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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T27189	DL-threo dihydrosphingosine DL-Safingol,DTD,DL threo dihydrosphingosine
	DL-threo dihydrosphingosine is a cell-permeable inhibitor of the extracellular signal-regulated kinase (ERK) signalling cassette in mammalian cells. DL-threo dihydrosphingosine is effective against both growth factor- and G-protein-dependent activation of
T83978	Safingol hydrochloride SPC 100270 hydrochloride,L-threo-dihydrosphingosine hydrochloride	PI3K; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) 是蛋白激酶 C 特异性抑制剂，通过抑制 PKC 和 PI3-激酶途径诱导实体瘤细胞自噬，诱导癌细胞死亡。Safingol hydrochloride 抑制 PKC 和 PI3k。
T39401	Sphinganine 1-phosphate D-erythro-Dihydrosphingosine 1-phosphate,Sphinganine 1-phosphate
	Sphinganine 1-phosphate, also known as D-erythro-Dihydrosphingosine 1-phosphate, is a polar sphingolipid metabolite. It plays a crucial role in regulating various cellular processes including cell migration, differentiation, survival, and complex physiological processes.
T37454	C16 dihydro Ceramide (d18:0/16:0) Ceramide (d18:0/16:0),Cer(d18:0/16:0),N-hexadecanoyl-D-erythro-Dihydrosphingosine,N-Palmitoyl Sphinganine
	C16 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C16 ceramide (d18:0/16:0) that lacks the 4,5-trans double bond.[1] C16 dihydro Ceramide (0-46 nM) inhibits C16 ceramide-induced membrane permeabilization, measured as cytochrome C oxidation, in rat liver mitochondria in a concentration-dependent manner. It also inhibits C16 ceramide-induced channel formation in liposomes. C16 dihydro ceramide is biologically inactive as a single agent, lacking the ability ...
T36833	A6770
	A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50= <0.01 μM), an effect that is reduced in the presence of vitamin B6(EC50= <100 μM). 1.Ohtoyo, M., Tamura, M., Machinaga, N., et al.Scintillation proximity assay to detect the changes in cellular dihydrosphingosine 1-phosphate levelsLipids51(10)1207-1216(2016)

化合物

DL-threo dihydrosphingosine

Cat.No: T27189

Synonym: DL-Safingol,DTD,DL threo dihydrosphingosine

Target:

Safingol hydrochloride

Cat.No: T83978

Synonym: SPC 100270 hydrochloride,L-threo-dihydrosphingosine hydrochloride

Target: PI3K, PKC

Sphinganine 1-phosphate

Cat.No: T39401

Synonym: D-erythro-Dihydrosphingosine 1-phosphate,Sphinganine 1-phosphate

Target:

C16 dihydro Ceramide (d18:0/16:0)

Cat.No: T37454

Synonym: Ceramide (d18:0/16:0),Cer(d18:0/16:0),N-hexadecanoyl-D-erythro-Dihydrosphingosine,N-Palmitoyl Sphinganine

Cat. No.	Product Name	Target	Signaling Pathways
T22723	Dihydrosphingosine	Others	Others
	Dihydrosphingosine is a Protein kinase C inhibitor.
T13632	D-Erythro-dihydrosphingosine Dihydrosphingosine,Octadecasphinganine,D-赤式-C 18 - 二氢-D-神经鞘氨醇,C18-Dihydrosphingosine,D-erythro-Sphinganine	Phospholipase; Endogenous Metabolite	Metabolism
	D-Erythro-dihydrosphingosine (C18-Dihydrosphingosine) 可抑制花生四烯酸的释放和cPLA2α活性。