Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10924 |
Cysteine protease inhibitor-2
|
Cysteine Protease | Proteases/Proteasome |
Cysteine protease inhibitor-2 是半胱氨酸蛋白酶抑制剂。 | |||
T7451 |
2-Cyanopyrimidine
2-氰基嘧啶,2-cyano-Pyrimidine |
Cysteine Protease | Proteases/Proteasome |
2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) 是半胱氨酸蛋白酶组织蛋白酶 K (cysteine protease cathepsin K) 的非选择性抑制剂(IC50:170 nM)。它能够用于骨质疏松症的研究。 | |||
T9458 |
PF-00835231
|
SARS-CoV | Microbiology/Virology |
PF-00835231 是一种 CoV-2 半胱氨酸 3C 样蛋白酶抑制剂,对 SARS CoV-2 和 SARS CoV-1 3CLpro 的 IC50 分别为 0.27 nM 和 4 nM。它用于抗 SARS-CoV-2/COVID-19 的研究。 | |||
T80542 |
Z-Leu-Leu-Leu-fluoromethyl ketone
Z-LLL-FMK |
||
Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK)为半胱氨酸蛋白酶抑制剂,可抑制SARS感染,并能保护小鼠免遭T. crassiceps侵害。 | |||
T63760 |
3CPLro-IN-2
|
||
3CPLro-IN-2 是有效的、口服具有活力的 SARS-CoV-2 3CLpro 抑制剂 (IC50: 1.55 μM, Ki: 6.09 μM)。3-糜蛋白酶样半胱氨酸蛋白酶 (3CLpro) 是病毒复制中不可或缺的蛋白质,是有潜力的对抗 COVID-19 的药物靶点。 | |||
T64159 |
Cathepsin K inhibitor 2
|
||
Cathepsin K inhibitor 2 是一种 cathepsin K 的有效抑制剂。其中 Cathepsin K (Cat K) 是一种半胱氨酸蛋白酶,在 CTSK 基因调控下表达,与骨质疏松症密切相关,能够水解胶原蛋白。Cathepsin K inhibitor 2 对骨关节炎表现出研究潜力。 | |||
T63537 |
SARS-CoV-2 3CLpro-IN-1
|
||
SARS-CoV-2 3CLpro-IN-1 (Compound 14c) is a highly potent inhibitor specifically designed to target and inhibit the activity of SARS-CoV-2 3CL pro, which is a cysteine-protease found in the main coronaviruses. This particular enzyme has been recognized as a highly promising target for the development of effective antiviral drugs. Therefore, SARS-CoV-2 3CLpro-IN-1 holds significant potential for advancing research and development in the field of infectious diseases [1]. | |||
T62479 |
3CPLro-IN-1
|
||
3CPLro-IN-1 (compound A17) 是一种有效的、口服具有活力的 SARS-CoV-2 3CLpro 抑制剂 (IC50: 5.65 μM)。3-糜蛋白酶样半胱氨酸蛋白酶 (3CLpro) 是一种病毒复制中不可或缺的蛋白质,是一种有吸引力的、对抗 COVID-19 的药物靶点。 | |||
T78119 |
Z-L(D-Val)G-CHN2
|
HSV | Microbiology/Virology |
Z-L(D-Val)G-CHN2(即Z-LVG-CHN2)是半胱氨酸蛋白酶抑制剂的异构体,作为一种三肽衍生物,模仿了人体半胱氨酸蛋白酶结合中心的部分结构。它可以抑制HSV,并且能有效阻断SARS-COV-2的3CL pro蛋白酶,从而抑制病毒活性(EC50=190 nM),但对脊髓灰质炎病毒复制无显著作用。 | |||
T35802 |
ML-345
|
||
Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. [1] In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer's disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM. [2] It de... |