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Search Results for " chromatin/epigenetic "

Targets Recommended: Epigenetic Reader Domain

4

抑制剂 & 化合物

3

化合物库

8

重组蛋白

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Cat. No.	Product Name
L8300	染色质修饰分子库		256 compounds
	256 种染色质化学修饰相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L1200	表观遗传库		960 compounds
	960 种表观遗传学研究相关的生物活性小分子的特有集合，用于表观遗传学研究及其相关的检测和高通量、高内涵筛选；
L3500	组蛋白修饰化合物库		480 compounds
	480 个组蛋白修饰相关的小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

染色质修饰分子库

Cat.No: L8300

Compounds: 256

表观遗传库

Cat.No: L1200

Compounds: 960

组蛋白修饰化合物库

Cat.No: L3500

Compounds: 480

Cat. No.	Product Name	Target	Signaling Pathways
T5443	JQ-1 (carboxylic acid) JQ-1 carboxylic acid	Epigenetic Reader Domain	Chromatin/Epigenetic
	JQ-1 (carboxylic acid) 是一种细胞渗透性 BRD4 抑制剂，对 BRD4(1) 和 BRD4(2) 的 IC50 分别为 77 和 33 nM。它是一种 (+)-JQ1 衍生物，可作为合成 PROTACs 的前体。
T15784	LP99	Epigenetic Reader Domain	Chromatin/Epigenetic
	LP99 是一种表观遗传探针，可破坏 BRD7 和 BRD9 与细胞中染色质的结合。它是一种选择性的 BRD7 和 BRD9 溴结构域抑制剂，对 BRD9 的 Kd 为 99 nM。
T39810	CEM114
	CEM114 is a potent chemical compound known as a chemical epigenetic modifier (CEM). It functions by employing CRISPR-Cas9 systems to harness endogenous chromatin machinery, thereby exerting its epigenetic modifying effects.
T72013	Epigenetic Multiple Ligand
	Epigenetic Multiple Ligand is a cell-permeable inhibitor of substrate processing by several chromatin-associated enzymes, including SIRT1/2, H3/SET7, H3/p300/CBP, H4/RmtA, PABP1/CARM1, and H4/PRMT1. It acts by inducing either apoptosis or granulocytic differentiation.

化合物

JQ-1 (carboxylic acid)

Cat.No: T5443

Synonym: JQ-1 carboxylic acid

Target: Epigenetic Reader Domain

Cat.No: T15784

Target: Epigenetic Reader Domain

Cat.No: T39810

Epigenetic Multiple Ligand

Cat.No: T72013

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01478	HSP90 alpha Protein, Human, Recombinant Hsp89,Hsp90,HSPCAL1,heat shock protein 90kDa alpha (cytosoli...	Human	E. coli
	Heat shock protein 90 (90 kDa heat-shock protein, HSP90) is a molecular chaperone involved in the trafficking of proteins in the cell. It is a remarkably versatile protein involved in the stress response and normal homoeostatic control mechanisms. HSP90 interacts with 'client proteins', including protein kinases, transcription factors, and others, and either facilitates their stabilization and activation or directs them for proteasomal degradation. By this means, HSP90 displays a multifaceted ab...
TMPJ-00694	BRD4 Protein, Human, Recombinant (His & Flag) MCAP,HUNK1,HUNKI,bromodomain-containing protein 4	Human	E. coli
	Bromodomain-containing protein 4 (BRD4) is a member of the BET class chromatin reader proteins that bind acetylated histones and play a key role in transcriptional regulation and transmission of epigenetic memory. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. BRD bromodomains serve as recognition motifs for ...
TMPJ-00986	CTCF Protein, Human, Recombinant Transcriptional Repressor CTCF,CCCTC-Binding Factor,CTCFL Pa...	Human	E. coli
	Transcriptional Repressor CTCF (CTCF) belongs to the CTCF Zinc-Finger Protein family. CTCF contains twelve C2H2-type zinc fingers and interacts with CHD8. CTCF is widely expressed in many tissues, and it is absent in primary spermatocytes. CTCF is involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. CTCF plays an essential role in oocyte and preimplantation embryo development by activating or rep...
TMPH-01088	CBX5 Protein, Human, Recombinant (His & Myc) HP1 alpha,CBX5,Heterochromatin protein 1 homolog al...	Human	E. coli
	Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
TMPY-02957	DYDC2 Protein, Human, Recombinant (GST) DPY30 domain containing 2	Human	E. coli
	DPY30 domain containing 2 belongs to the dpy-30 family. Dumpy-30 family members act as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila. MTF-1 plays a key role in transition metal detoxification and homeostasis. It binds to metal response elements (MREs). Two candidate dMTF-1 interactors are related to the small regulatory protein Dumpy-30 (Dpy-30) of the worm C. elegans. Dpy-30 is the founding member of a protein family inv...
TMPY-02979	HMGN3 Protein, Human, Recombinant (His) PNAS-24,TRIP7,PNAS-25,high mobility group nucleosomal bindin...	Human	E. coli
	HMGN3 belongs to the HMGN family and is expressed in the kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate, and uterus. Members of the HMGN family bind to nucleosomes without any specificity for the underlying DNA sequence. They affect the global and local structure of chromatin, as well as the levels of histone modifications, and thus play a role in epigenetic regulation of gene expression. HMGN3 regulates the expression of the glucose transporter ...
TMPY-06846	HSP90 alpha Protein, Mouse, Recombinant (His) AL024080,Hspca,hsp4,Hsp86-1,heat shock protein 90kDa α (cyto...	Mouse	Baculovirus-Insect Cells
	Heat shock protein 90 (90 kDa heat-shock protein, HSP90) is a molecular chaperone involved in the trafficking of proteins in the cell. It is a remarkably versatile protein involved in the stress response and normal homoeostatic control mechanisms. HSP90 interacts with 'client proteins', including protein kinases, transcription factors, and others, and either facilitates their stabilization and activation or directs them for proteasomal degradation. By this means, HSP90 displays a multifaceted ab...
TMPY-06845	HSP90 alpha Protein, Human, Recombinant (His) EL52,HSP89A,heat shock protein 90kDa alpha (cytosolic), clas...	Human	Baculovirus-Insect Cells
	Heat shock protein 90 (90 kDa heat-shock protein, HSP90) is a molecular chaperone involved in the trafficking of proteins in the cell. It is a remarkably versatile protein involved in the stress response and normal homoeostatic control mechanisms. HSP90 interacts with 'client proteins', including protein kinases, transcription factors, and others, and either facilitates their stabilization and activation or directs them for proteasomal degradation. By this means, HSP90 displays a multifaceted ab...

重组蛋白

HSP90 alpha Protein, Human, Recombinant

Cat.No: TMPY-01478

Species: Human

Expression System: E. coli

BRD4 Protein, Human, Recombinant (His & Flag)

Cat.No: TMPJ-00694

Species: Human

Expression System: E. coli

CTCF Protein, Human, Recombinant

Cat.No: TMPJ-00986

Species: Human

Expression System: E. coli

CBX5 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01088

Species: Human

Expression System: E. coli

DYDC2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02957

Species: Human

Expression System: E. coli

HMGN3 Protein, Human, Recombinant (His)

Cat.No: TMPY-02979

Species: Human

Expression System: E. coli

HSP90 alpha Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06846

Species: Mouse

Expression System: Baculovirus-Insect Cells

HSP90 alpha Protein, Human, Recombinant (His)

Cat.No: TMPY-06845

Species: Human

Expression System: Baculovirus-Insect Cells

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