，是 Sertoli 细胞中雌二醇合成的部分激动剂。
T72835	FSHR agonist 1
	FSHR agonist 1是一种对卵泡刺激素(FSH)受体(FSHR)具有高亲和力并能引起变构的激动剂，具有pEC50值为7.72。它通过与TMD广泛相互作用直接激活FSHR。
TP1342L	GnRH-I acetate GnRH-I acetate(33515-09-2 free base)	Others	Others
	GnRH-I acetate 在血液中释放具有生物活性的促卵泡激素 (FSH) 和促黄体激素 (LH)。
T9380L	Antide acetate 安替肽,Antide acetate (112568-12-4 Free base)	LHRH	Endocrinology/Hormones
	Antide acetate 是一种 LHRH 拮抗剂，可抑制垂体释放 LH 和 FSH。
T5520L	Cetrorelix diacetate NS-75A,醋酸西曲瑞克,SB-075 acetate,SB-075 diacetate,Cetrorelix acetate,NS-75A diacetate	GNRH Receptor	GPCR/G Protein
	Cetrorelix diacetate (NS-75A) 是GnRH 受体的强效拮抗剂(IC50:1.21 nM)。
T21309	Nafarelin acetate(76932-56-4 free base) RS-94991-298,醋酸萘法瑞林,Nafarelin acetate,Nafarelin acetate hydrate,Synarel	GNRH Receptor	GPCR/G Protein
	Nafarelin acetate(76932-56-4 free base) (RS-94991-298) 是一种 GnRH 激动剂，可作为 GnRH 的类似物。 Nafarelin acetate(76932-56-4 free base) 导致促性腺激素促黄体激素 (LH) 和促卵泡激素 (FSH) 的垂体分泌减少。它可用于治疗雌激素依赖性病症。
T21410	Triptorelin acetate(57773-63-4 free base) 醋酸曲普瑞林,Wy 42422,Triptorelin Acetate,CL 118532,AY 25650,CL 118,532,Wy 42462,BIM 21003	GNRH Receptor	GPCR/G Protein
	Triptorelin acetate(57773-63-4 free base) (CL 118,532) 用作 GnRH 激动剂。它通过引起垂体的持续刺激来减少垂体促性腺激素促黄体激素 (LH) 和促卵泡激素 (FSH) 的分泌。曲普瑞林可用于治疗激素反应性癌症，如乳腺癌或前列腺癌、性早熟、雌激素依赖性疾病和辅助生殖。
T2597	Norgestrel 甲基炔诺酮,SH-850,FH 122-A,炔诺孕酮,WY-3707,SH-70850	Estrogen/progestogen Receptor; Reactive Oxygen Species	Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	Norgestrel (WY-3707) 是一种孕酮的合成类似物，是一种口服避孕药中常见的化合物，也是一种神经保护性强抗氧化剂，能够防止光诱导的感光细胞中的ROS 的生成以及细胞死亡。
T82307	Glp-His-Pro-Gly-NH2 pGlu-His-Pro-Gly-NH2
	pGlu-His-Pro-Gly-NH2（Glp-His-Pro-Gly-NH2）为含四氨基酸肽类化合物，可激发促性腺激素、黄体生成素（LH）与促卵泡激素（FSH）释放。
T83489	[Lys8] LH-RH
	"[Lys8] LH-RH"为LH-RH的类似物, 能够有效促进LH与FSH的释放。
T25443	FW 34569 FW-34-569,FW34569,FW 34-569,FW-34569,FW34-569
	FW 34569 is an enkephalin analogue. It stimulated growth hormones and prolactin release and inhibited the release of cortisol and LH, while FSH remained unchanged.
T76620	(D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH
	(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH 是黄体生成素释放激素 (LHRH) 的类似物。LHRH 通过刺激垂体黄体生成素 (LH) 和促卵泡激素 (FSH) 的释放，在控制生殖中发挥核心作用。
T76615	(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH
	(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH是一种LHRH(黄体生成素释放激素)的类似物，主要通过激活垂体分泌黄体生成素(LH)和促卵泡激素(FSH)来在生殖调控中发挥核心作用。
T63572	Org 43553
	Org 43553 是口服具有活力的低分子量 (LMW) 促黄体生成素受体(LH-R)激动剂，能够激动人 LH (EC50: 3.7 nM)和 FSH 受体(EC50: 110 nM) 。Org 43553 能够用于研究内分泌。
T83498	[D-Phe2,D-Ala6]-LH-RH Wy 18185
	[D-Phe2,D-Ala6]-LH-RH 为有效LH-RH拮抗剂，展现了显著的抗LH/FSH-RH及抗排卵活性。
T78515	Follicle-stimulating hormone	Others	Others
	卵泡刺激素(Follicle-stimulating hormone, FSH)为一种由垂体前叶分泌的异二聚体糖蛋白，其参与调控动物的生殖能力与繁殖效率。
T76616	(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH
	(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH 是一种黄体生成素释放激素 (LHRH) 的类似物，主要通过促进垂体分泌黄体生成素 (LH) 和促卵泡激素 (FSH) 来在生殖调控中发挥关键作用。
T81390	Prolactin-Releasing Peptide (1-31) (rat)
	Prolactin-Releasing Peptide (1-31) (rat) 通过减少禁食诱导的大鼠食物摄入，有效提升血浆LH、FSH及睾酮水平。
T82162	Human follicular gonadotropin releasing peptide hF-GRP
	Human follicular gonadotropin releasing peptide (hF-GRP)是一种刺激垂体分泌促黄体激素(LH)及促卵泡激素(FSH)的激素类多肽，其作用可在体外实现。
T68525	Nafarelin acetate hydrate
	Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estrogen/progesterone. When administered, Nafarelin has the purpose of causing increase estrogen that will negatively feed back upon hypothalamus to decrease GnRH ( negative feedback loop ) Through negative feedback, Nafarelin causes a decrease in pituitary secretion of gonadotropins lu...
T70309	Dicetrorelix pamoate
	Dicetrorelix pamoate is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently lutein...
T76048	TAK-683 acetate
	TAK-683 acetate是一种高效的KISS1R激动剂(IC50=170 pM)，改善了代谢稳定性。作为九肽metastin的类似物，对人和大鼠的EC50值分别为0.96 nM和1.6 nM。该化合物通过消耗下丘脑GnRH，能够降低血浆FSH、LH、睾酮水平，展示了对研究激素依赖性前列腺癌的潜力。
T71149	Triptorelin pamoate
	Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, es...
T68292	GTX-758
	GTX-758, also known as Capesaris, is a n orally available, nonsteroidal selective estrogen receptor (ER) alpha agonist with potential antineoplastic activity. Upon administration of GTx-758, this agent suppresses the secretion of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the pituitary gland through feedback inhibition. In males, the inhibition of LH secretion prevents the synthesis of androgens, including testosterone, by the testes. This may result in ...
T70670	TAK-448 TFA
	TAK-448 is an investigational oligopeptide analog of kisspeptin and a potent agonist of the GPR54 receptor. In animals, acute TAK-448 administration stimulates LH/FSH release, whereas continuous sc exposure rapidly down-regulates the pituitary-gonadal axis, with rapid reduction of T levels in a dose-dependent manner. TAK-448 has exhibited potent antitumor activity in rat androgen-dependent prostate cancer models. Therefore, TAK-448 may be useful in the treatment of PC in humans..
T76047	TAK-683 TFA
	TAK-683 TFA是一种高效的全KISS1R激动剂(IC50=170 pM)，拥有较好的代谢稳定性，是九肽metastin的类似物，对KISS1R有激动效应，其对人和大鼠EC50值分别为0.96 nM和1.6 nM。TAK-683 TFA能够降低下丘脑GnRH水平，进而减少血浆FSH、LH、睾酮的浓度，显示出对激素依赖性前列腺癌研究的可能性。
T81270	Ripafollitropin alfa (bovine)
	Ripafollitropin alfa (bovine)为一种结合了重组促卵泡激素(FSH)与绒毛膜促性腺激素(HCG)的融合蛋白。
T35794	Kisspeptin-54 (human) (trifluoroacetate salt)
	Kisspeptin-54 is a peptide ligand of the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors, respectively).1 It is a 54 amino acid peptide encoded by the metastasis suppressor gene KISS-1. Kisspeptin-54 induces calcium mobilization in CHO-K1 cells expressing rat and human receptors (EC50s = 1.39 and 5.47 nM, respectively). It also induces arachidonic acid release in CHO cells expressing rat and human GPR54 in a concentration-dependent manner. Kisspeptin-5...

化合物

Cat.No: T1908

Target: mTOR, Autophagy

Fsh receptor-binding inhibitor fragment(bi-10)

Cat.No: T76566

Cat.No: T3630

Synonym: RVT-601,瑞卢戈利,TAK-385

Target: GNRH Receptor

Cat.No: T21308

Synonym: Supprelin LA,组氨瑞林,Histrelin Acetate

Target: Others

hFSH-β-(33-53) (TFA)

Cat.No: T76222

FSHR agonist 1

Cat.No: T72835

Cat.No: TP1342L

Synonym: GnRH-I acetate(33515-09-2 free base)

Target: Others

Cat.No: T9380L

Synonym: 安替肽,Antide acetate (112568-12-4 Free base)

Target: LHRH

Cetrorelix diacetate

Cat.No: T5520L

Synonym: NS-75A,醋酸西曲瑞克,SB-075 acetate,SB-075 diacetate,Cetrorelix acetate,NS-75A diacetate

Target: GNRH Receptor

Nafarelin acetate(76932-56-4 free base)

Cat.No: T21309

Synonym: RS-94991-298,醋酸萘法瑞林,Nafarelin acetate,Nafarelin acetate hydrate,Synarel

Target: GNRH Receptor

Triptorelin acetate(57773-63-4 free base)

Cat.No: T21410

Synonym: 醋酸曲普瑞林,Wy 42422,Triptorelin Acetate,CL 118532,AY 25650,CL 118,532,Wy 42462,BIM 21003

Target: GNRH Receptor

Cat.No: T2597

Synonym: 甲基炔诺酮,SH-850,FH 122-A,炔诺孕酮,WY-3707,SH-70850

Target: Estrogen/progestogen Receptor, Reactive Oxygen Species

Glp-His-Pro-Gly-NH2

Cat.No: T82307

Synonym: pGlu-His-Pro-Gly-NH2

Cat.No: T83489

Cat.No: T25443

Synonym: FW-34-569,FW34569,FW 34-569,FW-34569,FW34-569

(D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH

Cat.No: T76620

(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH

Cat.No: T76615

Cat.No: T63572

[D-Phe2,D-Ala6]-LH-RH

Cat.No: T83498

Synonym: Wy 18185

Follicle-stimulating hormone

Cat.No: T78515

Target: Others

(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH

Cat.No: T76616

Prolactin-Releasing Peptide (1-31) (rat)

Cat.No: T81390

Human follicular gonadotropin releasing peptide

Cat.No: T82162

Synonym: hF-GRP

Nafarelin acetate hydrate

Cat.No: T68525

Dicetrorelix pamoate

Cat.No: T70309

TAK-683 acetate

Cat.No: T76048

Triptorelin pamoate

Cat.No: T71149

Cat.No: T68292

Cat.No: T70670

Cat.No: T76047

Ripafollitropin alfa (bovine)

Cat.No: T81270

Kisspeptin-54 (human) (trifluoroacetate salt)

Cat.No: T35794

Cat. No.	Product Name	Target	Signaling Pathways
T2S2108	Coixol 薏苡素,6-methoxybenzoxazolone,6-MBOA,6-Methoxy-2-benzoxazolinone,MBOA	Others; Antibacterial	Microbiology/Virology; Others
	Coixol (MBOA) 是一种从薏苡仁中提取的多酚，有抗菌和抗肿瘤作用。

天然产物

Cat.No: T2S2108

Synonym: 薏苡素,6-methoxybenzoxazolone,6-MBOA,6-Methoxy-2-benzoxazolinone,MBOA

Target: Others, Antibacterial

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