Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TQ0267 |
Endomorphin 1
内吗啡肽 1,Endomorphin-1 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Endomorphin 1 是一种高亲和力和选择性的 μ-阿片受体激动剂,对 kappa3 结合位点具有合理的亲和力 ,Ki 为 20 到 30 nM 之间。 | |||
TP1251L |
N-terminally acetylated Endomorphin-1 acetate
Ac-L-Tyr-L-Pro-L-Trp-L-Phe-CONH2 |
Others | Others |
N-terminally acetylated Endomorphin-1 acetate (Ac-L-Tyr-L-Pro-L-Trp-L-Phe-CONH2) 是一种修饰的 Endomorphin-1。 | |||
TP1251 |
N-terminally acetylated Endomorphin-1
Ac-L-Tyr-L-Pro-L-Trp-L-Phe-CONH2 |
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N-terminally acetylated Endomorphin-1 is a modified Endomorphin-1. | |||
T8991 |
BMS986187
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Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
BMS986187 是一种有效的δ-阿片受体选择性正变构调节剂 (PAM),其 EC50= 0.03 μM,pKB= 6.02 (~1 μM)。BMS986187 对 μ 受体无明显 PAM 活性 (EC50=3 μM)。 | |||
T72423 |
Endomorphin 1 acetate
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Endomorphin 1 acetate,一种高度选择性的,高亲和力的μ-opioid 受体激动剂 (Ki: 1.11 nM),对 kappa3结合位点具有高亲和力,Ki 值为 20 到 30 nM 之间。Endomorphin 1 acetate 具有镇痛特性。 | |||
T26869 |
BMS-986122
BMS 986122 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
BMS-986122 (BMS 986122) 是选择性 μ 阿片受体正变构调节剂,可增加 β-抑制蛋白募集、腺苷酸环化酶抑制和 G 蛋白活化的作用,还增强 DAMGO 介导的 [35S]GTPγS 在小鼠脑膜中的结合。 | |||
T70267 |
ADL 08-0011 HCl
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ADL 08-0011 is an active metabolite of the μ-opioid receptor antagonist alvimopan. It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a μ-opioid receptor antagonist (Ki = 0.25 nM). It is selective for μ-opioid receptors over κ- and δ-opioid receptors (Kis = 15.8 and 31.6 nM, respectively). ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2 = 9.4). In vivo, ADL 08-0011 (0.03-1 mg/kg) reverse... |