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Search Results for " fgf2 "

Targets Recommended: Others

11

抑制剂 & 化合物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T73133	FGF22-IN-1	Others	Others
	FGF22-IN-1 是一种潜在的 CD4 N-末端免疫球蛋白可变区样结构域（CD4 D1）抑制剂。FGF22-IN-1 可抑制CD4 与主要组织相容性复合体（MHC） II 类蛋白之间的相互作用，抑制免疫应答。
T5122	Alofanib RPT835	Apoptosis; FGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Alofanib (RPT835) 是一种高效和选择性的成纤维细胞生长因子受体2的变构抑制剂，具有抗癌和抗血管生成活性。
T24804	SM27 SM-27,NSC-37204,SM 27,NSC37204	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	SM27 是一种成纤维细胞生长因子 2（FGF2）抑制剂，具有抗血管生成活性，可用于研究肿瘤。
T26240	Surfen dihydrochloride Aminokinuride dihydrochloride,Aminoquinuride dihydrochloride,NSC-12155,Aminokinuride 2HCl,Aminoquinuride 2HCl	FGFR; Antiviral; Antibiotic	Angiogenesis; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Surfen dihydrochloride (Aminoquinuride dihydrochloride) 是一种有效的硫酸肝素小分子拮抗剂，具有抗菌和抗病毒活性，抑制炭疽致死因子、凝血因子 X 和致死因子。Surfen dihydrochloride 可抑制普通肝素和低分子量肝素的抗凝活性，抑制肝素的硫酸化和肝素裂解酶的降解。Surfen dihydrochloridn 抑制阻断硫酸乙酰肝素介导的 FGF2 结合和信号转导。Surfen 抑制 SEVI 和精液介导的 HIV 1 型感染增强。
T28939	Tec-IN-21 TecIN21,Tec IN 21,Tec Inhibitor-21
	Tec-IN-21 is an inhibitor of Tec kinase, it also blocks unconventional secretion of fibroblast growth factor 2 (FGF2).
T28940	Tec-IN-6 Tec Inhibitor-6
	Tec-IN-6 is an inhibitor of Tec kinase, it also blocks unconventional secretion of fibroblast growth factor 2 (FGF2).
T36292	NSC 12
	NSC 12 is an extracellular trap for fibroblast growth factor 2 (FGF2) that binds FGF2 (Kd = 51 μM) and interferes with its interaction with FGFR1, without affecting the ability of FGF2 to bind heparin or heparin sulfate proteoglycans (HSPGs). NSC 12 also binds several other, but not all, FGF isoforms with Kd values ranging between 16 and 120 μM, preventing them from forming HSPG/FGF/FGFR ternary complexes. NSC 12 inhibits FGF-dependent angiogenesis and tumor cell proliferation in vitro and reduc...
T23686	AHR-activator-1023 Branching Morphogenesis Modulator 1023,Cpd 1023,Compound 1023,BMM 1023
	AHR-activator-1023 is the aryl hydrocarbon receptor activator. It is also a specific FGF2-induced branching morphogenesis modulator.
T28938	Tec-IN-14 TecIN14
	Tec-IN-14 is a Tec kinase inhibitor. Tec-IN-14 blocks unconventional secretion of fibroblast growth factor 2 (FGF2).
T35807	C18 dihydro Ceramide (d18:0/18:0) C18 dihydro Ceramide (d18:0/18:0),Cer(d18:0/18:0)
	C18 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide that lacks the 4,5-trans double bond. [1] Increased C18 dihydroceramide lipid levels lead to increased triacylglycerol storage and autophagosome accumulation as well as upregulation of the fibrosis markers α-SMA and FGF2 in Chang and LX-2 liver cells. C18 dihydro Ceramide is elevated in the plasma of pre-diabetics up to 9 years prior to the onset of type 2 diabetes. [2] It is also elevated in...
TP1974	Obtustatin
	Highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitum

化合物

Cat.No: T73133

Target: Others

Cat.No: T5122

Synonym: RPT835

Target: Apoptosis, FGFR

Cat.No: T24804

Synonym: SM-27,NSC-37204,SM 27,NSC37204

Target: FGFR

Surfen dihydrochloride

Cat.No: T26240

Synonym: Aminokinuride dihydrochloride,Aminoquinuride dihydrochloride,NSC-12155,Aminokinuride 2HCl,Aminoquinuride 2HCl

Target: FGFR, Antiviral, Antibiotic

Cat.No: T28939

Synonym: TecIN21,Tec IN 21,Tec Inhibitor-21

Cat.No: T28940

Synonym: Tec Inhibitor-6

Cat.No: T36292

AHR-activator-1023

Cat.No: T23686

Synonym: Branching Morphogenesis Modulator 1023,Cpd 1023,Compound 1023,BMM 1023

Cat.No: T28938

Synonym: TecIN14

C18 dihydro Ceramide (d18:0/18:0)

Cat.No: T35807

Synonym: C18 dihydro Ceramide (d18:0/18:0),Cer(d18:0/18:0)

Cat.No: TP1974

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00842	FGF-2 Protein, Rat, Recombinant bFGF,Heparin-Binding Growth Factor 2,F...	Rat	E. coli
	FGF-basic is a members of the Fibroblast Growth Factors (FGFs) family. The family constitutes a large family of proteins involved in many aspects of development including cell proliferation, growth, and differentiation. They act on several cell types to regulate diverse physiologic functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, neurotrophic effects, and tissue repair. FGF-basic is a non-glycosylated heparin binding g...
TMPJ-00037	FGF-2 Protein, Mouse, Recombinant Fibroblast Growth Factor 2,bFGF,HBGF-2...	Mouse	E. coli
	FGF basic is one of 22 mitogenic proteins of the FGF family, which show 35-60% amino acid conservation. Unlike other FGFs, FGF acidic and basic lack signal peptides and are secreted by an alternate pathway. The 17 kDa mouse sequence has 98% aa identity with rat, and 95% identity with human, bovine, and sheep FGF basic. Binding of FGF to heparin or cell surface HSPG is necessary for binding, dimerization and activation of tyrosine kinase FGF receptors. FGF basic binds other proteins, polysacchari...
TMPJ-00039	FGF-2 Protein, Human, Recombinant (K128N) FGF2,bFGF,FGFB,Heparin-b...	Human	E. coli
	FGF-2 Protein, Human, Recombinant (K128N) is expressed in E. coli expression system. The predicted molecular weight is 17 KDa and the accession number is P09038-2.
TMPJ-00040	FGF-2 Protein, Human,Recombinant (Q65I, C96S, N111G) FGF-2,Fibroblast growth factor 2,...	Human	E. coli
	FGF-2 Protein, Human,Recombinant (Q65I, C96S, N111G) is expressed in E. coli expression system. The predicted molecular weight is 16 KDa and the accession number is P09038-2.
TMPY-00749	FGF-2 Protein, Human, Recombinant fibroblast growth factor 2 (basic),FGF-	Human	E. coli
	FGF-2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16.5 kDa and the accession number is P09038-4.
TMPH-00369	FGF-2 Protein, Chicken, Recombinant (His & Myc)	Chicken	E. coli
	Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. FGF-2 Protein, Chicken, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 23.8 kDa and the accession number is P48800.
TMPH-03203	FGFb Protein, Rabbit, Recombinant (His & SUMO)	Rabbit	E. coli
	Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation. FGFb Protein, Rabbit, Recombinant (His & SUMO) is expressed in E. coli exp...
TMPH-00368	FGF-2 Protein, Chicken, Recombinant (His)	Chicken	P. pastoris (Yeast)
	Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. FGF-2 Protein, Chicken, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 18.3 kDa and the accession number is P48800.
TMPY-01412	Glypican 5 Protein, Human, Recombinant (His) glypican 5	Human	Baculovirus Insect Cells
	Glypican-5 (GPC5), is a cell membrane protein that belongs to the glypican family. The glypicans compose a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans that may play a role in the control of cell division and growth regulation. So far, six members (Glypican-1/GPC1, Glypican-2/GPC2, Glypican-3/GPC3, Glypican-4/GPC4, Glypican-5/GPC5, Glypican-6/GPC6) of this family are known in the vertebrates. In the adult, Glypican-5 is primarily expressed in the brain. It is als...
TMPJ-01368	GPC1 Protein, Mouse, Recombinant (His) Gpc1,Glypican-1	Mouse	HEK293 Cells
	Glypican-1 is a cell membrane protein and belongs to the glypican family. The protein may act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. It is required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated sig...

重组蛋白

FGF-2 Protein, Rat, Recombinant

Cat.No: TMPJ-00842

Species: Rat

Expression System: E. coli

FGF-2 Protein, Mouse, Recombinant

Cat.No: TMPJ-00037

Species: Mouse

Expression System: E. coli

FGF-2 Protein, Human, Recombinant (K128N)

Cat.No: TMPJ-00039

Species: Human

Expression System: E. coli

FGF-2 Protein, Human,Recombinant (Q65I, C96S, N111G)

Cat.No: TMPJ-00040

Species: Human

Expression System: E. coli

FGF-2 Protein, Human, Recombinant

Cat.No: TMPY-00749

Species: Human

Expression System: E. coli

FGF-2 Protein, Chicken, Recombinant (His & Myc)

Cat.No: TMPH-00369

Species: Chicken

Expression System: E. coli

FGFb Protein, Rabbit, Recombinant (His & SUMO)

Cat.No: TMPH-03203

Species: Rabbit

Expression System: E. coli

FGF-2 Protein, Chicken, Recombinant (His)

Cat.No: TMPH-00368

Species: Chicken

Expression System: P. pastoris (Yeast)

Glypican 5 Protein, Human, Recombinant (His)

Cat.No: TMPY-01412

Species: Human

Expression System: Baculovirus Insect Cells

GPC1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01368

Species: Mouse

Expression System: HEK293 Cells

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