Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7753 |
Thalidomide-O-COOH
Cereblon ligand 3,E3 ligase Ligand 3,TCE35031 |
Others; Ligand for E3 Ligase | Others; PROTAC |
Thalidomide-O-COOH (Cereblon ligand 3) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。 | |||
T7758 |
Thalidomide-O-amido-PEG3-C2-NH2 TFA
E3 ligase Ligand-Linker Conjugates 14 TFA,Cereblon Ligand-Linker Conjugates 3 (TFA) |
Others; E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase | Others; PROTAC |
Thalidomide-O-amido-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 3 (TFA)) 包含基于 Thalidomide 的 cereblon 配体和 3 个单元的 PEG linker,是一种合成的 E3 连接酶配体-linker 偶联物。 | |||
T7760 |
Thalidomide-O-amido-C3-NH2 TFA
Cereblon Ligand-Linker Conjugates 16 TFA,E3 Ligase Ligand-Linker Conjugates 52 TFA |
E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase | PROTAC |
Thalidomide-O-amido-C3-NH2 TFA (Cereblon Ligand-Linker Conjugates 16 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物,。 | |||
T7755 |
Thalidomide 4-fluoride
E3 ligase Ligand 4,2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮 |
IRAK; Ligand for E3 Ligase | Immunology/Inflammation; NF-κB; PROTAC |
Thalidomide 4-fluoride (E3 ligase Ligand 4) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与 IRAK4 靶蛋白配体连接,得到 PROTAC IRAK4 degrader-1。 | |||
T9809 |
E3 ligase Ligand 23
|
Ligand for E3 Ligase | PROTAC |
E3 ligase Ligand 23 是一种 cereblon 结合剂,可通过泛素蛋白酶体降解 Ikaros 或 Aiolos。 | |||
T17915 |
Thalidomide-O-amido-PEG3-C2-NH2
Cereblon Ligand-Linker Conjugates 3,E3 Ligase Ligand-Linker Conjugates 14 |
Others | Others |
Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) is an E3 ligase ligand-linker conjugate which is designed using Thalidomide-based cereblon ligand and a 3-unit PEG linker. This compound is synthesized specifically for utilization in PROTAC technology. | |||
T18553 |
Pomalidomide-amido-PEG3-C2-NH2
Cereblon Ligand-Linker Conjugates 22,E3 ligase Ligand-Linker Conjugates 55 |
Others | Others |
Pomalidomide-amido-PEG3-C2-NH2, known as Cereblon Ligand-Linker Conjugates 22, is a synthesized E3 ligase ligand-linker conjugate designed for use in PROTAC technology. It consists of the Pomalidomide-based cereblon ligand and a 3-unit PEG linker. [1] | |||
T17914 |
Thalidomide-O-amido-C3-COOH
Cereblon Ligand-Linker Conjugates 7,E3 ligase Ligand-Linker Conjugates 15 |
Others | Others |
Thalidomide-O-amido-C3-COOH is a synthesized conjugate of an E3 ligase ligand-linker compound that combines a cereblon ligand derived from Thalidomide with a linker commonly employed in PROTAC technology. | |||
T17883 |
Pomalidomide-PEG3-C2-NH2
Cereblon Ligand-Linker Conjugates 5,E3 ligase Ligand-Linker Conjugates 30 |
Others; PROTAC Linker | Others; PROTAC |
Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) 是一种合成的 E3 连接酶配体-linker 偶联物,包含基于 Pomalidomide 的 cereblon 配体和 3 单元 PEG 的linker。 | |||
T17875 |
Pomalidomide-C2-NH2
Cereblon Ligand-Linker Conjugates 15,4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione |
Others; Ligand for E3 Ligase | Others; PROTAC |
Pomalidomide-C2-NH2 (4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) 包含基于 Pomalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物,。 | |||
T39426 |
Thalidomide-O-amido-C3-NH2
Thalidomide-O-amido-C3-NH2,Cereblon Ligand-Linker Conjugates 16,E3LigaseLigand-LinkerConjugates52 |
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Thalidomide-O-amido-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate, which combines the cereblon ligand derived from Thalidomide with a linker utilized in PROTAC technology. | |||
T40105 |
Pomalidomide-PEG3-C2-NH2 hydrochloride
Pomalidomide-PEG3-C2-NH2 hydrochloride,Cereblon Ligand-Linker Conjugates 5 hydrochloride,E3ligaseLigand-LinkerConjugates30hydrochloride |
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Pomalidomide-PEG3-C2-NH2 hydrochloride, also known as Cereblon Ligand-Linker Conjugate 5, is a chemically synthesized E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand based on Pomalidomide and a linker commonly employed in PROTAC technology. | |||
T17882 |
Pomalidomide-PEG3-C2-NH2 (TFA)
Cereblon Ligand-Linker Conjugates 5 (TFA),E3 ligase Ligand-Linker Conjugates 30 (TFA),Pomalidomide-PEG3-C2-NH2 (TFA) (2093416-31-8 free base) |
Others | Others |
Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. | |||
T40023 |
Pomalidomide-PEG3-CO2H
Thalidomide-NH-PEG3-propionic acid |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Pomalidomide-PEG3-CO2H (Thalidomide-NH-PEG3-propionic acid) 是一种由 E3 连接酶配体和连接体组成的偶联物,结合了基于 Thalidomide 的 Cereblon 配体和 3 个单元 PEG Linker。 | |||
T40016 |
Thalidomide-NH-CH2-COOH
2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetic acid,(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine |
Ligand for E3 Ligase | PROTAC |
Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) 是一种基于 Thalidomide 的 Cereblon 配体,可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。 | |||
T9291 |
Thalidomide-5-OH
4 - 羟基沙利度胺,2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione |
Others; Ligand for E3 Ligase | Others; PROTAC |
Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) 是基于 Thalidomide 的的cereblon 配体,可用于募集CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接,得到 PROTAC 分子。 | |||
T9381 |
Thalidomide 5-fluoride
2-(2,6-二氧代 - 哌啶-3-基)-5-氟 - 异吲哚-1,3-二酮,H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro- |
Ligand for E3 Ligase | PROTAC |
Thalidomide 5-fluoride (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-) 是一种基于沙利度胺的 Cereblon 配体,通过 linker 与 IRAK4 蛋白配体结合形成 PROTACIRAK4 degrader-1。 | |||
T9401 |
Thalidomide-NH-PEG1-NH2 hydrochloride
4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-NH-PEG1-NH2 hydrochloride (4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是合成的 E3 连接酶配体-linker 偶联物,可用于 PROTAC 的合成。 | |||
T40026 |
Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-
4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid |
Others | Others |
Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- (4-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]butanoic acid)可用于后续化学的带有烷基接头和末端酸的 Cereblon 配体。 | |||
T9382 |
Thalidomide-NH-C2-PEG3-OH
H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- |
E3 Ligase Ligand-Linker Conjugate | PROTAC |
Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是 E3 连接酶配体-linker 偶联物,可用于合成 PROTAC BCL-XL 降解剂 XZ739。 | |||
T39804 |
Pomalidomide-PEG3-azide
Pomalidomide-PEG3-azide |
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Pomalidomide-PEG3-azide is a chemically synthesized conjugate comprised of a cereblon ligand based on Pomalidomide, an E3 ligase ligand-linker, and a 3-unit PEG linker. This conjugate is specifically designed for use in PROTAC technology. | |||
T77918 |
Thalidomide-O-C8-COOH
|
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Thalidomide-O-C8-COOH,一种Thalidomide衍生的Cereblon配体,能有效募集CRBN蛋白。通过linker,Thalidomide-O-C8-COOH可与靶蛋白配体结合,构建PROTAC分子。 | |||
T60251 |
GID4 Ligand 3
|
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GID4 Ligand 3 (compound 16) 是GID4的结合物,体外Kd 值为 110 μM,IC50值为 148.5 μM。GID4 Ligand 3 可用于 cereblon(CRBN) 和Von Hippel-Lindau(VHL)的相关研究。 | |||
T17917 |
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2
E3 Ligase Ligand-Linker Conjugates 23 TFA,Cereblon Ligand-Linker Conjugates 12 TFA |
Others | Others |
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized conjugate compound known as an E3 ligase ligand-linker. It incorporates a cereblon ligand based on Thalidomide and a 3-unit PEG linker. This compound is specifically designed for use in PROTAC technology applications. | |||
T39215 |
Thalidomide-O-amido-C3-PEG3-C1-NH2
Thalidomide-O-amido-C3-PEG3-C1-NH2 |
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Thalidomide-O-amido-C3-PEG3-C1-NH2 is a synthesized conjugate compound that serves as an E3 ligase ligand-linker. It features a cereblon ligand based on Thalidomide and a 3-unit PEG linker. This compound is specifically designed for use in PROTAC technology. | |||
T18068 |
Lenalidomide-PEG3-iodine
|
Others | Others |
Lenalidomide-PEG3-iodine, an E3 ligase ligand-linker conjugate, consists of a cereblon-based Lenalidomide ligand and a 3-unit polyethylene glycol (PEG) linker. This compound is utilized in creating various proteolysis targeting chimeras (PROTACs), including the highly effective PROTAC BTK degrader SJF620, which has a degradation concentration 50 (DC50) of 7.9 nM[1]. | |||
T18820 |
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride
|
Others | Others |
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a chemical compound that has been synthesized as an E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand derived from Thalidomide and a 3-unit PEG linker. It is specifically designed for use in PROTAC technology, which utilizes small molecules to induce protein degradation [1]. | |||
T39806 |
Pomalidomide 4'-PEG3-azide
Pomalidomide 4'-PEG3-azide |
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Pomalidomide 4'-PEG3-azide is a chemically synthesized conjugate consisting of an E3 ligase ligand-linker conjugate that incorporates the cereblon ligand derived from Pomalidomide, along with a linker. This compound, Pomalidomide 4'-PEG3-azide, is utilized in the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3, developed through the PROTAC strategy, is an effective degrader of PARP1, derived from Rucaparib. | |||
T74429 |
SJ10542
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SJ10542 是一种有效的选择性 JAK2/3导向苯基戊二酰亚胺 (PG)-PROTAC,对 JAK2、JAK3 和 JAK2-fusion ALL 的 DC50分别为 14、11 和 24 nM。SJ10542 利用 PG 配体作为cereblon(CRBN) 招募剂。 | |||
T41164 |
FC 11
|
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FC 11 is a highly potent focal adhesion Ki nase (FAK) PROTAC®Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon-binding ligand Pomalidomide. The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells. |