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Search Results for " ctgf "

Targets Recommended: p38 MAPK Casein Kinase JNK

6

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T6150	TAK-715	p38 MAPK; Casein Kinase; JNK	MAPK; Metabolism; Stem Cells
	TAK-715 是一种具有口服活性的p38 MAPK 抑制剂，对 p38α 和 p38β 的IC50分别为 7.1 nM 和200 nM。它抑制酪蛋白激酶 I (CK1δ/ε)，调节 Wnt/β-catenin 信号传导的激活，有抗炎活性。
T28222	5-Hydroxy-1-methylhydantoin HD-003,HD003,5-羟基-1-甲基咪唑啉-2,4-二酮,NZ419,NZ-419,HD 003,NZ 419	Bradykinin Receptor	GPCR/G Protein
	5-Hydroxy-1-methylhydantoin (HD-003) 是一种可能用于治疗肾衰竭的抗氧化剂。它是肌酐代谢物，是一种羟基自由基清除剂，此前已显示通过抑制大鼠慢性肾病的进展来提供肾脏保护。它是一种新型抗氧化药物，可完全抑制 B2-激肽受体(B2KR) 对 VSMC 中高葡萄糖 (25 mM) 刺激的反应，并且还显示可减弱 BK 对 VSMC 重塑的影响。它抑制 BK 诱导的 MAPK 磷酸化增加并减弱 VSMC 中结缔组织生长因子 (CTGF) 蛋白水平的增加。这些研究结果表明，它可能通过其抗氧化特性赋予血管保护免受高葡萄糖浓度和 BK 刺激以改善血管损伤和重塑。
T79427	LM-41	YAP	Stem Cells
	LM-41是一种衍生自Flufenamic acid的TEAD抑制剂，能有效下调CTGF、Cyr61、Axl和NF2的表达水平。此外，LM-41抑制了人类MDA-MB-231乳腺癌细胞的迁移。
T76804	FG-3019
	FG-3019 (Pamrevlumab)为重组人源化抗体，特异性结合于结缔组织生长因子(CTGF)。适用于特发性肺纤维化(IPF)研究领域。
T82766	CCG-232964	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	CCG-232964为口服活性Rho/MRTF/SRF抑制剂，能够抑制LPA诱导的CTGF基因表达。
T79428	AF-2112	YAP	Stem Cells
	AF-2112为Flufenamic acid衍生物，作为TEAD抑制剂，能显著抑制CTGF、Cyr61、Axl及NF2基因表达。

化合物

Cat.No: T6150

Target: p38 MAPK, Casein Kinase, JNK

5-Hydroxy-1-methylhydantoin

Cat.No: T28222

Synonym: HD-003,HD003,5-羟基-1-甲基咪唑啉-2,4-二酮,NZ419,NZ-419,HD 003,NZ 419

Target: Bradykinin Receptor

Cat.No: T79427

Target: YAP

Cat.No: T76804

Cat.No: T82766

Target: ROCK

Cat.No: T79428

Target: YAP

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01163	CTGF/CCN2 Protein, Human, Recombinant (HEK293, His) CTGF,Connective tissue growth factor	Human	HEK293 Cells
	Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CYR61/CTGF/NOV) family of secreted matricellular proteins. Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain. CTGF has various biological functions, including cell adhesion, migration, proliferation, differentiation, and ECM production, and participates in the development of many organs under normal physio...
TMPK-00672	CTGF/CCN2 Protein, Rhesus macaque, Recombinant (His) CTGRP,CTGF,IBP-8,CCN2,NOV2,HCS24,IGFBP8,Fisp12	Rhesus	HEK293 Cells
	Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other growth factors and promotes kidney fibrosis.CTGF can simultaneously interact with several factors with its four domains. The microenvironment differs depending on the types of cells and tissues and differentiation stages of these cells. CTGF/CCN2 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His ta...
TMPK-01000	CTGF/CCN2 Protein, Human, Recombinant (His & Avi), Biotinylated CTGF,CCN2,IBP-8,IGFBP8,Fisp12,CTGRP,HCS24,MGC102839...	Human	HEK293 Cells
	Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other growth factors and promotes kidney fibrosis.CTGF can simultaneously interact with several factors with its four domains. The microenvironment differs depending on the types of cells and tissues and differentiation stages of these cells. CTGF/CCN2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells wi...
TMPJ-01162	CTGF/CCN2 Protein, Human, Recombinant (hFc) IGFBP8,Connective tissue growth factor,Hypertrophic chondroc...	Human	HEK293 Cells
	CTGF/CCN2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 67-81 KDa and the accession number is Q5M8T4.
TMPH-02568	CTGF/CCN2 Protein, Mouse, Recombinant (GST) betaIG-M2,Connective tissue growth factor,Protein FISP-12,Fi...	Mouse	E. coli
	Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
TMPH-01069	CTGF/CCN2 Protein, Human, Recombinant (His) Hypertrophic chondrocyte-specific protein 24,CCN family memb...	Human	E. coli
	Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. CTGF/CCN2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 15.1 kDa and...
TMPJ-01161	CTGF/CCN2 Protein, Human, Recombinant IGFBP-8,CCN family member 2,IBP-8,Connective tissue growth f...	Human	HEK293 Cells
	CTGF/CCN2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 16-25 KDa and the accession number is Q5M8T4.
TMPY-00950	WISP1/CCN4 Protein, Human, Recombinant (His) WISP1c,WISP1i,CCN4,WNT1 inducible signaling pathway protein ...	Human	HEK293 Cells
	CCN4/Wnt-induced secreted protein 1 (WISP1) is a secreted, cysteine-rich, heparin-binding glycoprotein, belonging to the CCN (CTGF/CYR61/NOV) family of growth factors, and is involved in diverse biological functions such as cell growth, adhesion, migration, angiogenesis, tissue repair, and regulation of extracellular matrix. Members of the CCN family demonstrate high structural homology sharing four conserved cysteine-rich modular domains: an IGFBP (insulin-like growth factor-binding) domain, a ...

重组蛋白

CTGF/CCN2 Protein, Human, Recombinant (HEK293, His)

Cat.No: TMPJ-01163

Species: Human

Expression System: HEK293 Cells

CTGF/CCN2 Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPK-00672

Species: Rhesus

Expression System: HEK293 Cells

CTGF/CCN2 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01000

Species: Human

Expression System: HEK293 Cells

CTGF/CCN2 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-01162

Species: Human

Expression System: HEK293 Cells

CTGF/CCN2 Protein, Mouse, Recombinant (GST)

Cat.No: TMPH-02568

Species: Mouse

Expression System: E. coli

CTGF/CCN2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01069

Species: Human

Expression System: E. coli

CTGF/CCN2 Protein, Human, Recombinant

Cat.No: TMPJ-01161

Species: Human

Expression System: HEK293 Cells

WISP1/CCN4 Protein, Human, Recombinant (His)

Cat.No: TMPY-00950

Species: Human

Expression System: HEK293 Cells

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