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3

抑制剂 & 化合物

2

天然产物

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Cat. No. Product Name Target Signaling Pathways
T4681 T863

DGAT-3,DGAT-1 inhibitor

Acyltransferase; Transferase Metabolism
T863 (DGAT-3) 是口服有效的二酰基甘油酰基转移酶1 选择性抑制剂。T863结合DGAT1的酰基辅酶A 结合位点,抑制三酰甘油在细胞内的合成。
T62220 DGAT1-IN-3

DGAT1-IN-3 是一种选择性的、有效的,口服具有活力的 DGAT-1 抑制剂,能够抑制人类 DGAT-1 (IC50: 38 nM) 和大鼠 DGAT-1 (IC50: 120 nM)。DGAT1-IN-3 能够用于肥胖、血脂异常和代谢综合征的研究。
T11491 GSK2973980A

Transferase Metabolism
GSK2973980A is a selective Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitor (IC50: 3 nM).

化合物

T863
Cat.No: T4681
Synonym: DGAT-3,DGAT-1 inhibitor
Target: Acyltransferase, Transferase
DGAT1-IN-3
Cat.No: T62220
Synonym:
Target:
GSK2973980A
Cat.No: T11491
Synonym:
Target: Transferase
Cat. No. Product Name Target Signaling Pathways
TN3255 7beta-(3-Ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone

Others Others
7beta-(3-Ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone shows diacylglycerol acyltransferase (DGAT)1 inhibition with IC(50) values of 47.0 microM (for rat liver microsomes) and 160.7 microM (for HepG2 cell microsomes),
T37690 Phenylpyropene A

Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM).1 Phenylpyropene A inhibits diacylglycerol acyltransferase (DGAT) in rat liver microsomes (IC50 = 78.7 μM). It induces mortality in 100% of M. persicae when used at a concentration of 5 ppm.3 |1. Kwon, O.E., Rho, M.C., Song, H.Y., et al. Phenylpyropene A and B, new inhibitors of ...

天然产物

7beta-(3-Ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone
Cat.No: TN3255
Synonym:
Target: Others
Phenylpyropene A
Cat.No: T37690
Synonym:
Target:
TargetMol Loading
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