首页工具

登录

搜索结果

Search Results for " cyslt1 "

Targets Recommended: Others

16

抑制剂 & 化合物

1

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T11388	Gemilukast ONO-6950	Others	Others
	Gemilukast（ONO-6950）是一种具有口服活性和有效性的半胱氨酰白三烯 1 和 2 受体 (CysLT1 和CysLT2) 双重抑制剂，抑制 LTC 4 诱导的支气管收缩，对人 CysLT1 和 CysLT2 有抑制作用，可用于治疗哮喘。
T7841	MK 571 MK-571钠盐,L660711,L-660711,MK-571	LTR	Immunology/Inflammation
	MK 571 (L660711) 是一种具有口服活性的 CysLT1 受体拮抗剂。
T3148	MK-571 sodium L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid	Leukotriene Receptor; LTR	GPCR/G Protein; Immunology/Inflammation
	MK-571 sodium (L-660711 sodium salt) 是一种可口服的选择性白三烯 D4受体拮抗剂，在豚鼠和人肺膜的 Ki 分别为0.22 和 2.1 nM。
T22668	Cinalukast	Others	Others
	CysLT1 leukotriene receptor antagonist
T68392	ONO-4310321
	ONO-4310321 is a potent, orally available dual CysLT1 and CysLT2 receptor antagonist.
T11860	LM-1484	Others	Others
	LM-1484 displays a higher affinity for 3H-LTC4 sites and is an antagonist of CysLT1 receptor.
T37016	Iralukast (CGP 45715A)
	Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1.
T69278	FPL-55712
	FPL-55712 is a CysLT1 leukotriene receptor antagonist.
T70330	ONO-2050297
	ONO-2050297 is the first potent dual CysLT1 and CysLT2 antagonist with IC50 values of 0.017 μM (CysLT1) and 0.00087 μM (CysLT2), respectively.
T71273	CAY10788
	CAY10788 is an antagonist of CysLT1 receptor.
T31043	CP-199330 UNII-V4WYK6T8QA,CP 199330,UNII-74573Q728X,CP-199330 sodium
	CP-199330 is a cysteyl LT1 receptor antagonist with no hepatotoxicity and is equivalent to the commercially available CYSLT1 receptor antagonists Zafirlukast and Pranlukas.
T37386	Dihydro Montelukast
	Dihydro montelukast is a potential impurity found in commercial montelukast preparations. Montelukast (sodium salt) is a potent and selective cysteinyl leukotriene 1 (CysLT1) receptor antagonist. Formulations containing montelukast are used for the treatment of asthma as well as for the symptoms associated with allergic rhinitis.
T72145	Montelukast dicyclohexylamine MK0476 dicyclohexylamine
	Montelukast (MK0476) dicyclohexylamine 是一种有效、选择性且具口服活性的半胱氨酸白三烯受体1 (CysLT1) 拮抗剂，用于哮喘和肝损伤预防研究。它在肠缺血-再灌注损伤中展现抗氧化作用，减轻心脏损伤，并降低嗜酸性粒细胞对哮喘气道的浸润。此外，亦被用于COVID-19的研究。
T83926	S-Geranylgeranyl-L-glutathione GGG
	S-Geranylgeranyl-L-glutathione是孤儿G蛋白偶联受体（GPCR）P2RY8的配体。该化合物在100 nM浓度下，选择性地诱导P2RY8而非鞘氨醇-1-磷酸受体2（S1P2）、GPR55、半胱氨酸白三烯受体1（CysLT1 receptor）以及CysLT2 receptor的内吞作用。在10 nM浓度下，S-Geranylgeranyl-L-glutathione抑制了表达P2RY8的WEHI-231 B细胞淋巴瘤细胞和分离的人扁桃体生发中心B细胞由趋化因子（C-X-C motif）配体12（CXCL12）诱导的迁移。
T37980	N-methyl Leukotriene C4 N-methyl Leukotriene C4
	Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukot...
T21864	BAY-u 9773
	BAY-u 9773 是 CysLT 受体(半胱氨酸白三烯受体)的非选择性拮抗剂，对于 CysLT1和 CysLT2的 IC50值大致相同，用于抑制白三烯反应。

化合物

Cat.No: T11388

Synonym: ONO-6950

Target: Others

Cat.No: T7841

Synonym: MK-571钠盐,L660711,L-660711,MK-571

Target: LTR

Cat.No: T3148

Synonym: L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid

Target: Leukotriene Receptor, LTR

Cat.No: T22668

Target: Others

Cat.No: T68392

Cat.No: T11860

Target: Others

Iralukast (CGP 45715A)

Cat.No: T37016

Cat.No: T69278

Cat.No: T70330

Cat.No: T71273

Cat.No: T31043

Synonym: UNII-V4WYK6T8QA,CP 199330,UNII-74573Q728X,CP-199330 sodium

Dihydro Montelukast

Cat.No: T37386

Montelukast dicyclohexylamine

Cat.No: T72145

Synonym: MK0476 dicyclohexylamine

S-Geranylgeranyl-L-glutathione

Cat.No: T83926

Synonym: GGG

N-methyl Leukotriene C4

Cat.No: T37980

Synonym: N-methyl Leukotriene C4

Cat.No: T21864

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03749	CYSLTR1 Protein, Human, Recombinant (His) Cysteinyl leukotriene receptor 1,G-protein coupled ...	Human	E. coli
	Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

重组蛋白

CYSLTR1 Protein, Human, Recombinant (His)

Cat.No: TMPH-03749

Species: Human

Expression System: E. coli

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼