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抑制剂 & 化合物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T71890	F5446
	F5446 is a SUV39H1 inhibitor. F5446 has an EC50 of 0.496 μmol/L for SUV39H1 enzymatic activity. H3K9me3 was enriched in the promoters of GZMB, PRF1, FASLG, and IFNG in quiescent T cells. F5446 inhibited H3K9me3, thereby upregulating expression of these effectors in tumor-infiltrating CTLs and suppressing colon carcinoma growth in a CD8+ CTL-dependent manner in vivo. Our data indicate that SUV39H1 represses CTL effector gene expression and, in doing so, confers colon cancer immune escape.

化合物

Cat.No: T71890

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03956	Fas Ligand Protein, Human, Recombinant (His) TNLG1A,FASL,FASLG,CD178,CD95-L,APT1LG1,APTL,CD95L,F...	Human	P. pastoris (Yeast)
	Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Fas Ligand Protei...
TMPY-04587	Fas Ligand Protein, Mouse, Recombinant (His) CD178,Apt1lg1,Fasl,Cd95l,Faslg,Tnfsf6,gld,Fas ligan...	Mouse	P. pastoris (Yeast)
	Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Fas Ligand Protei...
TMPJ-00215	Fas/CD95 Protein, Mouse, Recombinant (hFc) CD95,Apoptosis-mediating surface antigen FAS,TNFRSF6,Fas,Tum...	Mouse	HEK293 Cells
	Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected in various tissues including thymus, liver, lung, heart, and adult ovary. As a receptor for TNFSF6/FASLG, The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which...
TMPY-04913	Fas Ligand Protein, Rat, Recombinant (His) Fas ligand	Rat	P. pastoris (Yeast)
	Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Fas Ligand Protei...

重组蛋白

Fas Ligand Protein, Human, Recombinant (His)

Cat.No: TMPY-03956

Species: Human

Expression System: P. pastoris (Yeast)

Fas Ligand Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04587

Species: Mouse

Expression System: P. pastoris (Yeast)

Fas/CD95 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00215

Species: Mouse

Expression System: HEK293 Cells

Fas Ligand Protein, Rat, Recombinant (His)

Cat.No: TMPY-04913

Species: Rat

Expression System: P. pastoris (Yeast)

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